Neuron: August 19, 2020 (Volume 107, Issue 4)

[Cell press](%2F%2Fwww.cell.com/1/010001740775a944-524f08e2-e7df-4a37-8949-c2d7df1e9e76-000000/LqMI1pfHECEDyyqJx2ofCoSa3mkPhM5OLJ7XrbQoePQ=154) [Facebook](%2F%2Ffacebook.com%2Fcellpress/1/010001740775a944-524f08e2-e7df-4a37-8949-c2d7df1e9e76-000000/jKRfC6ig7vXLukoVpQEv1QziI3AuY8lW7Pua9HUXOUM=154) [Twitter](%2F%2Ftwitter.com%2FNeuroCellPress/1/010001740775a944-524f08e2-e7df-4a37-8949-c2d7df1e9e76-000000/rQfSzTN4uvYNrZin1kisGNWmPjutwFZNTDy_czKv5xI=154) [Youtube](%2F%2Fwww.youtube.com%2Fuser%2Fcellvideoabstracts/1/010001740775a944-524f08e2-e7df-4a37-8949-c2d7df1e9e76-000000/IJF2Riti4AXCH3VpqWv_-a4acnmuriV9y5wJV4ZYvHQ=154) [Weibo](%2F%2Fweibo.com%2FCellPress/1/010001740775a944-524f08e2-e7df-4a37-8949-c2d7df1e9e76-000000/Ei05QBwvGtGMFUAVihm2zry9KNdarSY8ZRKthd4wzAA=154) [Issue cover](%2F%2Fwww.cell.com%2Fneuron%2Fissue%3Fpii=S0896627319X00173/1/010001740775a944-524f08e2-e7df-4a37-8949-c2d7df1e9e76-000000/i_u76DZqIbubbh2klU5FDFVsez56Xo2aKhl1I53ulg0=154) [Aug 19, 2020](%2F%2Fwww.cell.com%2Fneuron%2Fissue%3Fpii=S0896627319X00173/2/010001740775a944-524f08e2-e7df-4a37-8949-c2d7df1e9e76-000000/ausv6cbL2YHcf0VmoaWI8gTsfm5fjnEYxazwfSrbzpQ=154) Vol. 107, Iss. 4 [Website](%2F%2Fwww.cell.com%2Fneuron%2Fhome%3Fdgcid=raven_jbs_etoc_email/1/010001740775a944-524f08e2-e7df-4a37-8949-c2d7df1e9e76-000000/70EFjWUCUILzeFJSEvlANcrNmjHrUms-fnQ3oY6ejs0=154) [Table of Contents](%2F%2Fwww.cell.com%2Fneuron%2Fissue%3Fpii=S0896627319X00173%26dgcid=raven_jbs_etoc_email/1/010001740775a944-524f08e2-e7df-4a37-8949-c2d7df1e9e76-000000/oB-E0FOQ5KcPZDVnyIxIhLFvSnfant9a5AROC6SCp0o=154) [Online Now](%2F%2Fwww.cell.com%2Fneuron%2Fnewarticles%3Fdgcid=raven_jbs_etoc_email/1/010001740775a944-524f08e2-e7df-4a37-8949-c2d7df1e9e76-000000/aJpEtgPVrqvQb5gOW8JPtsgJopZVcnuaZhdCDn2oJnA=154) [Archive](%2F%2Fwww.cell.com%2Fneuron%2Farchive%3Fdgcid=raven_jbs_etoc_email/1/010001740775a944-524f08e2-e7df-4a37-8949-c2d7df1e9e76-000000/BwLzlGJfl_WjjoDlPJMVN20ehT9FKyDP1T3NKLp3tvk=154) Highlights Announcements --------------------------------------------------------------- [Cell Reports Medicine: See what's coming. Know what's working.](%2F%2Fwww.cell.com%2Fcell-reports-medicine%3Futm_campaign=STMJ_1591820503_SISSUE%26utm_medium=email%26utm_source=Other%26dgcid=STMJ_1591820503_SISSUE/1/010001740775a944-524f08e2-e7df-4a37-8949-c2d7df1e9e76-000000/KG7RCodLClvG1nJTrDqXjlyUyE-PXFoElIWyXXo67As=154) Cell Reports Medicine is an open-access journal publishing cutting-edge research in translational and clinical biomedical sciences that inform and influence human health and medicine. [Read the latest research!](%2F%2Fwww.cell.com%2Fcell-reports-medicine%3Futm_campaign=STMJ_1591820503_SISSUE%26utm_medium=email%26utm_source=Other%26dgcid=STMJ_1591820503_SISSUE/2/010001740775a944-524f08e2-e7df-4a37-8949-c2d7df1e9e76-000000/hcfMlDPbNVBiuhXfWu0za6X0nRLUic-UWn14l2z295E=154) [What makes STAR Protocols different?](%2F%2Fstar-protocols.cell.com%2Fprotocols/1/010001740775a944-524f08e2-e7df-4a37-8949-c2d7df1e9e76-000000/zyz1j-D8GtbJRx17Dd8LlVtxjSk5CGd-DznM4Dl1TF0=154) Our protocols are peer-reviewed and designed with feedback from researchers like you. [Learn more and read our latest protocols.](%2F%2Fstar-protocols.cell.com%2Fprotocols/2/010001740775a944-524f08e2-e7df-4a37-8949-c2d7df1e9e76-000000/Wwefc5dEaCdZxlIU4W-5NZGKjIrnM0RX8ibe17Bt0XI=154) [Trends Collection on One