Neuron: June 15, 2022 (Volume 110, Issue 12)

[Advertisement] [Cell press](%2F%2Fwww.cell.com/1/010001816870dcfb-df6ca5ef-6b1c-4ba8-a532-d368ebc33458-000000/_4X6QFCoJG4t3FbvkMZmrfeEVs2S_gr79nr_Adlk-hg=253) [Facebook](%2F%2Ffacebook.com%2Fcellpress/1/010001816870dcfb-df6ca5ef-6b1c-4ba8-a532-d368ebc33458-000000/IfqFTh7Eurwb8y0HgxafGdzCHJqS55ZWNqk3z_er6G8=253) [Twitter](%2F%2Ftwitter.com%2FNeuroCellPress/1/010001816870dcfb-df6ca5ef-6b1c-4ba8-a532-d368ebc33458-000000/BzCfIWk-NCiXWmJ7T3Jp8RgRkiifFn8n2b_3wB3f6Tk=253) [Youtube](%2F%2Fwww.youtube.com%2Fuser%2Fcellvideoabstracts/1/010001816870dcfb-df6ca5ef-6b1c-4ba8-a532-d368ebc33458-000000/_cJaSvB9Qp69JKuDQY0_rIPdwSYcnP827PQpSHANmwk=253) [Weibo](%2F%2Fweibo.com%2FCellPress/1/010001816870dcfb-df6ca5ef-6b1c-4ba8-a532-d368ebc33458-000000/zh3JxnuNJmcTkahbPXoypGpC5_F9HJgXEwAdOyHAbYE=253) [Issue cover](%2F%2Fwww.cell.com%2Fneuron%2Fissue%3Fpii=S0896627321X0013X/1/010001816870dcfb-df6ca5ef-6b1c-4ba8-a532-d368ebc33458-000000/n-y-W69yadtV97ihcQ5KIKLZL5kpq_1WT4ucTFvOzGw=253) [Jun 15, 2022](%2F%2Fwww.cell.com%2Fneuron%2Fissue%3Fpii=S0896627321X0013X/2/010001816870dcfb-df6ca5ef-6b1c-4ba8-a532-d368ebc33458-000000/mfX5ftfY70Sx1sy1SCSe_ACnKzqxShBZ920qFr2n50s=253) Vol. 110, Iss. 12 [Website](%2F%2Fwww.cell.com%2Fneuron%2Fhome%3Fdgcid=raven_jbs_etoc_email/1/010001816870dcfb-df6ca5ef-6b1c-4ba8-a532-d368ebc33458-000000/ftPOOp96_k5iodbkl_jjKZ0oRgNneu6TQZTMR3K2BKg=253) [Table of Contents](%2F%2Fwww.cell.com%2Fneuron%2Fissue%3Fpii=S0896627321X0013X%26dgcid=raven_jbs_etoc_email/1/010001816870dcfb-df6ca5ef-6b1c-4ba8-a532-d368ebc33458-000000/lml-sQWD7-ptKOk-6hVUwnq3ApfCUZUK3w-J7nXPVmk=253) [Online Now](%2F%2Fwww.cell.com%2Fneuron%2Fnewarticles%3Fdgcid=raven_jbs_etoc_email/1/010001816870dcfb-df6ca5ef-6b1c-4ba8-a532-d368ebc33458-000000/cnFOMe-9xg4DQLN1VBK9RonamJUag1kebIJB1vu4CWs=253) [Archive](%2F%2Fwww.cell.com%2Fneuron%2Farchive%3Fdgcid=raven_jbs_etoc_email/1/010001816870dcfb-df6ca5ef-6b1c-4ba8-a532-d368ebc33458-000000/91unQ2hAIyJ8mawez7Jvrdi4tT58ab-khZt1JJypRhk=253) Highlights Announcements --------------------------------------------------------------- [Cell Symposia: Neuro-immune axis](%2F%2Fwww.cell-symposia.com%2Fneuroimmunology-2022%2Fdefault.asp/1/010001816870dcfb-df6ca5ef-6b1c-4ba8-a532-d368ebc33458-000000/GbzYlRB0fqELM-DUcS5UoorH61lR1gYMjCAg9GFKGEw=253) September 11-13, 2022 | Lisbon, Portugal - Keynotes: Yasmine Belkaid & Charles Zuker [Register before July 1, 2022 and save €100](%2F%2Fwww.cell-symposia.com%2Fneuroimmunology-2022%2Fdefault.asp/2/010001816870dcfb-df6ca5ef-6b1c-4ba8-a532-d368ebc33458-000000/QQdkwrWfw6SI5B9oOnvD9A5EzG1GJRZKUR-6kbA3PeM=253) [Cell Press celebrates Pride Month 2022](%2F%2Fcell.com%2Fcp%2Fcollections-pride/1/010001816870dcfb-df6ca5ef-6b1c-4ba8-a532-d368ebc33458-000000/wD5KEmkYzfRVTpIgjGu1RGyvuBsQtNWWdqQtcsRqN7A=253) For Pride, we've created a collection centered around experiences and issues connected to the LGBTQ+ communities in science. [View and share the collection](%2F%2Fcell.com%2Fcp%2Fcollections-pride/2/010001816870dcfb-df6ca5ef-6b1c-4ba8-a532-d368ebc33458-000000/S0-3XpZm3xlNTQDClCmB-XnAs1TzIqUtPgrIzu-lCX0=253) [Join us June 24 in London for LabLinks: Decision-making: From molecular to cognitive