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Vol. 104, Iss. 5
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Featured Review
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[Quiescence of Adult Mammalian Neural Stem Cells: A Highly Regulated Rest](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(19)30800-1/1/0100016ed25c73ad-c18fcc93-c362-4525-a1e4-ba03b261a9f3-000000/O_6LiukShUEU-dXbQ8LixXMPWvA=138)
Urbán et al.
Featured Article
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[Patient-Tailored, Connectivity-Based Forecasts of Spreading Brain Atrophy](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(19)30743-3/1/0100016ed25c73ad-c18fcc93-c362-4525-a1e4-ba03b261a9f3-000000/lVkn2KSQrY4iJz_KXLqSpJXce-g=138)
Brown et al.
[Complementary Genetic Targeting and Monosynaptic Input Mapping Reveal Recruitment and Refinement of Distributed Corticostriatal Ensembles by Cocaine](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(19)30927-4/1/0100016ed25c73ad-c18fcc93-c362-4525-a1e4-ba03b261a9f3-000000/wDFsi61PgUDfzz5YQaY4bnpzaEk=138)
Wall et al.
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[Alpha Synchrony and the Neurofeedback Control of Spatial Attention](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(19)30964-X/1/0100016ed25c73ad-c18fcc93-c362-4525-a1e4-ba03b261a9f3-000000/bRKmdo0TNfNm2UTz585Gbu-ms_U=138)
Bagherzadeh et al.
[Binary Fate Choice between Closely Related Interneuronal Types Is Determined by a Fezf1-Dependent Postmitotic Transcriptional Switch](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(19)30965-1/1/0100016ed25c73ad-c18fcc93-c362-4525-a1e4-ba03b261a9f3-000000/-6ocJhzvCxmYwi6k54Cq6cO26M8=138)
Peng et al.
Video Abstract
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%2F%2Fyoutu.be%2FI2ghvmVY50Y/1/0100016ed25c73ad-c18fcc93-c362-4525-a1e4-ba03b261a9f3-000000/97OXBXeYFv-KvAyZpE-roHkNxaw=138
[Human/Mouse Chimeric Brains Reveal How Human Nerve Cells Wire into Brain Circuits](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(19)30850-5/1/0100016ed25c73ad-c18fcc93-c362-4525-a1e4-ba03b261a9f3-000000/0RphXgw85Skf_lzjeX03hNwozRM=138)
Human neurons integrate as single cells into the mouse cortex where they display human-like prolonged development and functionally integrate into the visual circuits of the mouse brain.
Table of Contents
Previews
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[Relax, Donât RAN Translate It](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(19)30977-8%3Fdgcid=raven_jbs_etoc_email/1/0100016ed25c73ad-c18fcc93-c362-4525-a1e4-ba03b261a9f3-000000/CurxgXtl8YehVu93JuwuopTQLAY=138)
Katherine M. Wilson, Bhavana Muralidharan, Adrian M. Isaacs
The (GGGGCC)n repeat expansion in C9orf72, which is the most common cause of frontotemporal dementia and amyotrophic lateral sclerosis, is translated through repeat-associated non-AUG (RAN) translation. In this issue of Neuron, Cheng et al. (2019) report that the helicase DDX3X, which unwinds (or relaxes) RNA, suppresses RAN translation and toxicity.
[Signal Amplification in Drosophila Olfactory Receptor Neurons](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(19)31007-4%3Fdgcid=raven_jbs_etoc_email/1/0100016ed25c73ad-c18fcc93-c362-4525-a1e4-ba03b261a9f3-000000/_9QZ_jzMhbUfQI7bL-jXqeLS8tQ=138)
Byoung Soo Kim, Greg S.B. Suh
Olfactory receptor neurons (ORNs) transform scant chemical inputs into significant neural signals. This transformation requires signal amplification. In this issue of Neuron, Ng et al. (2019) identified a mechanism by which the signals evoked by pheromones are amplified in the ORNs that selectively promote courtship behavior in Drosophila.
[TREK for High-Speed and High-Frequency Conduction through the Axon](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(19)30978-X%3Fdgcid=raven_jbs_etoc_email/1/0100016ed25c73ad-c18fcc93-c362-4525-a1e4-ba03b261a9f3-000000/oR6VWWQ5LeGjHYj0_K7PpYrkC7o=138)
Pablo Ávalos Prado, Guillaume Sandoz
In this issue of Neuron, Kanda et al. (2019) find that the two-pore domain potassium channels TRAAK and TREK1 drive axonal action potential repolarization for high-speed and high-frequency nervous impulses in mammalian myelinated nerves.
