Neuron: May 18, 2022 (Volume 110, Issue 10)

[Advertisement] [Cell press](%2F%2Fwww.cell.com/1/01000180d7ddc1e1-dddd5de8-86a7-4fc7-9166-01325ad39fcf-000000/xI3aS712iNkN_ppQgqU7WP8zLP_v7MdcEPUisKKRjCU=249) [Facebook](%2F%2Ffacebook.com%2Fcellpress/1/01000180d7ddc1e1-dddd5de8-86a7-4fc7-9166-01325ad39fcf-000000/QEoqFCzX9Nrpb8LiDcSQ9DEiHotnuxDp_f9UJSpHZpE=249) [Twitter](%2F%2Ftwitter.com%2FNeuroCellPress/1/01000180d7ddc1e1-dddd5de8-86a7-4fc7-9166-01325ad39fcf-000000/rQk6ZcKufN_fcfX0cTclTa7NAn3kFf3Z-NnI6sxFLmQ=249) [Youtube](%2F%2Fwww.youtube.com%2Fuser%2Fcellvideoabstracts/1/01000180d7ddc1e1-dddd5de8-86a7-4fc7-9166-01325ad39fcf-000000/zEJ22XghhzH0QWEgAY7IVlqnmbCOwBCBbjk3ZYClpQg=249) [Weibo](%2F%2Fweibo.com%2FCellPress/1/01000180d7ddc1e1-dddd5de8-86a7-4fc7-9166-01325ad39fcf-000000/-lRHaFcpaLGy7qvWc6Gsc7-kJG0JtHRmwpoGgJUwp30=249) [Issue cover](%2F%2Fwww.cell.com%2Fneuron%2Fissue%3Fpii=S0896627321X00116/1/01000180d7ddc1e1-dddd5de8-86a7-4fc7-9166-01325ad39fcf-000000/QSHtlzHJhV6p0e8FkHjMuTTfh0cy6o88Ry872boLHYQ=249) [May 18, 2022](%2F%2Fwww.cell.com%2Fneuron%2Fissue%3Fpii=S0896627321X00116/2/01000180d7ddc1e1-dddd5de8-86a7-4fc7-9166-01325ad39fcf-000000/Dj38Q17l4xnTkJpYTY1W2qrSxVbtdEaP9J1cMILsi6A=249) Vol. 110, Iss. 10 [Website](%2F%2Fwww.cell.com%2Fneuron%2Fhome%3Fdgcid=raven_jbs_etoc_email/1/01000180d7ddc1e1-dddd5de8-86a7-4fc7-9166-01325ad39fcf-000000/W7umhzWMxcba6s2-1F8KEe9AiFeNv2KRRed_3SowT4E=249) [Table of Contents](%2F%2Fwww.cell.com%2Fneuron%2Fissue%3Fpii=S0896627321X00116%26dgcid=raven_jbs_etoc_email/1/01000180d7ddc1e1-dddd5de8-86a7-4fc7-9166-01325ad39fcf-000000/fjfJxRwmzrN1i_Tq6Cgu-bfoojyDwc8o0EvRGCqHibw=249) [Online Now](%2F%2Fwww.cell.com%2Fneuron%2Fnewarticles%3Fdgcid=raven_jbs_etoc_email/1/01000180d7ddc1e1-dddd5de8-86a7-4fc7-9166-01325ad39fcf-000000/OnQ_K5OT6NxuG3jXY_C22preQLrBaARQkRwnx3feu9I=249) [Archive](%2F%2Fwww.cell.com%2Fneuron%2Farchive%3Fdgcid=raven_jbs_etoc_email/1/01000180d7ddc1e1-dddd5de8-86a7-4fc7-9166-01325ad39fcf-000000/otnj2Nr24ljgp8r9kUT67BsElovuk-NJYWosiScsaBY=249) Highlights Announcements --------------------------------------------------------------- [Explore our SpatioTemporal Omics Consortium collection!](%2F%2Fwww.cell.com%2Fconsortium%2Fspatiotemporal-omics/1/01000180d7ddc1e1-dddd5de8-86a7-4fc7-9166-01325ad39fcf-000000/VQjh9atSGgDHriAQm7h4uDUTIXNu4laCrwg8kY9It50=249) A collection of papers aiming to help researchers around the globe understand the molecular dynamics of fundamental biological processes across eukaryotic kingdoms of life over time and space. [View the collection](%2F%2Fwww.cell.com%2Fconsortium%2Fspatiotemporal-omics/2/01000180d7ddc1e1-dddd5de8-86a7-4fc7-9166-01325ad39fcf-000000/cUNBJRKmBfNFnNeRfQM8uTMMxqQ0U-WzHKmeHwBalq0=249) [Webinar: The fight against COVID 19: what comes next?](%2F%2Fwww.workcast.com%2Fregister%3Fcpak=4542814521687131%2520%26referrer=etoc/1/01000180d7ddc1e1-dddd5de8-86a7-4fc7-9166-01325ad39fcf-000000/U25NzWeIvaHJUeDb78hbqNKD2RdpMwcV6m2tF3ws-rA=249) June 8, 2022, 12pm ET | Speakers: Arun Kumar (Coalition for Epidemic Preparedness Innovation, Oslo), Dirk Grimm (University of Heidelberg) & John Chandy (Indiana University). [Register for