Neuron: September 19, 2018 (Volume 99, Issue 6)

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[Still time to register.](%2F%2Fwww.cell-symposia.com%2Fneurotechnologies-2018%2F/2/01000165f285739a-62cd7780-6d30-4aac-8ed3-164b533d7da7-000000/ed5ndf-524T1jH8wfGBYlbKVbHA=75) [Free Webinar – Probing Epigenomic Heterogeneity in Single Cells](%2F%2Fwww.workcast.com%2Fregister%3Fcpak=9531950695209324%26referrer=etoc/1/01000165f285739a-62cd7780-6d30-4aac-8ed3-164b533d7da7-000000/TgbvuE9iEmS5ocUO9SRggFVxxI4=75) Speakers: Jason Buenrostro, Broad Institute; William Greenleaf, Stanford University & Jay Shendure, University of Washington October 10, 2018; 12 p.m. ET Claim your free registration for live or on-demand access today! [Click here to register.](%2F%2Fwww.workcast.com%2Fregister%3Fcpak=9531950695209324%26referrer=etoc/2/01000165f285739a-62cd7780-6d30-4aac-8ed3-164b533d7da7-000000/WrHD4BbdUm8EmTU-5_HsSFR5XHY=75) [Congratulations to the 2018 Lasker Award winners!](%2F%2Fwww.cell.com%2Fcell%2Flasker-2018/1/01000165f285739a-62cd7780-6d30-4aac-8ed3-164b533d7da7-000000/-CDEtq5sAoci4cI61mhOwfrKe8c=75) Read a special collection of papers from the winners, [now online](%2F%2Fwww.cell.com%2Fcell%2Flasker-2018/2/01000165f285739a-62cd7780-6d30-4aac-8ed3-164b533d7da7-000000/Ia6gAe_vOAJZAF_gNW6FQY205Lk=75) Featured Article --------------------------------------------------------------- [Big-Loop Recurrence within the Hippocampal System Supports Integration of Information across Episodes](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30682-2/1/01000165f285739a-62cd7780-6d30-4aac-8ed3-164b533d7da7-000000/gz82z7ctvK1yFro3UWZXuY_Ue4A=75) Raphael Koster, Martin J. Chadwick, Yi Chen, David Berron, Andrea Banino, Emrah Düzel, Demis Hassabis, Dharshan Kumaran Featured Review --------------------------------------------------------------- [Molecular Dynamics Simulation for All](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30684-6/1/01000165f285739a-62cd7780-6d30-4aac-8ed3-164b533d7da7-000000/pHQLP0ptlo5mEy91fykdRYEI-ng=75) Scott A. Hollingsworth, Ron O. Dror Online Now --------------------------------------------------------------- [Distinct Laminar Processing of Local and Global Context in Primate Primary Visual Cortex](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30723-2/1/01000165f285739a-62cd7780-6d30-4aac-8ed3-164b533d7da7-000000/ANMBfaAE-2BgX4yzfUuxELEmpsY=75) Bijanzadeh et al. [Menin Deficiency Leads to Depressive-like Behaviors in Mice by Modulating Astrocyte-Mediated Neuroinflammation](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30736-0/1/01000165f285739a-62cd7780-6d30-4aac-8ed3-164b533d7da7-000000/B5cnm_O69jI492BUkmxkCs54ixw=75) Leng et al. Video Abstract --------------------------------------------------------------- %2F%2Fyoutu.be%2FzQB_3fpwh-g/1/01000165f285739a-62cd7780-6d30-4aac-8ed3-164b533d7da7-000000/uABgI-JDLQQ_TQvEF2uCShL3Rz8=75 [Neuropeptides Modulate Behavioral Arousal in Worms](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30676-7/1/01000165f285739a-62cd7780-6d30-4aac-8ed3-164b533d7da7-000000/qTZfONKk34wxj_9CLqVQJSb2qkU=75) Arousal is an important conserved behavioral state in which animals show increased sensory responsiveness and locomotor hyperactivity. In this video abstract, [Chew et al.](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30676-7/2/01000165f285739a-62cd7780-6d30-4aac-8ed3-164b533d7da7-000000/2pOG7ogBUNUddOiyBNBvLyDWwJc=75) describe how this process is controlled by communication via neuropeptides in a small nematode