Neuron: September 5, 2018 (Volume 99, Issue 5)

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[Still time to register.](%2F%2Fwww.cell-symposia.com%2Fneurotechnologies-2018%2F/2/01000165aa751490-38b5d426-6107-4317-aa7e-fbc1935dc1b9-000000/CPqFxwayz0NKya0bDY4Fbsb5YAo=73) [Listened. Learned. Introducing Sneak Peek 2.0](%2F%2Fssrn.com%2Fcellpress%2Fsneakpeek%3Futm_campaign=STMJ_1528489500_EDITA%26utm_medium=email%26utm_source=Other%26dgcid=STMJ_1528489500_EDITA/1/01000165aa751490-38b5d426-6107-4317-aa7e-fbc1935dc1b9-000000/Qlzdm7jizR36SYVY0ZIsC43ORa8=73) Now it’s even easier to preview Cell Press papers under review. Improved search and access to abstracts without registration makes browsing content fast and seamless. DOI registration and single article links means papers posted to Sneak Peek can be cited earlier in the publication process—so authors can surface their research quickly and readers can build on their work. [Go on, satisfy your curiosity! Check out Sneak Peek 2.0 today.](%2F%2Fssrn.com%2Fcellpress%2Fsneakpeek%3Futm_campaign=STMJ_1528489500_EDITA%26utm_medium=email%26utm_source=Other%26dgcid=STMJ_1528489500_EDITA/2/01000165aa751490-38b5d426-6107-4317-aa7e-fbc1935dc1b9-000000/aUiwSK5eVVlvHDi1SqZsJlzNsiA=73) [CrossTalk Q&A with Deborah Sweet](%2F%2Fcrosstalk.cell.com%2Fblog%2Fa-qa-with-vp-of-editorial-deborah-sweet-on-leading-cell-press-forward/1/01000165aa751490-38b5d426-6107-4317-aa7e-fbc1935dc1b9-000000/IWh8FXiocMSj_VeVMoRfhq0mMAI=73 ) [In a Q&A on CrossTalk](%2F%2Fcrosstalk.cell.com%2Fblog%2Fa-qa-with-vp-of-editorial-deborah-sweet-on-leading-cell-press-forward/2/01000165aa751490-38b5d426-6107-4317-aa7e-fbc1935dc1b9-000000/O9vPzQugvSu8zS2usboXm-ie7EQ=73 ), Cell Press VP of Editorial Deborah Sweet shares what she's learned from her career as an editor, what she is already accomplishing in her new role, and the ways in which Cell Press is evolving. Featured Article --------------------------------------------------------------- [Counterfactual Reasoning Underlies the Learning of Priors in Decision Making](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30633-0/1/01000165aa751490-38b5d426-6107-4317-aa7e-fbc1935dc1b9-000000/nSziAHydFJqDENnyo2ZF96nr9X8=73) Ariel Zylberberg, Daniel M. Wolpert, Michael N. Shadlen Featured Review --------------------------------------------------------------- [Interplay between Oxytocin and Sensory Systems in the Orchestration of Socio-Emotional Behaviors](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30590-7/1/01000165aa751490-38b5d426-6107-4317-aa7e-fbc1935dc1b9-000000/StleweTzZdbRlqFvJOH2RnhW7tU=73) Valery Grinevich, Ron Stoop Online Now --------------------------------------------------------------- [Hippocampal CB1 Receptors Control Incidental Associations](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30687-1/1/01000165aa751490-38b5d426-6107-4317-aa7e-fbc1935dc1b9-000000/wJnQ0a4TuIbK4MYpwwp5xhlNLS0=73) Busquets-Garcia et al. [Reducing Astrocyte Calcium Signaling In Vivo Alters Striatal Microcircuits and Causes Repetitive Behavior](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30688-3/1/01000165aa751490-38b5d426-6107-4317-aa7e-fbc1935dc1b9-000000/PHGigFsGIlflrFWqVkWf_SRPDhE=73) Yu et al. Video Abstract --------------------------------------------------------------- %2F%2Fyoutu.be%2FEbyvDaAlKV0/1/01000165aa751490-38b5d426-6107-4317-aa7e-fbc1935dc1b9-000000/E7wd-FZvhu5Fboep9myB6ZPvM2M=73 [PhotonSABER Casts Light on Learning Mechanisms](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30632-9/1/01000165aa751490-38b5d426-6107-4317-aa7e-fbc1935dc1b9-000000/ngt_1WbhZ1nCnd3sI46RDSzvFxY=73) Long-term depression (LTD) of synaptic transmission is believed as a cellular substrate for learning and memory, but its role remains unclear in vivo. Using a new tool, PhotonSABER, [Kakegawa et al.](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30632-9/2/01000165aa751490-38b5d426-6107-4317-aa7e-fbc1935dc1b9-000000/oqfMfUid_HXLN2DzEP_aL6lqlbA=73) show that LTD at cerebellar synapses is directly responsible for motor learning in vivo. Table of Contents Previews --------------------------------------------------------------- [Gyrification Needs Correct Sodium Flux!](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30678-0%3Fdgcid=raven_jbs_etoc_email/1/01000165aa751490-38b5d426-6107-4317-aa7e-fbc1935dc1b9-000000/aVNpz7-Crkw9GdiG7GmZbIG9pGk=73) Silvia Cappello Channelopathies are disorders that affect the function of ion channels, typically resulting in epilepsy. Smith et al. (2018) discover an unusual association between SCN3A, neuronal migration, and cortical folding, outlining sodium channels as important regulators of brain development. [The Tau of Nuclear-Cytoplasmic Transport](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30731-1%3Fdgcid=raven_jbs_etoc_email/1/01000165aa751490-38b5d426-6107-4317-aa7e-fbc1935dc1b9-000000/j2V9UB4bZaxsqy2sOHLNtwzmIl0=73) Evan Lester, Roy Parker Aggregation of microtubule-associated protein tau is the hallmark of tauopathies, including Alzheimer’s disease. Eftekharzadeh et al. (2018) demonstrate that pathogenic tau alters nucleocytoplasmic transport by interacting with components of the nuclear pore complex, revealing a perturbation shared by multiple neurodegenerative diseases. [Circuits for Raiders](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30727-X%3Fdgcid=raven_jbs_etoc_email/1/01000165aa751490-38b5d426-6107-4317-aa7e-fbc1935dc1b9-000000/mY1Gjq2SCn_VDTJTo02N099mJ6Y=73) Gregorio Luis Galiñanes, Daniel Huber Heindorf et al. (2018) report that motor cortex plays a key role in behavioral tasks that rely on continuous sensory feedback. They propose a layer-based circuit that might be of particular importance when coping with unexpected perturbations in dynamic environments. [Planning Your Way: How Humans Strategically Evaluate Prospective Decisions](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30733-5%3Fdgcid=raven_jbs_etoc_email/1/01000165aa751490-38b5d426-6107-4317-aa7e-fbc1935dc1b9-000000/HgFuw67zGacdBST9ULr0IVdTi-M=73) Adrian G. Fischer We are capable of planning ahead by incorporating dynamic factors influencing future choices. In this issue of Neuron, Kolling et al. (2018) present fMRI results of a novel task that demonstrates how humans evaluate alternative environments by prospectively incorporating their characteristics over time and account for their own decision tendencies. Obituary --------------------------------------------------------------- [Wilfrid Rall (1922–2018)](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30730-X%3Fdgcid=raven_jbs_etoc_email/1/01000165aa751490-38b5d426-6107-4317-aa7e-fbc1935dc1b9-000000/QFPofkSRcAwE9Sx3pP5kIpI9nhQ=73) Idan Segev, Michael Häusser, John Rinzel, Gordon M. Shepherd Q&A --------------------------------------------------------------- [Carla Shatz](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30732-3%3Fdgcid=raven_jbs_etoc_email/1/01000165aa751490-38b5d426-6107-4317-aa7e-fbc1935dc1b9-000000/CofPdRGEdoupR3KLg6WLFPfYMrU=73) Carla J. Shatz is interested in how precise connectivity is established during brain development. In an interview with Neuron, she shares her excitement that we might someday restore plasticity to the aging or damaged brain, and the thrill of going scientifically where few have ventured before. [Mu-ming Poo](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30726-8%3Fdgcid=raven_jbs_etoc_email/1/01000165aa751490-38b5d426-6107-4317-aa7e-fbc1935dc1b9-000000/G8nIbNeQERIbw0LRtZBR2QEj0ic=73) Mu-ming Poo is currently working on higher cognitive functions and models of brain disorders in China, where he’s spearheaded the China Brain Project. In an interview with Neuron, he discusses the ethics of using non-human primates for research and enthuses about the potential for collaboration between AI and neuroscience researchers. Review --------------------------------------------------------------- [Interplay between Oxytocin and Sensory Systems in the Orchestration of Socio-Emotional Behaviors](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30590-7%3Fdgcid=raven_jbs_etoc_email/1/01000165aa751490-38b5d426-6107-4317-aa7e-fbc1935dc1b9-000000/pBIAUQpAnCwcoQ8ltDr7TSfdGpk=73) Valery Grinevich, Ron Stoop Grinevich