Neuron: January 5, 2022 (Volume 110, Issue 1)

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[Abstract submission deadline January 28, 2022](%2F%2Fwww.cell-symposia.com%2Fneuropsychiatric-disease-2022%2F/2/0100017e2bd0ce58-183ad518-b516-477e-919e-cc04a7c54ce3-000000/NgBoaMVAQgpHUKtl4H1MhIUuDbUsdSZ8yZntIwp4718=230) [Heliyon to receive its first Impact Factor in 2022](%2F%2Fwww.cell.com%2Fheliyon%2Fhome/1/0100017e2bd0ce58-183ad518-b516-477e-919e-cc04a7c54ce3-000000/1-pp6qKm1AfAQkkELPmUFFPBwboFpTk44s7_61NBr8s=230) We're pleased to announce that Heliyon, our all-science, open access journal, is now indexed in SCIE and will receive its first Impact Factor in 2022. [Learn more about the journal.](%2F%2Fwww.cell.com%2Fheliyon%2Fhome/2/0100017e2bd0ce58-183ad518-b516-477e-919e-cc04a7c54ce3-000000/Vvc4RMNaxmZcGv-RrJuKvv7z_mpvKZg-f_1363p786Y=230) Featured articles --------------------------------------------------------------- [Beyond t test and ANOVA: applications of mixed-effects models for more rigorous statistical analysis in neuroscience research](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(21)00845-X/1/0100017e2bd0ce58-183ad518-b516-477e-919e-cc04a7c54ce3-000000/UFkHDr-f8SnkSuOR6eI9FAIX-T7LYBW0wh24Q4JlGI4=230) Yu et al. [Compartmentalized dynamics within a common multi-area mesoscale manifold represent a repertoire of human hand movements](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(21)00770-4/1/0100017e2bd0ce58-183ad518-b516-477e-919e-cc04a7c54ce3-000000/xbFgHWbHX2yeYcIlEBzsr-U3OVn2_gCQs4iBNK9F4fo=230) Natraj et al. [An active vesicle priming machinery suppresses axon regeneration upon adult CNS injury](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(21)00775-3/1/0100017e2bd0ce58-183ad518-b516-477e-919e-cc04a7c54ce3-000000/9rVDDSb8sdT8QZwhzgUVCgZW3poMDFmyrYqnSrPNakY=230) Hilton et al. Online now --------------------------------------------------------------- [Local feedback inhibition tightly controls rapid formation of hippocampal place fields](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(21)00996-X/1/0100017e2bd0ce58-183ad518-b516-477e-919e-cc04a7c54ce3-000000/BaqPuRGPcMo1gHrHTmv8eFRQ1g_ONIDJ8g5Mce6CroI=230) Rolotti et al. [Glutamate in primary afferents is required for itch transmission](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(21)01015-1/1/0100017e2bd0ce58-183ad518-b516-477e-919e-cc04a7c54ce3-000000/bepXVOpG_3g6YA7J-OImF0L5N-xoeAwc8GLlsaKo5bU=230) Cui et al. [Make war not love: The neural substrate underlying a state-dependent switch in female social behavior](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(21)00995-8/1/0100017e2bd0ce58-183ad518-b516-477e-919e-cc04a7c54ce3-000000/mBGaw70VlXQlrL2h7YffhQgZvjPLUZQwTablsV7Tq1M=230) Liu et al. [Observational learning promotes hippocampal remote awake replay toward future reward locations](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(21)01013-8/1/0100017e2bd0ce58-183ad518-b516-477e-919e-cc04a7c54ce3-000000/tg5XnOYV08dBLZGRfsMdlwzdSmGROfUkM6F4TjLVzLk=230) Mou et al. Table of Contents Previews --------------------------------------------------------------- [The developmental roots of neurodegeneration](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(21)01012-6%3Fdgcid=raven_jbs_etoc_email/1/0100017e2bd0ce58-183ad518-b516-477e-919e-cc04a7c54ce3-000000/MUV88JA4-5f42Qy11Bsy2JdvSumtCR8w4_czvnvhntU=230) Morgan C. Stephens, Vicky Brandt, Juan Botas Neurodegenerative disorders can alter neural circuitry long before symptoms appear, but the path from early changes to later pathologies is obscure. In this issue of Neuron, Capizzi et al. (2021) show how early axonal growth defects in Huntington’s disease create vulnerability to later degeneration. [Defining the evolutionary and gene regulatory logic of vertebrate neuronal diversity](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(21)01030-8%3Fdgcid=raven_jbs_etoc_email/1/0100017e2bd0ce58-183ad518-b516-477e-919e-cc04a7c54ce3-000000/wFy5ulPx_BIf9q1TkBQ0S1V0imjMorKGhtSrANNgKUI=230) Luis