Health](%2F%2Fwww.cell.com%2Freviews%2Fcollections%2Fone-health%3Futm_campaign=STMJ_1594232660_SISSUE%26utm_medium=email%26utm_source=Other%26dgcid=STMJ_1594232660_SISSUE/1/010001740775a944-524f08e2-e7df-4a37-8949-c2d7df1e9e76-000000/NM2fGNa7qKJps1R6ys-g8tvmyWJZU9kRh6ggcixLOFg=154) This Trends collection discusses the transmission and control of a wide range of zoonotic pathogens, including helminths, protozoans, bacteria, and viruses, with the latest findings of the current SARS-CoV-2 pandemic. [Read the collection today](%2F%2Fwww.cell.com%2Freviews%2Fcollections%2Fone-health%3Futm_campaign=STMJ_1594232660_SISSUE%26utm_medium=email%26utm_source=Other%26dgcid=STMJ_1594232660_SISSUE/2/010001740775a944-524f08e2-e7df-4a37-8949-c2d7df1e9e76-000000/49n9pdr0TIji1noWmtwBs4V5CU0t1v-SPgirLNV4fV0=154) Featured Review --------------------------------------------------------------- [Deep Reinforcement Learning and Its Neuroscientific Implications](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(20)30468-2/1/010001740775a944-524f08e2-e7df-4a37-8949-c2d7df1e9e76-000000/ZvdXmAarAiVrR0CnmOaP65dJHbjegeUWDC51wCVROhY=154) Botvinick et al. Featured NeuroView --------------------------------------------------------------- [Dialogue Across Chasm: Are Psychology and Neurophysiology Incompatible?](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(20)30533-X/1/010001740775a944-524f08e2-e7df-4a37-8949-c2d7df1e9e76-000000/GtW3Gw9YZZoq-4t-eFTOU5LxoDRxQ0dWVKt7u3mUFbo=154) Marom et al. NeuroResource --------------------------------------------------------------- [Wireless Optogenetic Stimulation of Oxytocin Neurons in a Semi-natural Setup Dynamically Elevates Both Pro-social and Agonistic Behaviors](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(20)30397-4/1/010001740775a944-524f08e2-e7df-4a37-8949-c2d7df1e9e76-000000/_4nGcqmmFRxldc1jsze-u4JRqCl_ULbm0N3_40XQ5Rg=154) Anpilov et al. Online Now --------------------------------------------------------------- [Synthesis of Conserved Odor Object Representations in a Random, Divergent-Convergent Network](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(20)30573-0/1/010001740775a944-524f08e2-e7df-4a37-8949-c2d7df1e9e76-000000/ZLGU2cv9pGOtFPUk4vfsMelsVhx9A7nfuskO_RZk8gM=154) Endo et al. [Slow Drift of Neural Activity as a Signature of Impulsivity in Macaque Visual and Prefrontal Cortex](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(20)30565-1/1/010001740775a944-524f08e2-e7df-4a37-8949-c2d7df1e9e76-000000/RPx3BVTqSFgBVgftg2E2G1YWqrjczMtvV6cOfVmJb9Y=154) Cowley et al. [Transcriptional Reprogramming of Distinct Peripheral Sensory Neuron Subtypes after Axonal Injury](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(20)30570-5/1/010001740775a944-524f08e2-e7df-4a37-8949-c2d7df1e9e76-000000/zDmgTNXAWZiepERWQzh8OOr4LuFChPL5SQ7y3S9qDak=154) Renthal et al. [Brainwide Genetic Sparse Cell Labeling to Illuminate the Morphology of Neurons and Glia with Cre-Dependent MORF Mice](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(20)30563-8/1/010001740775a944-524f08e2-e7df-4a37-8949-c2d7df1e9e76-000000/S7O1LqBOLCYrHdhBnN7OKHXzmbUnZwBgKb6Eag_Zals=154) Veldman et al. Table of Contents Previews --------------------------------------------------------------- [Oxytocin Discrepancies in Social Dynamics](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(20)30571-7%3Fdgcid=raven_jbs_etoc_email/1/010001740775a944-524f08e2-e7df-4a37-8949-c2d7df1e9e76-000000/msMTmI7oisQONQq-5oNcJ-LRB_4zO1aCtxA6iXpQ2ag=154) Federica Maltese, Francesco Papaleo Social group dynamics are highly complex. In this issue of Neuron, Anpilov et al. use a novel wireless