and Stoop provide an overview of oxytocin modulation of sensory systems and conversely of sensory input modulation of oxytocin signaling in the context of socio-emotional behaviors and potential treatment of human mental diseases. Report --------------------------------------------------------------- [Sodium Channel SCN3A (NaV1.3) Regulation of Human Cerebral Cortical Folding and Oral Motor Development](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30650-0%3Fdgcid=raven_jbs_etoc_email/1/01000165aa751490-38b5d426-6107-4317-aa7e-fbc1935dc1b9-000000/vPoLYuQFBd74l3CcxlvYYug1yl0=73) Richard S. Smith, Connor J. Kenny, Vijay Ganesh, Ahram Jang, Rebeca Borges-Monroy, Jennifer N. Partlow, R. Sean Hill, Taehwan Shin, Allen Y. Chen, Ryan N. Doan, Anna-Kaisa Anttonen, Jaakko Ignatius, Livija Medne, Carsten G. Bönnemann, Jonathan L. Hecht, Oili Salonen, A. James Barkovich, Annapurna Poduri, Martina Wilke, Marie Claire Y. de Wit, Grazia M.S. Mancini, Laszlo Sztriha, Kiho Im, Dina Amrom, Eva Andermann, Ritva Paetau, Anna-Elina Lehesjoki, Christopher A. Walsh, Maria K. Lehtinen Smith et al. define a role for sodium channel SCN3A (NaV1.3) in the developing human cerebral cortex, as well as a cortical malformation that can result from NaV1.3 dysfunction. Articles --------------------------------------------------------------- [Defective Inflammatory Pathways in Never-Treated Depressed Patients Are Associated with Poor Treatment Response](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30674-3%3Fdgcid=raven_jbs_etoc_email/1/01000165aa751490-38b5d426-6107-4317-aa7e-fbc1935dc1b9-000000/7enuHxGYhdVFDiVlZ4a3MK0vZn8=73) Shariful A. Syed, Eléonore Beurel, David A. Loewenstein, Jeffrey A. Lowell, W. Edward Craighead, Boadie W. Dunlop, Helen S. Mayberg, Firdaus Dhabhar, W. Dalton Dietrich, Robert W. Keane, Juan Pablo de Rivero Vaccari, Charles B. Nemeroff Treatment-naive MDD patients have increased levels of pro- and anti-inflammatory markers, but overall the balance shifts toward immunosuppression of immune cells. Consistent with these findings, absence of response to antidepressant treatments has been associated with defective anti-inflammatory response. [Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer’s Disease](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30637-8%3Fdgcid=raven_jbs_etoc_email/1/01000165aa751490-38b5d426-6107-4317-aa7e-fbc1935dc1b9-000000/xwyeVGa3pys1yVzjwVzo--lTloA=73) Bahareh Eftekharzadeh, J. Gavin Daigle, Larisa E. Kapinos, Alyssa Coyne, Julia Schiantarelli, Yari Carlomagno, Casey Cook, Sean J. Miller, Simon Dujardin, Ana S. Amaral, Jonathan C. Grima, Rachel E. Bennett, Katharina Tepper, Michael DeTure, Charles R. Vanderburgh, Bianca T. Corjuc, Sarah L. DeVos, Jose Antonio Gonzalez, Jeannie Chew, Svetlana Vidensky, Fred H. Gage, Jerome Mertens, Juan Troncoso, Eckhard Mandelkow, Xavier Salvatella, Roderick Y.H. Lim, Leonard Petrucelli, Susanne Wegmann, Jeffrey D. Rothstein, Bradley T. Hyman Nuclear pore complexes control trafficking of proteins and RNA in and out of the nucleus. These studies now provide evidence that AD-related tau disrupts nuclear pore function in Alzheimer’s disease and that nuclear pore proteins cause tau to aggregate. [Timing Mechanisms Underlying Gate Control by Feedforward Inhibition](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30600-7%3Fdgcid=raven_jbs_etoc_email/1/01000165aa751490-38b5d426-6107-4317-aa7e-fbc1935dc1b9-000000/BtJMStKFhj45eApBDzzibJsLD1Y=73) Yan Zhang, Shenbin Liu, Yu-Qiu Zhang, Martyn Goulding, Yan-Qing Wang, Qiufu Ma Zhang et al. uncover a timing mechanism allowing monosynaptic excitation gated by disynaptic feedforward inhibition, involving glutamate receptor kinetics and dendritic electric filtering by potassium channels. [Mechanisms of Channel Block in Calcium-Permeable AMPA Receptors](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30625-1%3Fdgcid=raven_jbs_etoc_email/1/01000165aa751490-38b5d426-6107-4317-aa7e-fbc1935dc1b9-000000/ijZxknjk5qmVrMaQBq6-0ed9KnE=73) Edward C. Twomey, Maria V. Yelshanskaya, Alexander A. Vassilevski, Alexander I. Sobolevsky Calcium-permeable AMPA