Review
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[Quiescence of Adult Mammalian Neural Stem Cells: A Highly Regulated Rest](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(19)30800-1%3Fdgcid=raven_jbs_etoc_email/1/0100016ed25c73ad-c18fcc93-c362-4525-a1e4-ba03b261a9f3-000000/yKljvkbrbhjJ3nCVTz-CYAwdII8=138)
Noelia Urbán, Isabelle Maria Blomfield, François Guillemot
Urbán et al. review our current understanding of stem cell quiescence in the adult mammalian brain and ask how quiescence is regulated and whether quiescent neural stem cells represent heterogeneous cell populations.
Report
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[The Low-Dimensional Neural Architecture of Cognitive Complexity Is Related to Activity in Medial Thalamic Nuclei](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(19)30775-5%3Fdgcid=raven_jbs_etoc_email/1/0100016ed25c73ad-c18fcc93-c362-4525-a1e4-ba03b261a9f3-000000/DC8J_57ASHzSqimSX2Sel4yV3FU=138)
James M. Shine, Luke J. Hearne, Michael Breakspear, Kai Hwang, Eli J. Müller, Olaf Sporns, Russell A. Poldrack, Jason B. Mattingley, Luca Cocchi
Shine et al. demonstrate that cognitive complexity reconfigures the low-dimensional state space of the human brain. The low-dimensional trajectories of whole-brain activity dissociate correct and error trials and relate to activity within the medial and posterior thalamic nuclei.
Articles
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[Patient-Tailored, Connectivity-Based Forecasts of Spreading Brain Atrophy](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(19)30743-3%3Fdgcid=raven_jbs_etoc_email/1/0100016ed25c73ad-c18fcc93-c362-4525-a1e4-ba03b261a9f3-000000/5LPnbJKQMSx9ZKuhsi4sVEQ2VlM=138)
Jesse A. Brown, Jersey Deng, John Neuhaus, Isabel J. Sible, Ana C. Sias, Suzee E. Lee, John Kornak, Gabe A. Marx, Anna M. Karydas, Salvatore Spina, Lea T. Grinberg, Giovanni Coppola, Dan H. Geschwind, Joel H. Kramer, Maria Luisa Gorno-Tempini, Bruce L. Miller, Howard J. Rosen, William W. Seeley
Brown et al. show that unique atrophy âepicentersâ can be detected in individual patients with behavioral variant frontotemporal dementia and semantic variant primary progressive aphasia and used in a connectivity-based model to accurately predict the longitudinal spread of atrophy.
[Stress-Induced Cellular Clearance Is Mediated by the SNARE Protein ykt6 and Disrupted by α-Synuclein](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(19)30774-3%3Fdgcid=raven_jbs_etoc_email/1/0100016ed25c73ad-c18fcc93-c362-4525-a1e4-ba03b261a9f3-000000/677siCWGO3F6bboHXKzd7w-uAIc=138)
Leah K. Cuddy, Willayat Y. Wani, Martino L. Morella, Caleb Pitcairn, Kotaro Tsutsumi, Kristina Fredriksen, Craig J. Justman, Tom N. Grammatopoulos, Nandkishore R. Belur, Friederike Zunke, Aarthi Subramanian, Amira Affaneh, Peter T. Lansbury Jr., Joseph R. Mazzulli
Cuddy et al. found that the SNARE protein ykt6 plays a crucial role in proteostasis and lysosomal function by enhancing hydrolase trafficking under stressful conditions. Parkinsonâs disease α-synuclein impedes ykt6, causing imbalanced proteostasis and self-propagating protein accumulation. Ykt6 can be therapeutically targeted by farnesyltransferase inhibitors that restore trafficking and lysosomal function.
[CRISPR-Cas9 Screens Identify the RNA Helicase DDX3X as a Repressor of C9ORF72 (GGGGCC)n Repeat-Associated Non-AUG Translation](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(19)30776-7%3Fdgcid=raven_jbs_etoc_email/1/0100016ed25c73ad-c18fcc93-c362-4525-a1e4-ba03b261a9f3-000000/FrONr3kyxcn_TheLcJt5KHuS3PM=138)
Weiwei Cheng, Shaopeng Wang, Zhe Zhang, David W. Morgens, Lindsey R. Hayes, Soojin Lee, Bede Portz, Yongzhi Xie, Baotram V. Nguyen, Michael S. Haney, Shirui Yan, Daoyuan Dong, Alyssa N. Coyne, Junhua Yang, Fengfan Xian, Don W. Cleveland, Zhaozhu Qiu, Jeffrey D. Rothstein, James Shorter, Fen-Biao Gao, Michael C. Bassik, Shuying Sun
DPR proteins produced by the unconventional translation of expanded RNA repeats contribute to neurodegeneration in C9ORF72-ALS/FTD. Cheng and Wang et al. identify DDX3X as a repressor of r(GGGGCC)n translation. Elevating DDX3X decreases DPRs, rescues pathological phenotypes, and improves neuronal survival.