optogenetics device to demonstrate that the repeated stimulation of oxytocin neurons modulates pro-social and agonistic behaviors in a time- and context-dependent manner. [All Talk, No Assembly: Voltage-Gated Calcium Channels Do Not Mediate Active Zone Formation](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(20)30572-9%3Fdgcid=raven_jbs_etoc_email/1/010001740775a944-524f08e2-e7df-4a37-8949-c2d7df1e9e76-000000/o1XEgyfgCQVwm9rzFxv4C2FigIWDzEVSolYah5x6JAY=154) Elisa B. Frankel, Peri T. Kurshan How synapses assemble remains unknown. In this issue of Neuron, Held et al. (2020) demonstrate that Cav2-type voltage-gated calcium channels do not mediate presynaptic assembly. Moreover, the channel-associated protein α2δ localizes independently, suggesting additional functions for this auxiliary protein. [“The One Who Guides” Nigral Neuron Migration](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(20)30574-2%3Fdgcid=raven_jbs_etoc_email/1/010001740775a944-524f08e2-e7df-4a37-8949-c2d7df1e9e76-000000/PWRIGtY6ipilsfCFD2RJx1CdSXzQam6W8wTbWZpDx4c=154) Rajeshwar Awatramani, Martin Lévesque In this issue, Brignani, Raj, et al. show that Netrin-1 from distinct sources controls neuronal migrations into the substantia nigra. Remarkably, one source of Netrin −1 is forebrain axons traversing the midbrain, and this is required for proper GABAergic neuronal migration into the substantia nigra pars reticulata. [Why Have Two When One Will Do? Comparing Task Representations across Amygdala and Prefrontal Cortex in Single Neurons and Neuronal Populations](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(20)30603-6%3Fdgcid=raven_jbs_etoc_email/1/010001740775a944-524f08e2-e7df-4a37-8949-c2d7df1e9e76-000000/33Ld7qZY5D4JXOUHnYJscC1D0Asp9q-eErz6XXaruo8=154) Alexander D. Jacob, Sheena A. Josselyn Many brain areas represent aspects of learned behavior. How do representations differ between regions? In this issue of Neuron, Kyriazi et al. (2020) show how the amygdala and prefrontal cortex use distinct strategies to code features of a complex task. NeuroView --------------------------------------------------------------- [Dialogue Across Chasm: Are Psychology and Neurophysiology Incompatible?](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(20)30533-X%3Fdgcid=raven_jbs_etoc_email/1/010001740775a944-524f08e2-e7df-4a37-8949-c2d7df1e9e76-000000/M3twv1o7vakqSFOl4I9pz6cZ80MzpB4fZivD7VuovWU=154) Shimon Marom To establish a genuine scientific discourse, we must accept a long due departure from the habit of neatly arranging things in a hierarchy where “macroscopic” psychological mystery awaits explanation in terms of “microscopic” neural objects. Instead, a relational scientific methodology is wanted, accompanied by a dialogic mode of conversation between the disciplines. Review --------------------------------------------------------------- [Deep Reinforcement Learning and Its Neuroscientific Implications](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(20)30468-2%3Fdgcid=raven_jbs_etoc_email/1/010001740775a944-524f08e2-e7df-4a37-8949-c2d7df1e9e76-000000/kds64OpUsLsze_kxzjs8ldHzDQDVs3hfpmnD15o6Z6M=154) Matthew Botvinick, Jane X. Wang, Will Dabney, Kevin J. Miller, Zeb Kurth-Nelson Recent advances in artificial intelligence have unified the fields of reinforcement learning and deep learning. The result, deep reinforcement learning, has far-reaching implications for neuroscience. Botvinick et al. introduce deep reinforcement learning and identify diverse opportunities