worm. %2F%2Fyoutu.be%2F1qF2NUBylhA/1/01000165f285739a-62cd7780-6d30-4aac-8ed3-164b533d7da7-000000/0g44WIEx3uErr4ZuQtMHo3uE480=75 [Cannabinoid Receptors Control Incidental Learning](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30687-1/1/01000165f285739a-62cd7780-6d30-4aac-8ed3-164b533d7da7-000000/ZvJdVK3PZHXNuy1sMOALtVxm4Ws=75) Cannabinoid CB1 receptors signaling in the hippocampus, a brain structure involved in memory processes, underlines the mammalian ability to associate randomly encountered stimuli, allowing future inferred memories and possibly explaining seemingly ungrounded responses toward certain cues. The authors thank Franck Burglen and Marie Lods for the movie preparation and illustration. Table of Contents Previews --------------------------------------------------------------- [The Multi-pronged Regulation of Adult Neurogenesis by Forkhead Box O Family Members](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30784-0%3Fdgcid=raven_jbs_etoc_email/1/01000165f285739a-62cd7780-6d30-4aac-8ed3-164b533d7da7-000000/ukh4i0z7WK-519c6qkXZFaHH2sM=75) Timal S. Kannangara, Diane C. Lagace In this issue of Neuron, Schäffner et al. (2018) discover multiple effects of the Forkhead Box O (FoxO) transcription factor family on the different stages of adult neurogenesis, including the genesis of dendrites and spines regulated by FoxO-dependent autophagic activity. [Peripheral Kappa Opioid Receptor Signaling Takes on a Central Role](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30779-7%3Fdgcid=raven_jbs_etoc_email/1/01000165f285739a-62cd7780-6d30-4aac-8ed3-164b533d7da7-000000/r3f90ENr_lD48MfcvKb7IeKx5lo=75) Paul V. Naser, Rohini Kuner With the current unmet demand for effective analgesics and the opioid crisis, pain relief without major central adverse effects is highly appealing. In this issue of Neuron, Snyder et al. (2018) report on the localization, functions, and therapeutic potential of kappa opioid receptors in peripheral sensory neurons. [The Enigmatic “Indirect Pathway” of the Basal Ganglia: A New Role](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30769-4%3Fdgcid=raven_jbs_etoc_email/1/01000165f285739a-62cd7780-6d30-4aac-8ed3-164b533d7da7-000000/ZZNN-7p6DHiCenL8D803fO6r51s=75) Sten Grillner Goal-directed behavior is processed in the dorsomedial striatum. Using a probabilistic reward paradigm, Nonomura et al. (2018) show that indirect pathway neurons signal when an action is incorrect and it is time to switch strategies, while the direct pathway remains active with a correct action. [Resolving Memory Circuits with Layer-Dependent fMRI](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30777-3%3Fdgcid=raven_jbs_etoc_email/1/01000165f285739a-62cd7780-6d30-4aac-8ed3-164b533d7da7-000000/RIFYWNJXaxyTPa0sEj4bVnfkfSA=75) Jozien Goense Memory encoding and retrieval require directional exchange of information between different areas in the medial temporal lobe. In this issue of Neuron, Koster et al. (2018) use high-resolution fMRI combined with state-of-the-art data analysis methods to trace the information flow in memory circuits in hippocampus and entorhinal cortex. Q&A --------------------------------------------------------------- [Richard Axel](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30776-1%3Fdgcid=raven_jbs_etoc_email/1/01000165f285739a-62cd7780-6d30-4aac-8ed3-164b533d7da7-000000/0iQ8Vxx-VP86xmgVJ4Xp-gLZEZw=75) Richard Axel has always had an eclectic interest in biology, which led to his current work on the perception of odors. In an interview with Neuron, he recalls the joys