free](%2F%2Fwww.workcast.com%2Fregister%3Fcpak=4542814521687131%2520%26referrer=etoc/2/01000180d7ddc1e1-dddd5de8-86a7-4fc7-9166-01325ad39fcf-000000/yoxb49F1u72tnMmtU85iJeBlPzUCn6tYdUoDnZT4wDY=249) [Cell Symposia: Neuro-immune axis](%2F%2Fwww.cell-symposia.com%2Fneuroimmunology-2022%2Fdefault.asp/1/01000180d7ddc1e1-dddd5de8-86a7-4fc7-9166-01325ad39fcf-000000/YmkuiQK6K29W_25T5G6qtHKy5xYGROpLtoJIfSDSz7s=249 ) September 11–13, 2022 | Lisbon, Portugal – Keynotes: Yasmine Belkaid & Charles Zuker. [Good news, abstract submission deadline extended until May 27, 2022 – submit your abstract here](%2F%2Fwww.cell-symposia.com%2Fneuroimmunology-2022%2Fdefault.asp/2/01000180d7ddc1e1-dddd5de8-86a7-4fc7-9166-01325ad39fcf-000000/mhzOXxggyHOGODUDFMGmN8PawCDlowzbr9Vc-OJjgI8=249 ) Featured articles --------------------------------------------------------------- [Logistic analysis of choice data: A primer](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00203-3/1/01000180d7ddc1e1-dddd5de8-86a7-4fc7-9166-01325ad39fcf-000000/b2S5jtpYAS1O1F8hii4mabV-Jc2MlwAUrQkbIZBU-Ho=249) Padoa-Schioppa [Overcoming addiction stigma: Epigenetic contributions to substance use disorders and opportunities for intervention](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00254-9/1/01000180d7ddc1e1-dddd5de8-86a7-4fc7-9166-01325ad39fcf-000000/6I_U7ipa05JL3rbI1WD0A_rOrqyf3DuQgK7VO6OMn1w=249) Szutorisz et al. [Pericyte-to-endothelial cell signaling via vitronectin-integrin regulates blood-CNS barrier](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00184-2/1/01000180d7ddc1e1-dddd5de8-86a7-4fc7-9166-01325ad39fcf-000000/QeLIGhtgSVqCVYp3bRY2Xu5oznOS-aZCPaMEIkCHxX4=249) Ayloo et al. Online now --------------------------------------------------------------- [Global and subtype-specific modulation of cortical inhibitory neurons regulated by acetylcholine during motor learning](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00408-1/1/01000180d7ddc1e1-dddd5de8-86a7-4fc7-9166-01325ad39fcf-000000/L7WGbTgM5_LjHSOVn1JWstvTAL2x7dJIODaKGH7mbM8=249) Ren et al. [Dysregulation of organelle membrane contact sites in neurological diseases](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00365-8/1/01000180d7ddc1e1-dddd5de8-86a7-4fc7-9166-01325ad39fcf-000000/nehglGH3wEJikOtbd6NEfBYcQP03RHgLggwy46SFLO0=249) Kim et al. [Distinct neural codes in primate hippocampus and lateral prefrontal cortex during associative learning in virtual environments](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00361-0/1/01000180d7ddc1e1-dddd5de8-86a7-4fc7-9166-01325ad39fcf-000000/K2tKsFG9enJMeFr_4dt8NqRXndTX0eoKgqrPeIa3Ttg=249) Corrigan et al. [A novel spinal neuron connection for heat sensation](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00366-X/1/01000180d7ddc1e1-dddd5de8-86a7-4fc7-9166-01325ad39fcf-000000/H8GeVZZ6dXkVOx7837OjyQP_lLRRogJbcRVcM_Co10Q=249) Wang et al. Table of Contents Previews --------------------------------------------------------------- [The (ultra)sound of neurons firing](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00402-0%3Fdgcid=raven_jbs_etoc_email/1/01000180d7ddc1e1-dddd5de8-86a7-4fc7-9166-01325ad39fcf-000000/83YOr-YcMNBzevJTivKSpSrFGBehG3yCEgcrt6NWQkE=249) Serge Charpak Functional ultrasound (fUS) is an emerging technique that measures blood