neuroscience](%2F%2Finfo.cell.com%2Flablinks-decision-making-2022/1/010001816870dcfb-df6ca5ef-6b1c-4ba8-a532-d368ebc33458-000000/I4FPvnxb-RHyk2TRxUNe8SXqHCt1vByurFJnkrgnhFU=253) This free in-person event will bring together neuroscientists from all disciplines to discuss the latest findings and future challenges in the neuroscience of decision-making. [Register today!](%2F%2Finfo.cell.com%2Flablinks-decision-making-2022/2/010001816870dcfb-df6ca5ef-6b1c-4ba8-a532-d368ebc33458-000000/8Waonltq_82pfHDjjICYQHUc1BA0V57SDUaShL37ErU=253) Featured articles --------------------------------------------------------------- [Programming axonal mitochondrial maintenance and bioenergetics in neurodegeneration and regeneration](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00251-3/1/010001816870dcfb-df6ca5ef-6b1c-4ba8-a532-d368ebc33458-000000/VlafxE2CKpIBL2b7T2_QGW8LPDfdoSsDbbrIIvCbzUg=253) Cheng et al. [Functional coupling of TRPM2 and extrasynaptic NMDARs exacerbates excitotoxicity in ischemic brain injury](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00257-4/1/010001816870dcfb-df6ca5ef-6b1c-4ba8-a532-d368ebc33458-000000/h9mcTMl2y8kjEIp8I4zgPWOXP5_kKlhNGoBgx22q-uI=253) Zong et al. [A single vomeronasal receptor promotes intermale aggression through dedicated hypothalamic neurons](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00410-X/1/010001816870dcfb-df6ca5ef-6b1c-4ba8-a532-d368ebc33458-000000/aV2CizLDYjgzwlC8-gPc0-IwT8ERVp941pQ88vadF7A=253) Itakura et al. [General anesthesia globally synchronizes activity selectively in layer 5 cortical pyramidal neurons](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00303-8/1/010001816870dcfb-df6ca5ef-6b1c-4ba8-a532-d368ebc33458-000000/i3OvgWPxYh9A4aVYO8X5s-bPIYME9Lt_aqfjXXBRte4=253) Bharioke et al. Online now --------------------------------------------------------------- [Sodium-calcium exchanger-3 regulates pain "wind-up": From human psychophysics to spinal mechanisms](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00458-5/1/010001816870dcfb-df6ca5ef-6b1c-4ba8-a532-d368ebc33458-000000/CPNFrPB5OH5Zp5IHdIfFs7WlINLTMeLJp3iwMluNQ38=253) Trendafilova et al. [Medial and orbital frontal cortex in decision-making and flexible behavior](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00463-9/1/010001816870dcfb-df6ca5ef-6b1c-4ba8-a532-d368ebc33458-000000/DaMimbNGEMsQImBUDagejOThEfgFzbZ8PxgzXM63ZF0=253) Klein-Flügge et al. [Dynamic task-belief is an integral part of decision-making](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00451-2/1/010001816870dcfb-df6ca5ef-6b1c-4ba8-a532-d368ebc33458-000000/RPnI-UWj0DszJ3VAGGDT6iZvdmiJPixS-2jNEB6foS4=253) Xue et al. [Single-cell activity and network properties of dorsal raphe nucleus serotonin neurons during emotionally salient behaviors](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00456-1/1/010001816870dcfb-df6ca5ef-6b1c-4ba8-a532-d368ebc33458-000000/FLb0_bYUxXPZGm9Lx2b8eNBRvfariJYZDNoRs8gotQ4=253) Paquelet et al. Table of Contents Previews --------------------------------------------------------------- [Another win for mimetic peptides in stroke: Disruption of TRPM2-NMDAR