of his lab and discusses the potential for theorists to help uncover the logic behind the language of the brain. NeuroView --------------------------------------------------------------- [The Value of Undergraduate Teaching for Research Scientists](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30778-5%3Fdgcid=raven_jbs_etoc_email/1/01000165f285739a-62cd7780-6d30-4aac-8ed3-164b533d7da7-000000/IjWx83PDdFX--AQ7Zbx9URCTmqE=75) Marla B. Feller Teaching undergraduates is part of the academic commitment for many neuroscience faculty. While some scientists view this as a major distraction from research, teaching is of high value, both in training young scientists and for informing one’s own scientific investigations. Perspective --------------------------------------------------------------- [A Cortical Pathogenic Theory of Parkinson’s Disease](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30626-3%3Fdgcid=raven_jbs_etoc_email/1/01000165f285739a-62cd7780-6d30-4aac-8ed3-164b533d7da7-000000/VUU4jfg_m6tWQS1yzUb-1ewGLl4=75) Guglielmo Foffani, José A. Obeso Current pathogenic theories of Parkinson’s disease postulate a bottom-up progression, from the periphery to the neocortex. Foffani and Obeso offer a top-down perspective, proposing that corticostriatal activity may act as a somatotopic “stressor” for nigrostriatal neurons. Review --------------------------------------------------------------- [Molecular Dynamics Simulation for All](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30684-6%3Fdgcid=raven_jbs_etoc_email/1/01000165f285739a-62cd7780-6d30-4aac-8ed3-164b533d7da7-000000/-VohWXKLEUqCE-hfq-1u8EgpgvY=75) Scott A. Hollingsworth, Ron O. Dror Hollingsworth and Dror review modern molecular dynamics (MD) simulations, with an emphasis on how such simulations complement wet-lab experiments. MD simulations capture biomolecular motion in atomic detail and have come into widespread use because of recent technological and scientific advances. Report --------------------------------------------------------------- [Cadherin Combinations Recruit Dendrites of Distinct Retinal Neurons to a Shared Interneuronal Scaffold](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30722-0%3Fdgcid=raven_jbs_etoc_email/1/01000165f285739a-62cd7780-6d30-4aac-8ed3-164b533d7da7-000000/51MCeAnuNjTmubBFqs6SjHDvQT8=75) Xin Duan, Arjun Krishnaswamy, Mallory A. Laboulaye, Jinyue Liu, Yi-Rong Peng, Masahito Yamagata, Kenichi Toma, Joshua R. Sanes Duan et al. show that 15 members of the classical cadherin family are expressed in retinal circuits that compute direction of motion. They reveal that six cadherins act combinatorially to regulate dendritic lamination and connectivity of circuit elements. Articles --------------------------------------------------------------- [Muskelin Coordinates PrPC Lysosome versus Exosome Targeting and Impacts Prion Disease Progression](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30683-4%3Fdgcid=raven_jbs_etoc_email/1/01000165f285739a-62cd7780-6d30-4aac-8ed3-164b533d7da7-000000/GTn_vQQsZtBxAl17avKc5a5T8eI=75) Frank F. Heisler, Yvonne Pechmann, Ines Wieser, Hermann C. Altmeppen, Leonhard Veenendaal, Mary Muhia, Michaela Schweizer, Markus Glatzel, Susanne Krasemann, Matthias Kneussel Heisler et al. demonstrate that prion protein intracellular transport is important for the progression of prion disease. They identify a regulatory mechanism of bidirectional prion protein vesicle trafficking and propose a novel transport pathway that connects intracellular lysosomal degradation with