flow to report brain activity. In this issue of Neuron, Nunez-Elizalde et al. (2022) use simultaneous electrophysiological and fUS measurements to quantify the relationship between firing and fUS signals in awake mice. [Matrix proteins plug a hole: How pericytes suppress blood brain barrier transcytosis](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00350-6%3Fdgcid=raven_jbs_etoc_email/1/01000180d7ddc1e1-dddd5de8-86a7-4fc7-9166-01325ad39fcf-000000/siaJ3XYTnHqHyJ4TSZn8CVdUk9UeO2SPP6OR5DwGcQc=249) Troy N. Trevino, Sarah E. Lutz How is the brain so efficient at excluding proteins, drugs, and immune cells from the blood? In this issue of Neuron, Ayloo et al. (2022) find that an extracellular matrix protein secreted by CNS pericytes shuts down endocytic transport in blood brain barrier endothelial cells. [Why you always in a mood? Pumpin’ polyP, actin’ brand new](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00311-7%3Fdgcid=raven_jbs_etoc_email/1/01000180d7ddc1e1-dddd5de8-86a7-4fc7-9166-01325ad39fcf-000000/99ZD3YpDG8Ys0gZBKSGIFh1h7T9l62KZ6Wcdk2gOtRQ=249) Kevin A. Guttenplan, Aaron D. Gitler What causes neurons to die in neurodegenerative disease? In this issue of Neuron, Arredondo et al., 2022 report an unexpected culprit that may drive neuronal death in amyotrophic lateral sclerosis—an evolutionarily ancient energy-storage polymer called polyphosphate (polyP). [O-LM interneurons: Gatekeepers of pyramidal neuron activity in the hippocampus](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00367-1%3Fdgcid=raven_jbs_etoc_email/1/01000180d7ddc1e1-dddd5de8-86a7-4fc7-9166-01325ad39fcf-000000/6BiH5aVXB8oxfI5cKGODFkTdyyokZ_hbHP_NW8ldzd8=249) Stefanie Poll, Martin Fuhrmann A balanced and fine-tuned ratio of neuronal excitation and inhibition is a prerequisite for information processing. In this issue of Neuron, He et al. (2022) reveal a causal link between reduced input to local somatostatin-expressing, MeCP2-negative O-LM interneurons in CA1 and long-term memory impairment in a mouse model of Rett syndrome. [Harmonics of the social brain: How diverse brain regions coordinate appetitive social behavior](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00404-4%3Fdgcid=raven_jbs_etoc_email/1/01000180d7ddc1e1-dddd5de8-86a7-4fc7-9166-01325ad39fcf-000000/iLASlM-kFbCF76B8d1pmh7p2iu1Aek__8BZCojY7gbE=249) Stoyo Karamihalev, Nadine Gogolla Socioemotional behaviors rely on the integration of information across multiple systems in the brain. In this issue of Neuron, Mague et al. (2022) characterize a multi-regional functional network that coordinates positively valenced social interactions in mice. NeuroView --------------------------------------------------------------- [Overcoming addiction stigma: Epigenetic contributions to substance use disorders and opportunities for intervention](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00254-9%3Fdgcid=raven_jbs_etoc_email/1/01000180d7ddc1e1-dddd5de8-86a7-4fc7-9166-01325ad39fcf-000000/w6Vy-XuZf4PW0YVRKp6uBPFk_91bJKHWMXXX4PEVJEA=249) Henrietta Szutorisz, Yasmin L. Hurd Substance use disorders (SUDs) are frequently stigmatized by society. However, overcoming stigmas to effectively treat SUDs requires acknowledging