signaling](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00461-5%3Fdgcid=raven_jbs_etoc_email/1/010001816870dcfb-df6ca5ef-6b1c-4ba8-a532-d368ebc33458-000000/3bQZYPVl-MEfpwRXByXTALKQQPSetzdtM7C13WYmKv0=253) Andrew K.J. Boyce, Roger J. Thompson Glutamate excitotoxicity during ischemia triggers an intracellular signaling avalanche leading to cell death, yet blocking NMDA receptors directly in human stroke trials failed. In this issue of Neuron, Zong et al. (2022) disrupt downstream NMDAR-TRPM2 coupling to improve stroke outcomes, supporting intracellular NMDAR signaling as an alternate therapeutic target. [Interneuron switching on and off across memory rhythms](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00460-3%3Fdgcid=raven_jbs_etoc_email/1/010001816870dcfb-df6ca5ef-6b1c-4ba8-a532-d368ebc33458-000000/JXyNKAmLvEBO45rC1IycAKkPiTdhQa-91Lx113p-ees=253) Alexandra Tzilivaki, Nikolaus Maier, Dietmar Schmitz In this issue of Neuron, Szabo et al. uncover a unique subtype of interneurons that is highly active during ripples but largely silent during theta oscillations. The study provides exciting new insights into the regulation and propagation of ripples in CA1 and beyond. [What’s familiarity got to do with it? Neural mechanisms of observational fear in siblings and strangers](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00454-8%3Fdgcid=raven_jbs_etoc_email/1/010001816870dcfb-df6ca5ef-6b1c-4ba8-a532-d368ebc33458-000000/B3xHz3Wv1sZlWF3IlHCPXr1d0Gp6gVFvv523GvaUg5M=253) Inbal Ben-Ami Bartal Social modulation of pain sensitivity is considered part of the empathic response. In this issue of Neuron, Zhang at al. (2022) uncover the neurobiological basis of observational pain in mice. They report increased synaptic transmission from the insular cortex to the basolateral amygdala and explore genes mediating this effect. [Fatherhood is life changing: Uncovering structural and functional changes in the dad brain](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00500-1%3Fdgcid=raven_jbs_etoc_email/1/010001816870dcfb-df6ca5ef-6b1c-4ba8-a532-d368ebc33458-000000/rw7LZ0eUGYwY4amB3N66uFvPbyzQxRmGkDI5LUw1Y9g=253) Richard G. Dickson, Matthew W. Jacobs, Euiseok J. Kim What are the cellular-level structural and functional changes underlying newly adaptive behaviors in the mammalian brain? In this issue of Neuron, Inada et al. (2022) identify the brain-wide connectivity and synaptic plasticity changes of hypothalamic oxytocin+ neurons in male mice contributing to their parental behaviors. [General anesthesia and the cortical stranglehold on consciousness](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00455-X%3Fdgcid=raven_jbs_etoc_email/1/010001816870dcfb-df6ca5ef-6b1c-4ba8-a532-d368ebc33458-000000/TGB4VdpobmktS-t2rqzoHcC1PS0ABrcrHn1AvYcXWL8=253) Dinesh Pal, George A. Mashour In this issue of Neuron, Bharioke et al. (2022) demonstrate that diverse general anesthetic regimens all reversibly and selectively synchronize spontaneous activity of pyramidal neurons in layer 5 of mouse cortex. We discuss the implications of these findings for the mechanism of consciousness and anesthetic-induced unconsciousness. Meeting report --------------------------------------------------------------- [Emerging principles of spacetime in brains: Meeting report on