extracellular exosome trafficking under neurodegenerative conditions. [Reducing Astrocyte Calcium Signaling In Vivo Alters Striatal Microcircuits and Causes Repetitive Behavior](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30688-3%3Fdgcid=raven_jbs_etoc_email/1/01000165f285739a-62cd7780-6d30-4aac-8ed3-164b533d7da7-000000/ReYPjUlbYuUyUvUnxMoCMnWzOlg=75) Xinzhu Yu, Anna M.W. Taylor, Jun Nagai, Peyman Golshani, Christopher J. Evans, Giovanni Coppola, Baljit S. Khakh The Khakh laboratory evaluated the consequences of genetically attenuating astrocyte calcium signaling in the adult mouse striatum in vivo. They discovered excessive self-grooming phenotypes, the mechanisms of which were explored at the molecular, cellular, and in vivo levels. [FoxO Function Is Essential for Maintenance of Autophagic Flux and Neuronal Morphogenesis in Adult Neurogenesis](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30720-7%3Fdgcid=raven_jbs_etoc_email/1/01000165f285739a-62cd7780-6d30-4aac-8ed3-164b533d7da7-000000/mZt_pzJQJvXUrAkZNdOk0HThp24=75) Iris Schäffner, Georgia Minakaki, M. Amir Khan, Elli-Anna Balta, Ursula Schlötzer-Schrehardt, Tobias J. Schwarz, Ruth Beckervordersandforth, Beate Winner, Ashley E. Webb, Ronald A. DePinho, Jihye Paik, Wolfgang Wurst, Jochen Klucken, D. Chichung Lie Schäffner et al. identify FoxO transcription factors as critical regulators of autophagic flux in adult hippocampal neurogenesis and show that FoxO-dependent autophagic flux is necessary for morphological maturation and synaptic integration of adult-born hippocampal neurons. [Developmental Coordination during Olfactory Circuit Remodeling in Drosophila](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30648-2%3Fdgcid=raven_jbs_etoc_email/1/01000165f285739a-62cd7780-6d30-4aac-8ed3-164b533d7da7-000000/OcoWdT2dKj7NI-uPC9tMYS6TbJQ=75) Oded Mayseless, Dominic S. Berns, Xiaomeng M. Yu, Thomas Riemensperger, André Fiala, Oren Schuldiner Developmental remodeling is crucial for stereotypic neural circuit formation. Mayseless et al. describe a neural circuit in Drosophila that undergoes coordinated remodeling. They show that neurons within the same circuit interact via neuronal activity and Ca2+/Calmodulin signaling to coordinate remodeling. [Presynaptic Biogenesis Requires Axonal Transport of Lysosome-Related Vesicles](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30677-9%3Fdgcid=raven_jbs_etoc_email/1/01000165f285739a-62cd7780-6d30-4aac-8ed3-164b533d7da7-000000/WOrVpht7mOI63SDalw0ORDdmvWc=75) Anela Vukoja, Ulises Rey, Astrid G. Petzoldt, Christoph Ott, Dennis Vollweiter, Christine Quentin, Dymtro Puchkov, Eric Reynolds, Martin Lehmann, Svea Hohensee, Stefanie Rosa, Reinhard Lipowsky, Stephan J. Sigrist, Volker Haucke Synapse formation and maintenance require axonal transport of presynaptic cargoes. The identity of the precursor organelles involved has remained largely elusive. Vukoja et al. show that presynaptic vesicle and active zone proteins undergo anterograde axonal co-transport in lysosome-related vesicles. [An Afferent Neuropeptide System Transmits Mechanosensory Signals Triggering Sensitization and Arousal in C. elegans](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30676-7%3Fdgcid=raven_jbs_etoc_email/1/01000165f285739a-62cd7780-6d30-4aac-8ed3-164b533d7da7-000000/RvGa2m93GQNHAsTUJIPrRm2-mTA=75) Yee Lian Chew, Yoshinori Tanizawa, Yongmin Cho, Buyun Zhao, Alex J. Yu, Evan L. Ardiel, Ithai Rabinowitch, Jihong Bai, Catharine H. Rankin, Hang Lu, Isabel Beets, William R. Schafer Open Access Arousal is an important