de la Torre-Ubieta How is the exquisite cellular complexity of the vertebrate brain achieved? In this issue of Neuron, Closser et al. (2022) reveal that an expanded neuronal gene regulatory landscape may drive evolutionary cellular diversification by providing complex context and cell-specific control of effector genes. [A cellular stapler for memories](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(21)01014-X%3Fdgcid=raven_jbs_etoc_email/1/0100017e2bd0ce58-183ad518-b516-477e-919e-cc04a7c54ce3-000000/uVY1na3IoSJk7mWqcHGd9L7iUoqU4OyDnJNjYVMuimQ=230) Michael Brecht In this issue of Neuron, Zhao et al. (2022) describe the effects of plateau potentials, discharges common in hippocampus but rare in cortex. They show that plateau potentials can staple a nonspatial tag about a plan to the hippocampal place map. Memory stapling is a key functionality that cortex cannot perform without hippocampus [A series of unforced events](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(21)01027-8%3Fdgcid=raven_jbs_etoc_email/1/0100017e2bd0ce58-183ad518-b516-477e-919e-cc04a7c54ce3-000000/qkv04cqkrk-O0tJJguNpRUU8a0bblPO6BQjVGpsxNHI=230) Paul Miller In this issue of Neuron, Recanatesi et al. (2022) show the need for, then find evidence of, directed noise fluctuations within cortical spike trains. Such fluctuations can reproduce the observed variability in timing of transitions between discrete activity patterns while maintaining their reliable sequential order as rats engage in self-initiated actions. [Distributed yet compartmentalized neural dynamics of hand actions](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(21)01038-2%3Fdgcid=raven_jbs_etoc_email/1/0100017e2bd0ce58-183ad518-b516-477e-919e-cc04a7c54ce3-000000/agQLcUmvQqkvCSWncD6fh-mjfUpZMVset4Psh_14Kw4=230) Hansjörg Scherberger In this issue of Neuron, Natraj et al. (2021) demonstrate that finger and hand grasping movements are represented in the human fronto-parietal grasp network in a compartmentalized fashion. The movements are encoded in a distributed network that is preserved across various hand actions. The neural dynamics are specific to particular hand movements, leading to movement-specific submanifolds in the network. Spotlight --------------------------------------------------------------- [Brain ventricles as windows into brain development and disease](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(21)01017-5%3Fdgcid=raven_jbs_etoc_email/1/0100017e2bd0ce58-183ad518-b516-477e-919e-cc04a7c54ce3-000000/p4hzECxI3s40qHfAjJIFnp-ag9gh23sSazEJIx6JcjA=230) Phan Q. Duy, Pasko Rakic, Seth L. Alper, William E. Butler, Christopher A. Walsh, Nenad Sestan, Daniel H. Geschwind, Sheng Chih Jin, Kristopher T. Kahle Dilation of the fluid-filled cerebral ventricles (ventriculomegaly) characterizes hydrocephalus and is frequently seen in autism and schizophrenia. Recent work suggests that the genomic study of congenital hydrocephalus may be unexpectedly fertile ground for revealing insights into neural stem cell regulation, human cerebrocortical development, and pathogenesis of neuropsychiatric disease. Meeting Report --------------------------------------------------------------- [Toward next-generation primate neuroscience: A collaboration-based strategic plan for integrative neuroimaging](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(21)00783-2%3Fdgcid=raven_jbs_etoc_email/1/0100017e2bd0ce58-183ad518-b516-477e-919e-cc04a7c54ce3-000000/O7SP3XkHeIopVhShUb0QGNGQ9KHsVCDVhztg-3GHUBQ=230) The PRIMatE Data and Resource Exchange (PRIME-DRE) Global Collaboration Workshop and Consortium Building on opportunities in open science, the PRIME-DRE non-human primate neuroimaging community at a Global Collaboration Workshop generated a collaboration-based strategic plan presented in this meeting report that is