it creates for brain research. NeuroResources --------------------------------------------------------------- [Direct Readout of Neural Stem Cell Transgenesis with an Integration-Coupled Gene Expression Switch](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(20)30407-4%3Fdgcid=raven_jbs_etoc_email/1/010001740775a944-524f08e2-e7df-4a37-8949-c2d7df1e9e76-000000/rubxsRcIsFtPa9-8N9Iv1ZnkkkMFHezmaTRgjpFTKmU=154) Takuma Kumamoto, Franck Maurinot, Raphaëlle Barry-Martinet, Célia Vaslin, Sandrine Vandormael-Pournin, Mickaël Le, Marion Lerat, Dragos Niculescu, Michel Cohen-Tannoudji, Alexandra Rebsam, Karine Loulier, Stéphane Nedelec, Samuel Tozer, Jean Livet Open Access Kumamoto et al. introduce iOn, a genetic switch that conditions exogenous transgene expression to integration in the host cell genome by DNA transposition. This system radically simplifies stable transgenesis with one or multiple plasmid vectors, opening new options to genetically manipulate cells in cultured systems and model organisms. [Magnetoelectric Materials for Miniature, Wireless Neural Stimulation at Therapeutic Frequencies](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(20)30365-2%3Fdgcid=raven_jbs_etoc_email/1/010001740775a944-524f08e2-e7df-4a37-8949-c2d7df1e9e76-000000/7x6Ayymi2K7o9S3r-hinluAOUbHoxc3sfubIHysXZIg=154) Amanda Singer, Shayok Dutta, Eric Lewis, Ziying Chen, Joshua C. Chen, Nishant Verma, Benjamin Avants, Ariel K. Feldman, John O’Malley, Michael Beierlein, Caleb Kemere, Jacob T. Robinson Magnetoelectric (ME) materials enable tiny remotely powered neural stimulators. Singer et al. demonstrate that alternating magnetic fields can power millimeter-sized ME stimulators in freely moving rodents. The extreme miniaturization made possible by this technology lays the foundation for a new class of minimally invasive bioelectronics. [Wireless Optogenetic Stimulation of Oxytocin Neurons in a Semi-natural Setup Dynamically Elevates Both Pro-social and Agonistic Behaviors](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(20)30397-4%3Fdgcid=raven_jbs_etoc_email/1/010001740775a944-524f08e2-e7df-4a37-8949-c2d7df1e9e76-000000/chh0rzrnpI34FqYIHKrZg7vARh7_7_RBhAscrtgoJFo=154) Sergey Anpilov, Yair Shemesh, Noa Eren, Hala Harony-Nicolas, Asaf Benjamin, Julien Dine, Vinícius E.M. Oliveira, Oren Forkosh, Stoyo Karamihalev, Rosa-Eva Hüttl, Noa Feldman, Ryan Berger, Avi Dagan, Gal Chen, Inga D. Neumann, Shlomo Wagner, Ofer Yizhar, Alon Chen Open Access Anpilov et al. present a lightweight, easily assembled wireless optogenetic device compatible with group-housed mice in a complex environment. Using this approach, they show that repeated activation of oxytocin neurons elicits both pro-social and aggressive behaviors over time, emphasizing the role of the social setting in modulating behavior. Report --------------------------------------------------------------- [Efficient Coding by Midget and Parasol Ganglion Cells in the Human Retina](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(20)30399-8%3Fdgcid=raven_jbs_etoc_email/1/010001740775a944-524f08e2-e7df-4a37-8949-c2d7df1e9e76-000000/vm7mwmOSY8MvJGpYDuW83WJYFzglPBiMq291XHSHMWo=154) Florentina Soto, Jen-Chun Hsiang, Rithwick Rajagopal, Kisha Piggott, George J. Harocopos, Steven M. Couch, Philip Custer, Josh L. Morgan, Daniel Kerschensteiner Soto et al. combine large-scale multi-electrode array recordings of human retinas and computational modeling to show that ON and OFF midget and ON and OFF parasol ganglion cells