the developmental path of neural vulnerability. These vulnerabilities begin long before adulthood, providing opportunities to change the trajectory before the disorder becomes entrenched. This article raises attention to reversible epigenetic underpinnings of this vulnerability. Primer --------------------------------------------------------------- [Logistic analysis of choice data: A primer](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00203-3%3Fdgcid=raven_jbs_etoc_email/1/01000180d7ddc1e1-dddd5de8-86a7-4fc7-9166-01325ad39fcf-000000/fnzdXk8NMfnlIwFYm8ZebrTb4SzQqHRk53XsPoqvON8=249) Camillo Padoa-Schioppa Logistic regressions are the primary method to analyze choice behavior in decision neuroscience studies. In this primer, Padoa-Schioppa describes how logistic analysis can quantify a variety of behavioral traits. He also discusses the assumptions and interpretations of different logistic models. Report --------------------------------------------------------------- [Neural correlates of blood flow measured by ultrasound](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00177-5%3Fdgcid=raven_jbs_etoc_email/1/01000180d7ddc1e1-dddd5de8-86a7-4fc7-9166-01325ad39fcf-000000/QPnruY5yH_LlaadoNzx1ZLomCQkzbg3FY5AJd35zUuc=249) Anwar O. Nunez-Elizalde, Michael Krumin, Charu Bai Reddy, Gabriel Montaldo, Alan Urban, Kenneth D. Harris, Matteo Carandini Open Access Nunez-Elizalde et al. simultaneously measured neural activity with electrodes and blood flow with functional ultrasound imaging (fUSI) in awake mice. Their results establish that blood flow bears a simple and accurate relationship to local neuronal firing at frequencies <0.3 Hz and validate fUSI as a tool to infer neural activity. Articles --------------------------------------------------------------- [Pericyte-to-endothelial cell signaling via vitronectin-integrin regulates blood-CNS barrier](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00184-2%3Fdgcid=raven_jbs_etoc_email/1/01000180d7ddc1e1-dddd5de8-86a7-4fc7-9166-01325ad39fcf-000000/l9L0p_VthdOM4bpGEy4vKJnGvFWH_Gggp8-OdO9YkzU=249) Swathi Ayloo, Christopher Gallego Lazo, Shenghuan Sun, Wei Zhang, Bianxiao Cui, Chenghua Gu Open Access Ayloo et al. reveal a mechanism of how blood-CNS barriers are actively maintained by the CNS microenvironment. They discovered that a ligand-receptor signaling between pericyte-secreted vitronectin and its endothelial cell receptor integrin α5 is critical to suppress transcytosis to ensure barrier integrity in mice. [Excessive release of inorganic polyphosphate by ALS/FTD astrocytes causes non-cell-autonomous toxicity to motoneurons](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00148-9%3Fdgcid=raven_jbs_etoc_email/1/01000180d7ddc1e1-dddd5de8-86a7-4fc7-9166-01325ad39fcf-000000/s7DxaSob4zjcHHuPniNxLYo9rZEfbENd-eA-7CvHgn0=249) Cristian Arredondo, Carolina Cefaliello, Agnieszka Dyrda, Nur Jury, Pablo Martinez, Iván Díaz, Armando Amaro, Helene Tran, Danna Morales, Maria Pertusa, Lorelei Stoica, Elsa Fritz, Daniela Corvalán, Sebastián Abarzúa, Maxs Méndez-Ruette, Paola Fernández, Fabiola Rojas, Meenakshi Sundaram Kumar, Rodrigo Aguilar, Sandra Almeida, Alexandra Weiss, Fernando J. Bustos, Fernando González-Nilo, Carolina