spatial neurodynamics](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00459-7%3Fdgcid=raven_jbs_etoc_email/1/010001816870dcfb-df6ca5ef-6b1c-4ba8-a532-d368ebc33458-000000/IAlz50q9ldKE0cXmtPapGDVKIJItffnvqvSf7HFpmhc=253) Sonja Grün, Jennifer Li, Bruce McNaughton, Carl Petersen, David McCormick, Drew Robson, György Buzsáki, Kenneth Harris, Terrence Sejnowski, Thomas Mrsic-Flogel, Henrik Lindén, Per E. Roland How do neurons and networks of neurons interact spatially? Here, Grün et al. overview recent discoveries revealing how spatial dynamics of spiking and postsynaptic activity efficiently expose and explain fundamental brain and brainstem mechanisms behind detection, perception, learning, and behavior. Review --------------------------------------------------------------- [Programming axonal mitochondrial maintenance and bioenergetics in neurodegeneration and regeneration](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00251-3%3Fdgcid=raven_jbs_etoc_email/1/010001816870dcfb-df6ca5ef-6b1c-4ba8-a532-d368ebc33458-000000/YOGHLxNpcqoaoNu4TlMSfbLKzIHhOEc7Raz5pY6JJNM=253) Xiu-Tang Cheng, Ning Huang, Zu-Hang Sheng Cheng, Huang, and Sheng review recent advances in how neurons maintain a healthy pool of axonal mitochondria to power neuronal function and how energy deficits contribute to neurodegeneration and regeneration failure and provide perspectives on the strategies targeting axonal bioenergetic restoration. Report --------------------------------------------------------------- [Deficits in decision-making induced by parietal cortex inactivation are compensated at two timescales](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00258-6%3Fdgcid=raven_jbs_etoc_email/1/010001816870dcfb-df6ca5ef-6b1c-4ba8-a532-d368ebc33458-000000/Sej5WlH4WaqBbBx68qguxiOogbHKGt5nw4wfbhZ0g7A=253) Danique Jeurissen, S. Shushruth, Yasmine El-Shamayleh, Gregory D. Horwitz, Michael N. Shadlen Open Access Jeurissen et al. inactivate a parietal cortical area thought to play a role in perceptual decision-making. Silencing causes monkeys to bias decisions, consistent with partial hemineglect. The bias dissipates over 30 min and over subsequent experiments. The results expose a capacity of the brain to compensate for focal insult. Articles --------------------------------------------------------------- [Regional Aβ-tau interactions promote onset and acceleration of Alzheimer’s disease tau spreading](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00305-1%3Fdgcid=raven_jbs_etoc_email/1/010001816870dcfb-df6ca5ef-6b1c-4ba8-a532-d368ebc33458-000000/Td1nowO0nH6k948G9IsHUKArTgo4iGEFxvhZAaOARnQ=253) Wha Jin Lee, Jesse A. Brown, Hye Ryun Kim, Renaud La Joie, Hanna Cho, Chul Hyoung Lyoo, Gil D. Rabinovici, Joon-Kyung Seong, William W. Seeley Lee et al. show that the natural history of AD traverses a critical period that begins once Aβ emerges within entorhinal cortex (EC)-connected regions, continues as tau spreads from the EC into connected mesial temporal and limbic regions, and may end once Aβ and tau interact within the inferior temporal gyrus propagation hubs, whose connections are well suited to facilitate widespread neocortical tau propagation. [Functional coupling of TRPM2 and