[Chronic Stress Induces Activity, Synaptic, and Transcriptional Remodeling of the Lateral Habenula Associated with Deficits in Motivated Behaviors](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(19)30778-0%3Fdgcid=raven_jbs_etoc_email/1/0100016ed25c73ad-c18fcc93-c362-4525-a1e4-ba03b261a9f3-000000/-VeMP-sqMEMeVNaH-v_ZfjIW08o=138)
Ignas Cerniauskas, Jochen Winterer, Johannes W. de Jong, David Lukacsovich, Hongbin Yang, Fawwad Khan, James R. Peck, Sophie K. Obayashi, Varoth Lilascharoen, Byung Kook Lim, Csaba Földy, Stephan Lammel
Chronic stress is a major risk factor for depression. Cerniauskas et al. identify a lateral habenula subcircuit involved in chronic stress-induced increased passive coping and reduced motivated behaviors. Single-cell transcriptomics reveal potential gene targets associated with this specific behavioral phenotype.
[Complementary Genetic Targeting and Monosynaptic Input Mapping Reveal Recruitment and Refinement of Distributed Corticostriatal Ensembles by Cocaine](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(19)30927-4%3Fdgcid=raven_jbs_etoc_email/1/0100016ed25c73ad-c18fcc93-c362-4525-a1e4-ba03b261a9f3-000000/7ugfIhuUhGB3Mju98KY7GtoVCUc=138)
Nicholas R. Wall, Peter A. Neumann, Kevin T. Beier, Ava K. Mokhtari, Liqun Luo, Robert C. Malenka
Wall et al. demonstrate that a cocaine experience recruits diverse populations of cortical and dorsal striatal neurons into coherent, persistent ensembles with heightened synaptic transmission. Chronic cocaine induces pathway-specific circuit remodeling, which impacts the expression of a drug-related behavior.
[Pum2 Shapes the Transcriptome in Developing Axons through Retention of Target mRNAs in the Cell Body](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(19)30741-X%3Fdgcid=raven_jbs_etoc_email/1/0100016ed25c73ad-c18fcc93-c362-4525-a1e4-ba03b261a9f3-000000/P0bByf0hzKCfGbbQE559QKDrzNs=138)
José C. Martínez, Lisa K. Randolph, Daniel Maxim Iascone, Helena F. Pernice, Franck Polleux, Ulrich Hengst
Local translation of a specific subset of mRNAs in axons is critical for neuronal development. Martínez et al. report that the RNA-binding protein Pumilio 2 controls which transcripts are transported into axons by retaining its target mRNAs in the soma.
[Amplification of Drosophila Olfactory Responses by a DEG/ENaC Channel](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(19)30747-0%3Fdgcid=raven_jbs_etoc_email/1/0100016ed25c73ad-c18fcc93-c362-4525-a1e4-ba03b261a9f3-000000/qywYWVt93o9n5RmMXkb67dRzBAk=138)
Renny Ng, Secilia S. Salem, Shiuan-Tze Wu, Meilin Wu, Hui-Hao Lin, Andrew K. Shepherd, William J. Joiner, Jing W. Wang, Chih-Ying Su
In primary sensory neurons, little was known about whether and how ionotropic inputs are amplified. Focusing on Drosophila courtship-promoting olfactory neurons, Ng et al. identify an amplification mechanism downstream of Or47b and Ir84a receptor channels. Upon odor stimulation, receptor-mediated calcium influx serves as a second messenger that activates Pickpocket 25 (PPK25), DEG/ENaC, whose expression is upregulated by a reproductive hormone to modulate the gain of neuronal output.
[TREK-1 and TRAAK Are Principal K+ Channels at the Nodes of Ranvier for Rapid Action Potential Conduction on Mammalian Myelinated Afferent Nerves](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(19)30773-1%3Fdgcid=raven_jbs_etoc_email/1/0100016ed25c73ad-c18fcc93-c362-4525-a1e4-ba03b261a9f3-000000/jMAnXR3iXEREniKZ9iaaqbcQ_90=138)
Hirosato Kanda, Jennifer Ling, Sotatsu Tonomura, Koichi Noguchi, Sadis Matalon, Jianguo G. Gu
Kanda et al. studied ion channels at the nodes of Ranvier (NRs) on rat myelinated afferent nerves. They discovered that thermally sensitive K2P channels, including TREK-1 and TRAAK, are clustered at NRs to secure high-speed and high-frequency nerve conduction.