broadly cross-species and data integrative to guide neuroscientific innovation and discovery. Primer --------------------------------------------------------------- [Beyond t test and ANOVA: applications of mixed-effects models for more rigorous statistical analysis in neuroscience research](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(21)00845-X%3Fdgcid=raven_jbs_etoc_email/1/0100017e2bd0ce58-183ad518-b516-477e-919e-cc04a7c54ce3-000000/wy9X5gnpMBOss7i3phtp7IloPpm6MuJpBGeYu9G9MEw=230) Zhaoxia Yu, Michele Guindani, Steven F. Grieco, Lujia Chen, Todd C. Holmes, Xiangmin Xu In this Primer, Yu et al. introduce linear and generalized mixed-effects models for improved statistical analysis in neuroscience research and provide clear instruction on how to recognize when they are needed and how to apply them. Articles --------------------------------------------------------------- [Developmental defects in Huntington’s disease show that axonal growth and microtubule reorganization require NUMA1](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(21)00863-1%3Fdgcid=raven_jbs_etoc_email/1/0100017e2bd0ce58-183ad518-b516-477e-919e-cc04a7c54ce3-000000/yMPWeUO3PH-cG6RlcDhi_CefqO-BHqghM23-TNgBpp4=230) Mariacristina Capizzi, Rémi Carpentier, Eric Denarier, Annie Adrait, Rayane Kassem, Marina Mapelli, Yohann Couté, Sandrine Humbert Capizzi et al. show that Huntington’s disease (HD) limits axonal growth during development. The microtubules in the axonal growth cones are disorganized in HD because of NUMA1 downregulation. Restoring NUMA1 levels rescues axonal growth in HD mice. [An active vesicle priming machinery suppresses axon regeneration upon adult CNS injury](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(21)00775-3%3Fdgcid=raven_jbs_etoc_email/1/0100017e2bd0ce58-183ad518-b516-477e-919e-cc04a7c54ce3-000000/Rdc5D77dudePeoVq4q0XOy-PwX8lacJW-sMZcsf7VMQ=230) Brett J. Hilton, Andreas Husch, Barbara Schaffran, Tien-chen Lin, Emily R. Burnside, Sebastian Dupraz, Max Schelski, Jisoo Kim, Johannes Alexander Müller, Susanne Schoch, Cordelia Imig, Nils Brose, Frank Bradke Open Access Combining genetic, pharmacogenetic, pharmacological, and transcriptomic approaches with live-cell, super-resolution, and 3-dimensional two-photon imaging, Hilton et al. demonstrate that critical components of the presynaptic transmitter release machinery actively inhibit axon growth. Munc13, a presynaptic active zone protein essential for synaptic transmission, suppresses axon regeneration following adult CNS injury. [An expansion of the non-coding genome and its regulatory potential underlies vertebrate neuronal diversity](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(21)00782-0%3Fdgcid=raven_jbs_etoc_email/1/0100017e2bd0ce58-183ad518-b516-477e-919e-cc04a7c54ce3-000000/yr2NdoT7NEUSfM5LUKFH5clBe4oCrFQkM4Esel8zofw=230) Michael Closser, Yuchun Guo, Ping Wang, Tulsi Patel, Sumin Jang, Jennifer Hammelman, Joriene C. De Nooij, Rachel Kopunova, Esteban O. Mazzoni, Yijun Ruan, David K. Gifford, Hynek Wichterle Closser et al. show that neuronal genes are associated with highly complex regulatory systems in expanded non-coding genomic domains. Neuronal enhancers are distributed broadly and utilized sparsely in cell-type- and cell-stage-specific patterns. Acquisition of new enhancers might be a fundamental process underlying the evolutionary increase in cellular complexity. [Structural mechanisms of assembly, permeation, gating, and pharmacology of native human rod CNG channel](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(21)00774-1%3Fdgcid=raven_jbs_etoc_email/1/0100017e2bd0ce58-183ad518-b516-477e-919e-cc04a7c54ce3-000000/hCJ8Wc3mBfsOSH_S7W7SHQ2WEzafmBQPIZUpPCn285M=230) Jing Xue, Yan Han, Weizhong Zeng, Youxing Jiang Xue et al. present the high-resolution structures of the human rod CNGA1/B1 heterotetrameric channel in apo, cGMP-bound, cAMP-bound, and L-cis-Diltiazem-blocked