extrasynaptic NMDARs exacerbates excitotoxicity in ischemic brain injury](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00257-4%3Fdgcid=raven_jbs_etoc_email/1/010001816870dcfb-df6ca5ef-6b1c-4ba8-a532-d368ebc33458-000000/4yLwz3rzumWdKxF-5ntVQbp3IyPQw2uTnfUW_h_oQ0Y=253) Pengyu Zong, Jianlin Feng, Zhichao Yue, Yunfeng Li, Gongxiong Wu, Baonan Sun, Yanlin He, Barbara Miller, Albert S. Yu, Zhongping Su, Jia Xie, Yasuo Mori, Bing Hao, Lixia Yue Zong et al. discover an unexpected association between the oxidative stress-sensitive ion channel TRPM2 and the extrasynaptic NMDA receptor (NMDAR) in the neurons, which enhances excitotoxicity during ischemic brain injury. Neuron-specific knockout of TRPM2 or uncoupling of the TRPM2-NMDAR association using an interfering peptide protects mice against ischemic stroke. [Ripple-selective GABAergic projection cells in the hippocampus](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00310-5%3Fdgcid=raven_jbs_etoc_email/1/010001816870dcfb-df6ca5ef-6b1c-4ba8-a532-d368ebc33458-000000/-sE4-URSST1QygTuhCKOczRwVRrvAXvJcRquoaYURaI=253) Gergely G. Szabo, Jordan S. Farrell, Barna Dudok, Wen-Hsien Hou, Anna L. Ortiz, Csaba Varga, Prannath Moolchand, Cafer Ikbal Gulsever, Tilo Gschwind, Jordane Dimidschstein, Marco Capogna, Ivan Soltesz Open Access Szabo et al. identify a subset of hippocampal GABAergic cells with long-range projections and unique activity dynamics. Theta-OFF/ripple-ON (TORO) cells are virtually silent during locomotion and REM sleep theta but fire vigorously during sharp-wave ripples. TORO cells receive CA3 glutamatergic, septal GABAergic, and inhibitory cholinergic inputs and target interneurons. [Signatures of rapid plasticity in hippocampal CA1 representations during novel experiences](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00262-8%3Fdgcid=raven_jbs_etoc_email/1/010001816870dcfb-df6ca5ef-6b1c-4ba8-a532-d368ebc33458-000000/QqjaynnvJfPe0C14wBzwRvH8IHZp-P4dP3FYsx4Hpcw=253) James B. Priestley, John C. Bowler, Sebi V. Rolotti, Stefano Fusi, Attila Losonczy By combining virtual reality and two-photon calcium imaging, Priestley et. al. find pervasive signatures of rapid neural plasticity mechanisms in the mouse hippocampus during new experiences. Their study highlights a strong regulation of neural feature tuning in CA1 by novelty, which could contribute to quickly encoding new memories. [Glutamatergic synapses from the insular cortex to the basolateral amygdala encode observational pain](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00266-5%3Fdgcid=raven_jbs_etoc_email/1/010001816870dcfb-df6ca5ef-6b1c-4ba8-a532-d368ebc33458-000000/togKmTlMPqG4qmQocxLYRLOuhVt6lheuC2xc5FoiBjs=253) Ming-Ming Zhang, An-Qi Geng, Kun Chen, Jian Wang, Pan Wang, Xin-Tong Qiu, Jun-Xiang Gu, Hong-Wei Fan, Da-Yu Zhu, Shan-Ming Yang, Qi-Yu Chen, Zhao-Xiang Zhou, Bo-Yuan Fan, Yang Bai, Ke-Ke Xing, Jia-Ming Feng, Jun-Da Wang, Yan Chen, Ya-Cheng Lu, Ying Liang, Peng Cao, Bong-Kiun Kaang, Min Zhuo, Yun-Qing Li, Tao Chen Zhang et al. show that sibling but not stranger observer mice exhibit observational pain, which requires glutamate transmission from the insular cortex to the basolateral amygdala and is regulated by synaptotagmin-2 and