Neuron: April 20, 2022 (Volume 110, Issue 8)

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[Reward signals in the cerebellum: Origins, targets, and functional implications](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00180-5/1/01000180483f9292-2bc3fd35-5486-494c-b745-5d937954bd9c-000000/qhjQQ0_5X8XlPWphiP3vJqX0XOcFX4Vb62U3X8MDmKc=246) Kostadinov et al. [Hippocampal-amygdala memory circuits govern experience-dependent observational fear](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00058-7/1/01000180483f9292-2bc3fd35-5486-494c-b745-5d937954bd9c-000000/P2jJQwKoebAVWk2aVQ9B8iHgqfgv0z45BXCRTlOKVG4=246) Terranova et al. Online now --------------------------------------------------------------- [Signatures of rapid plasticity in hippocampal CA1 representations during novel experiences](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00262-8/1/01000180483f9292-2bc3fd35-5486-494c-b745-5d937954bd9c-000000/JRWzsbU9i0xHmf-uh7a3TybHNpwyvM3SPHfjAPiWDBA=246) Priestley et al. [The translational revolution of itch](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00267-7/1/01000180483f9292-2bc3fd35-5486-494c-b745-5d937954bd9c-000000/0n3pZ2fkru-LJXY57g5whU2ezKU2Td3ofhVX5lAyY-0=246) Kim [Glutamatergic synapses from the insular cortex to the basolateral amygdala encode observational pain](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00266-5/1/01000180483f9292-2bc3fd35-5486-494c-b745-5d937954bd9c-000000/fzloRHwjeYPt-aWTWCGc6gpimYt9GVIGaXABXVbq_1k=246) Zhang et al. [Regional Aβ-tau interactions promote onset and acceleration of Alzheimer's disease tau spreading](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00305-1/1/01000180483f9292-2bc3fd35-5486-494c-b745-5d937954bd9c-000000/GwkhB7J7sT6TSHZVTf2b2ehcVfZr3hpXrsFQBRk3eDU=246) Lee et al. Table of Contents Previews --------------------------------------------------------------- [Marmosets confirm that context is king](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00265-3%3Fdgcid=raven_jbs_etoc_email/1/01000180483f9292-2bc3fd35-5486-494c-b745-5d937954bd9c-000000/UXODhHCC7ATVazC0R_awB4R8rLHRZojYUkOl8_8lZJk=246) Katalin M. Gothard Neural responses to vocalizations are expected to depend on the sensory features of the stimulus. In this issue of Neuron, Jovanovic and colleagues show that call-responsive neurons in the prefrontal cortex of marmosets signal not only the auditory stimulus but also the social-behavioral context. [A neuropeptide regulates immunity across species](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00307-5%3Fdgcid=raven_jbs_etoc_email/1/01000180483f9292-2bc3fd35-5486-494c-b745-5d937954bd9c-000000/zXtSUZXLUL5hLkQ1dCU129oQGnGwj1sEpcu_9ytL_fw=246) Liwen Deng, Isaac M. Chiu Communication between the nervous system and immune system is important for regulating immunity in health and disease. Yu et al. (2022) show that neuropeptide Y and its homolog NPF serve as a “language” to facilitate crosstalk between these two systems across species, enabling neurons to downregulate harmful immune responses. [CLP1-dependent premature transcription termination opposes neurodegeneration](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00248-3%3Fdgcid=raven_jbs_etoc_email/1/01000180483f9292-2bc3fd35-5486-494c-b745-5d937954bd9c-000000/CJKQlakfW3fWCTYt-_KzEKQqe2pPdgC_6UepxXWWIQg=246) Michal R. Gdula, Magda Kopczyńska, Upasana Saha, Kinga Kamieniarz-Gdula Usage of alternative mRNA 3′ ends has profound functional consequences, particularly in the nervous system. In this issue of Neuron, LaForce et al. (2022) dissect the effect of CLP1 on mRNA 3′ end diversity in motor neuron models of neurodegeneration. [Why stay lonely packaged in a synaptic vesicle when you can be in good company? A GABA-glutamate gathering](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00306-3%3Fdgcid=raven_jbs_etoc_email/1/01000180483f9292-2bc3fd35-5486-494c-b745-5d937954bd9c-000000/CGe102n764BvlotH1yNzNGP2j3ciqEx9juS-pO8vO6k=246) Sarah Mondoloni, Manuel Mameli Neurons can release multiple neurotransmitters. Are they packaged in segregated pools of vesicles or within the same ones? In this issue of Neuron, Kim et al., 2022, examined features of GABA-glutamate co-release at basal ganglia to habenula synapses. [Preparatory neurons for building a nest](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00259-8%3Fdgcid=raven_jbs_etoc_email/1/01000180483f9292-2bc3fd35-5486-494c-b745-5d937954bd9c-000000/CI9LFefSy-Rbtc-tTFz4yZPHr6LK4mF4yRNDuCpjMSc=246) Onur Iyilikci, Marcelo O. Dietrich Mothers build