Otero, Maria Florencia Tevy, Daryl A. Bosco, Juan C. Sáez, Thilo Kähne, Fen-Biao Gao, James D. Berry, Katharine Nicholson, Miguel Sena-Esteves, Rodolfo Madrid, Diego Varela, Martin Montecino, Robert H. Brown, Brigitte van Zundert Arredondo et al. demonstrate that inorganic polyphosphate (polyP) levels are increased in human and mouse ALS/FTD astrocytes in culture and in tissue as well as in astrocyte-conditioned media (ACM) and cerebrospinal fluid. Targeting polyP in ALS/FTD astrocytes or in derived ACM prevents motoneuron (MN) death. These findings reveal that polyP released by ALS/FTD astrocytes is a critical factor in non-cell-autonomous MN degeneration and a potential therapeutic target for ALS/FTD. [Loss of mouse Stmn2 function causes motor neuropathy](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00176-3%3Fdgcid=raven_jbs_etoc_email/1/01000180d7ddc1e1-dddd5de8-86a7-4fc7-9166-01325ad39fcf-000000/tRjos5qU3J2KublxSGOILRmb7ZjIa2SYomX5D-alMeg=249) Irune Guerra San Juan, Leslie A. Nash, Kevin S. Smith, Marcel F. Leyton-Jaimes, Menglu Qian, Joseph R. Klim, Francesco Limone, Alexander B. Dorr, Alexander Couto, Greta Pintacuda, Brian J. Joseph, D. Eric Whisenant, Caroline Noble, Veronika Melnik, Deirdre Potter, Amie Holmes, Aaron Burberry, Matthijs Verhage, Kevin Eggan The TDP43-regulated gene STMN2 provides a potential connection between TDP43 dysfunction and motor neuropathy as observed in ALS. Guerra San Juan, Nash, et al. demonstrate that mouse Stmn2 is essential for maintaining normal motor function in vivo; its deficiency results in neuromuscular junction denervation, muscle atrophy, and impaired motor behavior. [A weakened recurrent circuit in the hippocampus of Rett syndrome mice disrupts long-term memory representations](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00179-9%3Fdgcid=raven_jbs_etoc_email/1/01000180d7ddc1e1-dddd5de8-86a7-4fc7-9166-01325ad39fcf-000000/Lrlb6wycIfWVfZ2UMpEnV0zbRi29rjDnQ9834k1wxgM=249) Lingjie He, Matthew S. Caudill, Junzhan Jing, Wei Wang, Yaling Sun, Jianrong Tang, Xiaolong Jiang, Huda Y. Zoghbi He et al. describe behavioral and CA1 activity dysfunctions during the long-term recall of a contextual memory in a Rett syndrome mouse model featuring heterozygous Mecp2 expression. The altered behavior and activity correlate with poor recruitment of inhibition from MeCP2-negative OLM cells. Enhancing this inhibition restores long-term memory recall. [A functionally ordered visual feature map in the Drosophila brain](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00178-7%3Fdgcid=raven_jbs_etoc_email/1/01000180d7ddc1e1-dddd5de8-86a7-4fc7-9166-01325ad39fcf-000000/DYYnEY8ZD6Bx37Ue-4GSAy1bDLjb1iZDwlYJpuupbkw=249) Nathan C. Klapoetke, Aljoscha Nern, Edward M. Rogers, Gerald M. Rubin, Michael B. Reiser, Gwyneth M. Card Open Access By combining calcium imaging and synaptic connectivity analysis, Klapoetke et al. reveal that optic glomeruli in the fly central brain form a topographic visual map, with glomeruli anatomically ordered by visual feature selectivity. Downstream circuits appear to exploit this map by integrating primarily from nearby glomeruli encoding similar features. [A visual circuit related to the