states. These structures elucidate the structural mechanisms underlying the subunit stoichiometry, the asymmetrical gating upon cGMP activation, and the unique pharmacological property of the native rod CNG channel. [Rapid synaptic plasticity contributes to a learned conjunctive code of position and choice-related information in the hippocampus](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(21)00771-6%3Fdgcid=raven_jbs_etoc_email/1/0100017e2bd0ce58-183ad518-b516-477e-919e-cc04a7c54ce3-000000/T-4gZhfIlY3MM-g1Vb8aI4ch5tBKOgE5jrjLn6ZCAK0=230) Xinyu Zhao, Ching-Lung Hsu, Nelson Spruston Open Access Zhao et al. demonstrate that rapid plasticity in CA1 pyramidal cells creates cellular responses carrying information about position and choice-related factors during a cued, two-choice virtual navigation task. Prior learning is necessary to produce the upstream code for trial type, and subsequent plasticity enables flexible readout of the code. [An inferior-superior colliculus circuit controls auditory cue-directed visual spatial attention](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(21)00772-8%3Fdgcid=raven_jbs_etoc_email/1/0100017e2bd0ce58-183ad518-b516-477e-919e-cc04a7c54ce3-000000/c2bQmcPY4hOaPTTCGZ-xuQ-DPwtk2nx7bJu1PVAiRao=230) Fei Hu, Yang Dan Hu and Dan established an auditory-cue-directed visual spatial attention task for mice and identified a midbrain source of attention signal. The delay activity of neurons in the nucleus of the brachium of the inferior colliculus is crucial for task performance and attentional modulation in the superior colliculus and visual cortex. [Visual thalamocortical mechanisms of waking state-dependent activity and alpha oscillations](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(21)00773-X%3Fdgcid=raven_jbs_etoc_email/1/0100017e2bd0ce58-183ad518-b516-477e-919e-cc04a7c54ce3-000000/9NZ9cU2XTftB7L_R50sH45FDmyFHYEgvuRwdJS8K8qc=230) Dennis B. Nestvogel, David A. McCormick Nestvogel and McCormick performed intra- and extracellular recordings in the visual thalamus and visual cortex of mice to reveal a crucial role of thalamocortical interactions in shaping movement/arousal-related signals in visual cortex and in regulating a 3–5 Hz oscillation thought to be an evolutionary precursor to the primate alpha rhythm. [Metastable attractors explain the variable timing of stable behavioral action sequences](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(21)00779-0%3Fdgcid=raven_jbs_etoc_email/1/0100017e2bd0ce58-183ad518-b516-477e-919e-cc04a7c54ce3-000000/J-gGpv3nT4qFF7W1pPQRJUewp-JhrNfmG1VdfG3uTGY=230) Stefano Recanatesi, Ulises Pereira-Obilinovic, Masayoshi Murakami, Zachary Mainen, Luca Mazzucato Open Access Self-initiated actions in freely moving rats can be predicted by specific ensemble activity patterns in the secondary motor cortex (M2). Variability in action timing can be explained by metastable attractors in a network model of M2. Transitions between attractors are generated by low-dimensional correlated variability, empirically verified in M2. [Compartmentalized dynamics within a common multi-area mesoscale manifold represent a repertoire of human hand movements](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(21)00770-4%3Fdgcid=raven_jbs_etoc_email/1/0100017e2bd0ce58-183ad518-b516-477e-919e-cc04a7c54ce3-000000/aiWwctig9eAZAscS-BTT8ZlUc_R5vVAODMNDNav4baQ=230) Nikhilesh Natraj, Daniel B. Silversmith, Edward F. Chang, Karunesh Ganguly How does the human brain flexibly support a remarkably diverse repertoire of hand movements? Natraj et al. show that mesoscale activity, for movements ranging from grasps to finger individuation, lie within a common multi-area manifold spanning the “grasp network.” However, latent dynamics within this manifold were movement specific and compartmentalized into distinct behaviorally relevant submanifolds. 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