nests in anticipation of the delivery of their offspring. How the brain coordinates this behavior is unknown. Topilko et al. (2022) demonstrate that nest building in pregnant females relies on the activity of peptidergic neurons in the Edinger-Westphal nucleus. NeuroView --------------------------------------------------------------- [A focus on the neural exposome](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00255-0%3Fdgcid=raven_jbs_etoc_email/1/01000180483f9292-2bc3fd35-5486-494c-b745-5d937954bd9c-000000/-pW5zBT131Vy1r0X4bUS2JuWL3Jp2LrBdfRoKPUyiZs=246) Amir P. Tamiz, Walter J. Koroshetz, Neel T. Dhruv, David A. Jett Many neurological disorders have complex etiologies that include noninheritable factors, collectively called the neural exposome. The National Institute of Neurological Disorders and Stroke is developing a new office with goals to advance our understanding of the multiple causes of neurological illness and to enable the development of more effective interventions. Perspective --------------------------------------------------------------- [Reward signals in the cerebellum: Origins, targets, and functional implications](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00180-5%3Fdgcid=raven_jbs_etoc_email/1/01000180483f9292-2bc3fd35-5486-494c-b745-5d937954bd9c-000000/ymJGZ2hKOjvvP38DYgArIa0LuDrGy87eNSVgkxAEdSQ=246) Dimitar Kostadinov, Michael Häusser Kostadinov and Häusser describe recent evidence for reward-related signals in the cerebellum. They discuss the relationship between these new findings and canonical dopaminergic reward signals and speculate about how the cerebellum and basal ganglia may work together to facilitate learning. Review --------------------------------------------------------------- [ApoE Cascade Hypothesis in the pathogenesis of Alzheimer’s disease and related dementias](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00229-X%3Fdgcid=raven_jbs_etoc_email/1/01000180483f9292-2bc3fd35-5486-494c-b745-5d937954bd9c-000000/cCJpdRsG7yjcsAj6CXIUuVQEPzUzvLJojnkH-LXwsqw=246) Yuka A. Martens, Na Zhao, Chia-Chen Liu, Takahisa Kanekiyo, Austin J. Yang, Alison M. Goate, David M. Holtzman, Guojun Bu In this review, Martens et al. propose a novel “ApoE Cascade Hypothesis,” which states that the biochemical and biophysical properties of apoE impact a cascade of events at the cellular and systems levels, ultimately leading to Alzheimer’s disease and age-related cognitive decline. Report --------------------------------------------------------------- [Behavioral context affects social signal representations within single primate prefrontal cortex neurons](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00059-9%3Fdgcid=raven_jbs_etoc_email/1/01000180483f9292-2bc3fd35-5486-494c-b745-5d937954bd9c-000000/YD7NbneWIvj7wkRw5NprXEnY4UWZc8L7g4nPREsEFDQ=246) Vladimir Jovanovic, Adam Ryan Fishbein, Lisa de la Mothe, Kuo-Fen Lee, Cory Thomas Miller Jovanovic and colleagues report that social signal processing in primate prefrontal cortex during traditional, head-restrained paradigms is not representative of the analogous process in natural communication. These findings suggest that some facets of primate social brain function can only be elucidated in the contexts in which they occur naturally. Articles --------------------------------------------------------------- [Neuron-derived neuropeptide Y fine-tunes the splenic immune responses](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00046-0%3Fdgcid=raven_jbs_etoc_email/1/01000180483f9292-2bc3fd35-5486-494c-b745-5d937954bd9c-000000/GUeoktoC6JrTL8GupU9b_emMd2nPxtB_gklxL4t4_xM=246) Jinsong Yu, Ke Xiao, Xiaohua Chen, Lulu Deng, Lu Zhang, Yue Li, Anran Gao, Junjun Gao, Chengchao Wu, Xinmei Yang, Qiudi Zhou, Jian Yang, Chenyu Bao, Jiaji Jiao, Sheng Cheng, Zhiqing Guo, Weize Xu, Xiaojian Cao, Zheng Guo, Jinxia Dai, Ji Hu, Zhenfang Fu, Gang Cao Yu, Xiao, et al. identify NPY/F as an ancient language for the crosstalk between the nervous system and the immune system in different species. Neuronal NPY is dramatically elevated during infection and plays an important role in fine-tuning immune balance in inflammatory response and autoimmune diseases. [Suppression of premature transcription termination leads to reduced mRNA isoform diversity and neurodegeneration](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00057-5%3Fdgcid=raven_jbs_etoc_email/1/01000180483f9292-2bc3fd35-5486-494c-b745-5d937954bd9c-000000/_Gln34YoQ2n6U_vZ5_duLCUsBuCPWKj0yBtfyzLmP7A=246) Geneva R. LaForce, Jordan