efficiently encode luminance contrast in our environment. Articles --------------------------------------------------------------- [Synapse and Active Zone Assembly in the Absence of Presynaptic Ca2+ Channels and Ca2+ Entry](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(20)30401-3%3Fdgcid=raven_jbs_etoc_email/1/010001740775a944-524f08e2-e7df-4a37-8949-c2d7df1e9e76-000000/0jcbtG4DspPjAfa_ZYuH6kchda1-wUaWRIHChY54wH0=154) Richard G. Held, Changliang Liu, Kunpeng Ma, Austin M. Ramsey, Tyler B. Tarr, Giovanni De Nola, Shan Shan H. Wang, Jiexin Wang, Arn M.J.M. van den Maagdenberg, Toni Schneider, Jianyuan Sun, Thomas A. Blanpied, Pascal S. Kaeser CaV2 channels provide Ca2+ for triggering neurotransmitter release at central synapses. Held et al. remove all CaV2s and Ca2+ entry and find that synaptic protein nano-assemblies persist and synapse ultrastructure is unimpaired despite abolishing synaptic transmission. Rescue experiments establish that CaV2 C-termini are important for channel anchoring at active zones. [Remotely Produced and Axon-Derived Netrin-1 Instructs GABAergic Neuron Migration and Dopaminergic Substantia Nigra Development](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(20)30406-2%3Fdgcid=raven_jbs_etoc_email/1/010001740775a944-524f08e2-e7df-4a37-8949-c2d7df1e9e76-000000/sWjGdlpoYHFROO0V2Ye23euEqzyk1oLGtfBoA9al6tE=154) Sara Brignani, Divya D.A. Raj, Ewoud R.E. Schmidt, Özge Düdükcü, Youri Adolfs, Anna A. De Ruiter, Mateja Rybiczka-Tesulov, Marieke G. Verhagen, Christiaan van der Meer, Mark H. Broekhoven, Juan A. Moreno-Bravo, Laurens M. Grossouw, Emilie Dumontier, Jean-François Cloutier, Alain Chédotal, R. Jeroen Pasterkamp Brignani et al. devise intersectional genetic tools to dissect the mechanisms of substantia nigra (SN) development. Their data implicate Netrin-1 in the neuronal subtype-specific migration of midbrain dopamine neurons and show that Netrin-1 acts as a remotely produced and axon-derived guidance cue for the migration of SN GABAergic neurons. [A Distributed Neural Code in the Dentate Gyrus and in CA1](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(20)30391-3%3Fdgcid=raven_jbs_etoc_email/1/010001740775a944-524f08e2-e7df-4a37-8949-c2d7df1e9e76-000000/TQuWU-ZdzX5wqK_TdQx_9vk_9wvH_j9LGHQ4T6Uj6rQ=154) Fabio Stefanini, Lyudmila Kushnir, Jessica C. Jimenez, Joshua H. Jennings, Nicholas I. Woods, Garret D. Stuber, Mazen A. Kheirbek, René Hen, Stefano Fusi Using high-resolution calcium imaging and machine learning techniques, Stefanini et al. studied how information about position, direction of motion, and speed is represented in the hippocampus. They show that neurons cooperate to encode this information, and that cells with easily interpretable responses are not necessarily the most important ones. [Different Multidimensional Representations across the Amygdalo-Prefrontal Network during an Approach-Avoidance Task](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(20)30429-3%3Fdgcid=raven_jbs_etoc_email/1/010001740775a944-524f08e2-e7df-4a37-8949-c2d7df1e9e76-000000/z66sAWzBDwJmJVKEtbvdNCeRSotM8j0roKWHzXGVNY0=154) Pinelopi Kyriazi, Drew B. Headley, Denis Paré Both the PL and BLA regulate emotional behaviors and have similar extrinsic connectivity. However, it is unclear whether they encode distinct aspects of emotional events. Kyriazi et al. show that neurons in these structures encode similar emotional variables but at the population level tend to represent different task dimensions. [Cooling of Medial Septum Reveals