periaqueductal gray area for the antinociceptive effects of bright light treatment](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00147-7%3Fdgcid=raven_jbs_etoc_email/1/01000180d7ddc1e1-dddd5de8-86a7-4fc7-9166-01325ad39fcf-000000/4Dli-zy30dnnnq2v9ZqdruDu4miqkErNmGm1XaexFvs=249) Zhengfang Hu, Yiman Mu, Lu Huang, Yuqing Hu, Zhiqing Chen, Yan Yang, Xiaodan Huang, Yunwei Fu, Yue Xi, Song Lin, Qian Tao, Fuqiang Xu, Kwok-Fai So, Chaoran Ren Hu et al. identified a visual circuit related to the l/vlPAG that regulates mouse nocifensive behaviors. They demonstrate that the retina-vLGN/IGL-l/vlPAG pathway mediates the antinociceptive effects of bright light treatment. [Brain-wide electrical dynamics encode individual appetitive social behavior](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00181-7%3Fdgcid=raven_jbs_etoc_email/1/01000180d7ddc1e1-dddd5de8-86a7-4fc7-9166-01325ad39fcf-000000/z_fhHDTnJPBxfsLfVTKMdfkbzxXTTbCygxnnpuHJoEw=249) Stephen D. Mague, Austin Talbot, Cameron Blount, Kathryn K. Walder-Christensen, Lara J. Duffney, Elise Adamson, Alexandra L. Bey, Nkemdilim Ndubuizu, Gwenaëlle E. Thomas, Dalton N. Hughes, Yael Grossman, Rainbo Hultman, Saurabh Sinha, Alexandra M. Fink, Neil M. Gallagher, Rachel L. Fisher, Yong-Hui Jiang, David E. Carlson, Kafui Dzirasa Mague, Talbot et al. applied machine learning to discover a brain-wide electrical network that encodes individual rewarding social experiences in mice. Stimulation of circuits within the network increases social behavior. Strikingly, the network fails to encode individual social experience in a genetic mouse model of autism. [Update Your Profile](%2F%2Fwww.cell.com%2Faction%2FshowPreferences%3FmenuTab=Alerts%26code=cell-site/1/01000180d7ddc1e1-dddd5de8-86a7-4fc7-9166-01325ad39fcf-000000/cH3ueqk2LGFNuBpJMAWtA0JrrEXEGpiCaYWGbQog1Sk=249) [Terms and Conditions](%2F%2Fwww.elsevier.com%2Flegal%2Felsevier-website-terms-and-conditions/1/01000180d7ddc1e1-dddd5de8-86a7-4fc7-9166-01325ad39fcf-000000/FCaFlBHITj-lYYZx_DIUzDy-ykQNCAozviAFc3va2Gs=249) [Privacy Policy](%2F%2Fwww.elsevier.com%2Flegal%2Fprivacy-policy/1/01000180d7ddc1e1-dddd5de8-86a7-4fc7-9166-01325ad39fcf-000000/9Uy3f5OFtPSsgr-iT6ZbX0JZAmW3fz2y-4rl_esCZqM=249) [Follow this link to unsubscribe.](%2F%2Fwww.cell.com%2Falerts%2Funsubscribe%3FsubscriptionID=c1bedb93-d933-486c-b094-8eaf812d893b%26hash=eeca2f294f987df4d4ae56abbd699bf6e686193b/1/01000180d7ddc1e1-dddd5de8-86a7-4fc7-9166-01325ad39fcf-000000/W1pRsZJVyksLt4_RNlRKSZhqGGW0DFFUscu9S4vBayo=249) This email has been sent from Cell Press, a division of Elsevier Inc., 50 Hampshire Street, 5th Floor, Cambridge, MA 02139, USA. You are receiving this email because you signed up for email alerts for new issues of this journal. For all inquiries, problems or suggestions regarding this service, please contact [our support group.](%2F%2Fservice.elsevier.com%2Fapp%2Foverview%2Fcell-press%2F/1/01000180d7ddc1e1-dddd5de8-86a7-4fc7-9166-01325ad39fcf-000000/l1gDrRuX5aD1rQfSgLrIOy8a5hBPxi_-lLxVfaHpurw=249) Copyright © 2022 Elsevier Inc. All rights reserved. Subscription ID: c1bedb93-d933-486c-b094-8eaf812d893b Webuser ID: a55d53f7ab892786bd7dece67e5041dc06f264ea Results Event ID: b86d5e12-bdd2-40fb-ae4c-b31436d3803b