conserved behavioral state where animals show increased sensory responsiveness and locomotor hyperactivity. Chew et al. identify a neuromodulatory pathway that enables mechanosensory neurons to promote both sensory and locomotor arousal via activation of a neuroendocrine center. [Hippocampal CB1 Receptors Control Incidental Associations](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30687-1%3Fdgcid=raven_jbs_etoc_email/1/01000165f285739a-62cd7780-6d30-4aac-8ed3-164b533d7da7-000000/N2VYkNwkMNsiURgGf-nVTn7_J2E=75) Arnau Busquets-Garcia, José F. Oliveira da Cruz, Geoffrey Terral, Antonio C. Pagano Zottola, Edgar Soria-Gómez, Andrea Contini, Hugo Martin, Bastien Redon, Marjorie Varilh, Christina Ioannidou, Filippo Drago, Federico Massa, Xavier Fioramonti, Pierre Trifilieff, Guillaume Ferreira, Giovanni Marsicano Busquets-Garcia et al. suggest that cannabinoid CB1 receptors signaling in the hippocampus, a brain structure involved in memory processes, underlines the mammalian ability to associate randomly encountered stimuli, allowing future inferred memories and possibly explaining seemingly ungrounded responses toward certain cues. [Coordinated Reductions in Excitatory Input to the Nucleus Accumbens Underlie Food Consumption](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30649-4%3Fdgcid=raven_jbs_etoc_email/1/01000165f285739a-62cd7780-6d30-4aac-8ed3-164b533d7da7-000000/zQUoSKDqjELlbnRglgVR3g8dr38=75) Sean J. Reed, Christopher K. Lafferty, Jesse A. Mendoza, Angela K. Yang, Thomas J. Davidson, Logan Grosenick, Karl Deisseroth, Jonathan P. Britt Reed et al. report that opposing activity is present within each of the excitatory afferents to the nucleus accumbens during reward-seeking behavior. Synchronized reductions in excitatory input to the rostral nucleus accumbens shell correlate with and promote food consumption. [Kappa Opioid Receptor Distribution and Function in Primary Afferents](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30773-6%3Fdgcid=raven_jbs_etoc_email/1/01000165f285739a-62cd7780-6d30-4aac-8ed3-164b533d7da7-000000/hGCMrBtCK0w6JiuTX6xdAsb_qdo=75) Lindsey M. Snyder, Michael C. Chiang, Emanuel Loeza-Alcocer, Yu Omori, Junichi Hachisuka, Tayler D. Sheahan, Jenna R. Gale, Peter C. Adelman, Elizabeth I. Sypek, Stephanie A. Fulton, Robert L. Friedman, Margaret C. Wright, Melissa Giraldo Duque, Yeon Sun Lee, Zeyu Hu, Huizhen Huang, Xiaoyun Cai, Kimberly A. Meerschaert, Vidhya Nagarajan, Toshiro Hirai, Gregory Scherrer, Daniel H. Kaplan, Frank Porreca, Brian M. Davis, Michael S. Gold, H. Richard Koerber, Sarah E. Ross Snyder et al. identify primary afferents that express the kappa opioid receptor in mouse and human and show that kappa opioid receptor signaling inhibits these cells in physiological and behavioral experiments. [Correlation of Synaptic Inputs in the Visual Cortex of Awake, Behaving Mice](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30681-0%3Fdgcid=raven_jbs_etoc_email/1/01000165f285739a-62cd7780-6d30-4aac-8ed3-164b533d7da7-000000/B23e33SVprlk2e1A5ck7_cdCOo0=75) Sergio Arroyo, Corbett Bennett, Shaul Hestrin Arroyo et al. examine the correlation of subthreshold synaptic activity in superficial neurons of primary visual cortex in awake mice, providing new insights into the function of neuronal correlations and the mechanisms that generate them. [Monitoring and Updating of Action Selection for Goal-Directed Behavior through the Striatal Direct and Indirect Pathways](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30675-5%3Fdgcid=raven_jbs_etoc_email/1/01000165f285739a-62cd7780-6d30-4aac-8ed3-164b533d7da7-000000/PoPOF0LFVTBjeSTBM38TdPb83Xg=75) Satoshi