Theta Phase Lag Coordination of Hippocampal Cell Assemblies](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(20)30392-5%3Fdgcid=raven_jbs_etoc_email/1/010001740775a944-524f08e2-e7df-4a37-8949-c2d7df1e9e76-000000/jztsoz6YjYv8PeyXbTRyuF7myuyMANyhA1pgsxlanHg=154) Peter Christian Petersen, György Buzsáki Petersen et al. demonstrate that cooling of the medial septum slows theta oscillation and increases choice errors without affecting spatial features of pyramidal neurons. Cooling affects distance-time, but not distance-theta phase, compression. The findings reveal that cell assemblies are organized by theta phase and not by external (clock) time. [Neural Trajectories in the Supplementary Motor Area and Motor Cortex Exhibit Distinct Geometries, Compatible with Different Classes of Computation](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(20)30366-4%3Fdgcid=raven_jbs_etoc_email/1/010001740775a944-524f08e2-e7df-4a37-8949-c2d7df1e9e76-000000/FY0pO2KDQLORzZuvfxNVTpiueRenHffsmp0CihB82zU=154) Abigail A. Russo, Ramin Khajeh, Sean R. Bittner, Sean M. Perkins, John P. Cunningham, L.F. Abbott, Mark M. Churchland The supplementary motor area is believed to guide action by “looking ahead” in time. Russo et al. formalize this idea and predict a basic property that neural activity must have to serve that purpose. That property is present, explains diverse features of activity, and distinguishes higher- from lower-level motor areas. Correction --------------------------------------------------------------- [Ankyrin Is An Intracellular Tether for TMC Mechanotransduction Channels](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(20)30575-4%3Fdgcid=raven_jbs_etoc_email/1/010001740775a944-524f08e2-e7df-4a37-8949-c2d7df1e9e76-000000/7nJXZ7uOrSWgC6AbZQESdaoCJFw48R6i-dMD52N5WUk=154) Yi-Quan Tang, Sol Ah Lee, Mizanur Rahman, Siva A. Vanapalli, Hang Lu, William R. Schafer Open Access [Update Your Profile](%2F%2Fwww.cell.com%2Faction%2FshowPreferences%3FmenuTab=Alerts%26code=cell-site/1/010001740775a944-524f08e2-e7df-4a37-8949-c2d7df1e9e76-000000/QgSq9PiVbvMDVLEqeyiwxkt-yVXWqT3tbvw3M4MzupU=154) [Terms and Conditions](%2F%2Fwww.elsevier.com%2Flegal%2Felsevier-website-terms-and-conditions/1/010001740775a944-524f08e2-e7df-4a37-8949-c2d7df1e9e76-000000/YGd8Q7tApBwomPdUpHWqaJSuJG_t4vFCTF7ObAVAmyI=154) [Privacy Policy](%2F%2Fwww.elsevier.com%2Flegal%2Fprivacy-policy/1/010001740775a944-524f08e2-e7df-4a37-8949-c2d7df1e9e76-000000/7plwo8lnIo2SUlNYzwTe9_6T3FIeAduX_IrZC_QPVlI=154) [Follow this link to unsubscribe.](%2F%2Fwww.cell.com%2Falerts%2Funsubscribe%3FsubscriptionID=c1bedb93-d933-486c-b094-8eaf812d893b%26hash=eeca2f294f987df4d4ae56abbd699bf6e686193b/1/010001740775a944-524f08e2-e7df-4a37-8949-c2d7df1e9e76-000000/LsARw5_7N8ssZOJGogVjRo-ZfkdIoDh4mB4_Yb7hR9Q=154) This email has been sent from Cell Press, a division of Elsevier Inc., 50 Hampshire Street, 5th Floor, Cambridge, MA 02139, USA. You are receiving this email because you signed up for email alerts for new issues of this journal. For all inquiries, problems or suggestions regarding this service, please contact [our support group.](%2F%2Fservice.elsevier.com%2Fapp%2Foverview%2Fcell-press%2F/1/010001740775a944-524f08e2-e7df-4a37-8949-c2d7df1e9e76-000000/AE-_EN-H5AA1PcvuaGCYRUqNCtIVA8whPypGJz19paY=154) Copyright © 2020 Elsevier Inc. All rights reserved. Subscription ID: c1bedb93-d933-486c-b094-8eaf812d893b Webuser ID: a55d53f7ab892786bd7dece67e5041dc06f264ea Results Event ID: 7b178aed-4b36-4e79-b84c-86f5c69678f0