RIM3. [Plasticity of neural connections underlying oxytocin-mediated parental behaviors of male mice](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00304-X%3Fdgcid=raven_jbs_etoc_email/1/010001816870dcfb-df6ca5ef-6b1c-4ba8-a532-d368ebc33458-000000/hwgyLmOuvwvDQEEVmD_ltrvzov1j1891EeafURfJVrs=253) Kengo Inada, Mitsue Hagihara, Kazuko Tsujimoto, Takaya Abe, Ayumu Konno, Hirokazu Hirai, Hiroshi Kiyonari, Kazunari Miyamichi Inada et al. discover that OT is indispensable for the expression of parental behaviors in male mice. Both connectivity and synaptic transmission from excitatory LHA neurons to PVH OT neurons are enhanced in the fathers. They further show that the enhancement contributes to the suppression of pup-directed aggression. [General anesthesia globally synchronizes activity selectively in layer 5 cortical pyramidal neurons](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00303-8%3Fdgcid=raven_jbs_etoc_email/1/010001816870dcfb-df6ca5ef-6b1c-4ba8-a532-d368ebc33458-000000/Iu9-nX9Uy5dUFnwkWjgkcwB72pP8HG6k_Hw9d2mQtkw=253) Arjun Bharioke, Martin Munz, Alexandra Brignall, Georg Kosche, Max Ferdinand Eizinger, Nicole Ledergerber, Daniel Hillier, Brigitte Gross-Scherf, Karl-Klaus Conzelmann, Emilie Macé, Botond Roska Open Access Bharioke, Munz et al. discovered that different general anesthetics consistently synchronize spontaneous activity of mouse layer 5 pyramidal neurons, but of no other cortical cell type, in vivo. Strikingly, changes in synchrony across layer 5 pyramidal neurons, during transitions to and from anesthesia, coincide with loss and recovery of consciousness. [Update Your Profile](%2F%2Fwww.cell.com%2Faction%2FshowPreferences%3FmenuTab=Alerts%26code=cell-site/1/010001816870dcfb-df6ca5ef-6b1c-4ba8-a532-d368ebc33458-000000/jkdCvtfztTOcrCQccmGYkNpXQoalpGGqsgzxeduqntE=253) [Terms and Conditions](%2F%2Fwww.elsevier.com%2Flegal%2Felsevier-website-terms-and-conditions/1/010001816870dcfb-df6ca5ef-6b1c-4ba8-a532-d368ebc33458-000000/_eUey8ipnBtvx4bQYh1Ovy_kcIyqf2imW4ezfNMWWb0=253) [Privacy Policy](%2F%2Fwww.elsevier.com%2Flegal%2Fprivacy-policy/1/010001816870dcfb-df6ca5ef-6b1c-4ba8-a532-d368ebc33458-000000/NrwigyoX9MOKA-UJAsUQwNbrjbkRZqysJs7a_2lftsI=253) [Follow this link to unsubscribe.](%2F%2Fwww.cell.com%2Falerts%2Funsubscribe%3FsubscriptionID=c1bedb93-d933-486c-b094-8eaf812d893b%26hash=eeca2f294f987df4d4ae56abbd699bf6e686193b/1/010001816870dcfb-df6ca5ef-6b1c-4ba8-a532-d368ebc33458-000000/jDBT_CN6bpy6nlkQQMh7EN7zl3iDcqdIXy9blMvELe8=253) This email has been sent from Cell Press, a division of Elsevier Inc., 50 Hampshire Street, 5th Floor, Cambridge, MA 02139, USA. You are receiving this email because you signed up for email alerts for new issues of this journal. For all inquiries, problems or suggestions regarding this service, please contact [our support group.](%2F%2Fservice.elsevier.com%2Fapp%2Foverview%2Fcell-press%2F/1/010001816870dcfb-df6ca5ef-6b1c-4ba8-a532-d368ebc33458-000000/MmChnOS5D80xkl_40MHchNrUe3TG6TdjrIrqKOWxPUE=253) Copyright © 2022 Elsevier Inc. All rights reserved. Subscription ID: c1bedb93-d933-486c-b094-8eaf812d893b Webuser ID: a55d53f7ab892786bd7dece67e5041dc06f264ea Results Event ID: fcbcea53-ed87-4c1e-9f69-0dcd4ed57e5f