[Xenotransplanted Human Cortical Neurons Reveal Species-Specific Development and Functional Integration into Mouse Visual Circuits](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(19)30850-5%3Fdgcid=raven_jbs_etoc_email/1/0100016ed25c73ad-c18fcc93-c362-4525-a1e4-ba03b261a9f3-000000/pKu4HWkdOQ-02I3EiphvFrXfgSY=138)
Daniele Linaro, Ben Vermaercke, Ryohei Iwata, Arjun Ramaswamy, Baptiste Libé-Philippot, Leila Boubakar, Brittany A. Davis, Keimpe Wierda, Kristofer Davie, Suresh Poovathingal, Pier-Andrée Penttila, Angéline Bilheu, Lore De Bruyne, David Gall, Karl-Klaus Conzelmann, Vincent Bonin, Pierre Vanderhaeghen
Open Access
Human cortical neurons integrate as single cells in the mouse cortex and display human-like prolonged development, indicating cell-intrinsic mechanisms. Following maturation in the visual cortex, xenotransplanted human neurons display decorrelated activity and tuned responses to visual stimuli that are similar to host neurons.
[Three Rostromedial Tegmental Afferents Drive Triply Dissociable Aspects of Punishment Learning and Aversive Valence Encoding](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(19)30746-9%3Fdgcid=raven_jbs_etoc_email/1/0100016ed25c73ad-c18fcc93-c362-4525-a1e4-ba03b261a9f3-000000/oOCbJrNhMMB_ovO0yh9GygpYlRI=138)
Hao Li, Peter J. Vento, Jeffrey Parrilla-Carrero, Dominika Pullmann, Ying S. Chao, Maya Eid, Thomas C. Jhou
Survival requires one to obtain rewards but also cease reward seeking when it incurs high costs or punishment. Li, Vento, et al. show that punishment learning requires highly coordinated activity patterns in distinct afferents and efferents of the rostromedial tegmental nucleus.
[Postural Representations of the Hand in the Primate Sensorimotor Cortex](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(19)30777-9%3Fdgcid=raven_jbs_etoc_email/1/0100016ed25c73ad-c18fcc93-c362-4525-a1e4-ba03b261a9f3-000000/wzBG6Dk1_HTB7ZHsZPsYMAFHfCE=138)
James M. Goodman, Gregg A. Tabot, Alex S. Lee, Aneesha K. Suresh, Alexander T. Rajan, Nicholas G. Hatsopoulos, Sliman Bensmaia
Goodman et al. show that, during grasping, individual neurons in the somatosensory and motor cortices of primates track the time-varying angles of joints distributed over the entire hand. This postural representation of the hand is well suited to support stereognosis.
[Neural Correlates of Optimal Multisensory Decision Making under Time-Varying Reliabilities with an Invariant Linear Probabilistic Population Code](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(19)30744-5%3Fdgcid=raven_jbs_etoc_email/1/0100016ed25c73ad-c18fcc93-c362-4525-a1e4-ba03b261a9f3-000000/FN1AnFHJv1cs8YVjaU-eUlo3XZg=138)
Han Hou, Qihao Zheng, Yuchen Zhao, Alexandre Pouget, Yong Gu
Hou et al. reveal that activity in the macaque lateral intraparietal area is consistent with a theoretical framework (ilPPC) that implements optimal multisensory decision making with a simple accumulation of time-varying momentary evidence with time-invariant synaptic weights.
Corrections
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[A Large Panel of Isogenic APP and PSEN1 Mutant Human iPSC Neurons Reveals Shared Endosomal Abnormalities Mediated by APP β-CTFs, Not Aβ](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(19)30973-0%3Fdgcid=raven_jbs_etoc_email/1/0100016ed25c73ad-c18fcc93-c362-4525-a1e4-ba03b261a9f3-000000/XrSOKRWVGdndw4Dupl-yFhFn_QA=138)
Dylan Kwart, Andrew Gregg, Claudia Scheckel, Elisabeth A. Murphy, Dominik Paquet, Michael Duffield, John Fak, Olav Olsen, Robert B. Darnell, Marc Tessier-Lavigne
[Human Olfaction without Apparent Olfactory Bulbs](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(19)30981-X%3Fdgcid=raven_jbs_etoc_email/1/0100016ed25c73ad-c18fcc93-c362-4525-a1e4-ba03b261a9f3-000000/bdU1F8dW5DJJ703xFJuWhyxhWh0=138)
Tali Weiss, Timna Soroka, Lior Gorodisky, Sagit Shushan, Kobi Snitz, Reut Weissgross, Edna Furman-Haran, Thijs Dhollander, Noam Sobel
Open Access
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