Nonomura, Kayo Nishizawa, Yutaka Sakai, Yasuo Kawaguchi, Shigeki Kato, Motokazu Uchigashima, Masahiko Watanabe, Ko Yamanaka, Kazuki Enomoto, Satomi Chiken, Hiromi Sano, Shogo Soma, Junichi Yoshida, Kazuyuki Samejima, Masaaki Ogawa, Kazuto Kobayashi, Atsushi Nambu, Yoshikazu Isomura, Minoru Kimura In rats performing reward-oriented action selection, we demonstrate that striatal direct pathway neurons encode chosen action-associated reward and indirect pathway neurons encode no-reward outcomes and next selection. Activation of direct or indirect pathways biases toward repeating or switching actions, respectively. [Multi-dimensional Coding by Basolateral Amygdala Neurons](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30634-2%3Fdgcid=raven_jbs_etoc_email/1/01000165f285739a-62cd7780-6d30-4aac-8ed3-164b533d7da7-000000/yAwTGWwfx34rKHnO5LEeBtfvyaY=75) Pinelopi Kyriazi, Drew B. Headley, Denis Pare Kyriazi et al. show that most BLA neurons concurrently encode multiple task features, including the sensory properties of CSs and the behaviors they elicit. This leads to multiple task dimensions being represented at the population level. [Generative Predictive Codes by Multiplexed Hippocampal Neuronal Tuplets](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30645-7%3Fdgcid=raven_jbs_etoc_email/1/01000165f285739a-62cd7780-6d30-4aac-8ed3-164b533d7da7-000000/xmUdzS0auzbyrK4H3RZZpxzoEyc=75) Kefei Liu, Jeremie Sibille, George Dragoi Liu et al. show that hippocampal neurons are functionally organized into short tuplet (mostly triplet) motifs whose combination and recombination into extended sequences and subsequent editing result in predictive and replay codes with large capacity for rapid encoding and recall of distinct novel experiences. [Big-Loop Recurrence within the Hippocampal System Supports Integration of Information across Episodes](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30682-2%3Fdgcid=raven_jbs_etoc_email/1/01000165f285739a-62cd7780-6d30-4aac-8ed3-164b533d7da7-000000/cIOG-WYHOlbG96ovIL5HSbtUJtc=75) Raphael Koster, Martin J. Chadwick, Yi Chen, David Berron, Andrea Banino, Emrah Düzel, Demis Hassabis, Dharshan Kumaran The hippocampus is central for storing distinct episodes, while also supporting integration across related episodes. Using ultra-high-resolution fMRI, Koster et al. provide evidence for a core computational principle (big-loop recurrence) that can account for these apparently conflicting hippocampal roles. Corrections --------------------------------------------------------------- [Differential Control of Axonal and Somatic Resting Potential by Voltage-Dependent Conductances in Cortical Layer 5 Pyramidal Neurons](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30771-2%3Fdgcid=raven_jbs_etoc_email/1/01000165f285739a-62cd7780-6d30-4aac-8ed3-164b533d7da7-000000/jlpCDmsffGO5uTMLstLDdsqOqAM=75) Wenqin Hu, Bruce P. Bean [The BDNF Val66Met Prodomain Disassembles Dendritic Spines Altering Fear Extinction Circuitry and Behavior](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30770-0%3Fdgcid=raven_jbs_etoc_email/1/01000165f285739a-62cd7780-6d30-4aac-8ed3-164b533d7da7-000000/qitBYe42aa64HrcHwbOOe0akXjc=75) Joanna I. Giza, Jihye Kim, Heidi C. Meyer, Agustin Anastasia, Iva Dincheva, Crystal I. Zheng, Katherine Lopez, Henrietta Bains, Jianmin Yang, Clay Bracken, Conor Liston, Deqiang Jing, Barbara L. Hempstead, Francis S. 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