S. Farr, Jingyi Liu, Cydni Akesson, Evren Gumus, Otis Pinkard, Helen C. Miranda, Katherine Johnson, Thomas J. Sweet, Ping Ji, Ai Lin, Jeff Coller, Polyxeni Philippidou, Eric J. Wagner, Ashleigh E. Schaffer LaForce et al. utilize motor neuron disease models to examine CLP1 function in mRNA 3′ end formation. CLP1 suppresses proximal polyadenylation to regulate mRNA isoform balance and maintain neuronal health. The authors find that diminished isoform diversity is a signature of neurodegenerative disease. [Conformational transitions and ligand-binding to a muscle-type nicotinic acetylcholine receptor](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00049-6%3Fdgcid=raven_jbs_etoc_email/1/01000180483f9292-2bc3fd35-5486-494c-b745-5d937954bd9c-000000/PBVUUBpbGEl6WSSsvc8clnZfnhKMU0Ltlyv9K8n0b9A=246) Eleftherios Zarkadas, Eva Pebay-Peyroula, Mackenzie John Thompson, Guy Schoehn, Tomasz Uchański, Jan Steyaert, Christophe Chipot, Francois Dehez, John Edward Baenziger, Hugues Nury Zarkadas et al. report agonist-free and agonist-bound structures of the muscle-type Torpedo nicotinic acetylcholine receptor. The structures shed light on the mechanism of channel activation, reveal the structural basis for the different affinities at two agonist sites, and explain why nicotine is a less potent activator of muscle receptors. [Co-packaging of opposing neurotransmitters in individual synaptic vesicles in the central nervous system](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00007-1%3Fdgcid=raven_jbs_etoc_email/1/01000180483f9292-2bc3fd35-5486-494c-b745-5d937954bd9c-000000/i93fwfOmMwF518-jGktEvvsabTzgt5lFVuuD-Jlk2OA=246) SeulAh Kim, Michael L. Wallace, Mahmoud El-Rifai, Alexa R. Knudsen, Bernardo L. Sabatini Somatostatin-expressing entopedunculus projections to the lateral habenula release glutamate and GABA. Using mathematical simulations and new electrophysiological approaches, Kim et al. show that both neurotransmitters are packaged into the same synaptic vesicles. Inhibitors of release, such as serotonin, affect both transmitters by reducing probability of release of these co-packaged vesicles. [Edinger-Westphal peptidergic neurons enable maternal preparatory nesting](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00048-4%3Fdgcid=raven_jbs_etoc_email/1/01000180483f9292-2bc3fd35-5486-494c-b745-5d937954bd9c-000000/8kV0S5S7gRYhyhYZLiy-joH3gZCmwLzNpryaSxGbvgs=246) Thomas Topilko, Silvina L. Diaz, Catarina M. Pacheco, Florine Verny, Charly V. Rousseau, Christoph Kirst, Charlotte Deleuze, Patricia Gaspar, Nicolas Renier Open Access Pregnancy hormones modulate many behaviors ensuring the survival of the upcoming litter. Topilko et al. describe a poorly studied population of midbrain peptidergic neurons that is sensitive to progesterone and is necessary for the onset of maternal preparatory nest building during pregnancy, before the pups are born. [Hypothalamus-habenula potentiation encodes chronic stress experience and drives depression onset](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00047-2%3Fdgcid=raven_jbs_etoc_email/1/01000180483f9292-2bc3fd35-5486-494c-b745-5d937954bd9c-000000/t3OWR1OcGk8uxoGxN6rIzEnmBgu8PrV9Q0X_CmbvEcA=246) Zhiwei Zheng, Chen Guo, Min Li, Liang Yang, Pengyang Liu, Xuliang Zhang, Yiqin Liu, Xiaonan Guo, Shuxia Cao, Yiyan Dong, Chunlei Zhang, Min Chen, Jiamin Xu, Hailan Hu, Yihui Cui Zheng et al. reveal a circuit mechanism for processing chronic stress. Potentiating hypothalamus-to-habenula pathway leads to lasting changes of emotional status. This study makes a significant stride toward the elucidation of the neural circuit mechanisms underlying chronic-stress-induced depression and sheds light on early interventions before depression onset. [Hippocampal-amygdala memory circuits govern experience-dependent observational fear](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00058-7%3Fdgcid=raven_jbs_etoc_email/1/01000180483f9292-2bc3fd35-5486-494c-b745-5d937954bd9c-000000/d5ACBAdUOFaKpOX-5pZ5ulp91s4OYxjrHygcjdof6EM=246) Joseph I. Terranova, Jun Yokose, Hisayuki Osanai, William D. Marks, Jun Yamamoto, Sachie K. Ogawa, Takashi Kitamura Open Access How do prior similar experiences and social familiarity with the demonstrator facilitate observational fear? In this study, Terranova et al. find that memory engram circuits in the hippocampal-amygdala networks encoding prior experiences integrate a perception-action coupling for experience-dependent enhancement of observational fear. 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