receptors (CP-AMPARs) are strongly implicated in neurological disorders. Twomey et al. uncover the structural bases of CP-AMPAR channel block by toxins and their synthetic analogs, providing a foundation for the design of new therapeutic agents. [Two Forms of Synaptic Depression Produced by Differential Neuromodulation of Presynaptic Calcium Channels](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30628-7%3Fdgcid=raven_jbs_etoc_email/1/01000165aa751490-38b5d426-6107-4317-aa7e-fbc1935dc1b9-000000/sjQIFfezvsW_K4BNowelY84LBbg=73) Kenneth J. Burke Jr., Caroline M. Keeshen, Kevin J. Bender Presynaptic neuromodulators like GABAB receptors impose high-pass filters on synaptic transmission, facilitating release when inputs arrive at high frequency. Burke et al. show that, unlike GABAB, dopamine suppresses glutamatergic release in prefrontal cortex independent of frequency, thus regulating synaptic gain. [Optogenetic Control of Synaptic AMPA Receptor Endocytosis Reveals Roles of LTD in Motor Learning](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30632-9%3Fdgcid=raven_jbs_etoc_email/1/01000165aa751490-38b5d426-6107-4317-aa7e-fbc1935dc1b9-000000/GC1Guwt14Qv8p_q3A_o95_MpOWk=73) Wataru Kakegawa, Akira Katoh, Sakae Narumi, Eriko Miura, Junko Motohashi, Akiyo Takahashi, Kazuhisa Kohda, Yugo Fukazawa, Michisuke Yuzaki, Shinji Matsuda Kakegawa et al. show that AMPA receptor endocytosis at parallel fiber-Purkinje cell synapses in the cerebellar flocculus plays a direct role in motor learning in vivo, using a new optogenetic tool, PhotonSABER, which enables the acute inhibition of AMPA receptor endocytosis during LTD. [Graded Control of Climbing-Fiber-Mediated Plasticity and Learning by Inhibition in the Cerebellum](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30598-1%3Fdgcid=raven_jbs_etoc_email/1/01000165aa751490-38b5d426-6107-4317-aa7e-fbc1935dc1b9-000000/LUy3cr2i8BoX2n6jT4QTugBJRr8=73) Matthew J.M. Rowan, Audrey Bonnan, Ke Zhang, Samantha B. Amat, Chikako Kikuchi, Hiroki Taniguchi, George J. Augustine, Jason M. Christie By linking inhibitory control of Purkinje cell dendritic Ca2+ signaling to alteration of plasticity and learning, Rowan et al. provide a mechanistic framework by which MLIs influence the ability of climbing fibers to instruct adaptive behavior in the cerebellum. [Transforming Sensory Cues into Aversive Emotion via Septal-Habenular Pathway](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30597-X%3Fdgcid=raven_jbs_etoc_email/1/01000165aa751490-38b5d426-6107-4317-aa7e-fbc1935dc1b9-000000/ohe0bI_04nHO3ql_qfNX-LiiTAc=73) Guang-Wei Zhang, Li Shen, Wen Zhong, Ying Xiong, Li I. Zhang, Huizhong W. Tao Zhang et al. reveal a circuit for processing innately aversive sensory signals, with glutamatergic projections from MS to LHb and POA to generate the emotional and a motional effect, respectively. This role of MS in mediating aversion is previously unrecognized. [Inhibitory Control of Prefrontal Cortex by the Claustrum](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30629-9%3Fdgcid=raven_jbs_etoc_email/1/01000165aa751490-38b5d426-6107-4317-aa7e-fbc1935dc1b9-000000/9YkYL64-hxAeUQbsXBXZa7N5CS8=73) Jesse Jackson, Mahesh M. Karnani, Boris V. Zemelman, Denis Burdakov, Albert K. Lee The claustrum provides a dense synaptic input to the cortex, but how claustrocortical projections modulate cortical activity is not known. Jackson et al. show that claustrocortical connections serve to inhibit cortical neural networks by activating specific subtypes of cortical interneurons. [Mouse Motor Cortex Coordinates the Behavioral Response to Unpredicted Sensory Feedback](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30644-5%3Fdgcid=raven_jbs_etoc_email/1/01000165aa751490-38b5d426-6107-4317-aa7e-fbc1935dc1b9-000000/5CzKudx3c-j716xVYAw4ZHXnHGw=73) Matthias Heindorf, Silvia Arber, Georg B. Keller Open Access The role of motor cortex in movement control is controversial. Heindorf et al. demonstrate that motor cortex mediates corrective behavioral responses to unexpected visual perturbations, paralleled by layer-specific cortical responses distinct from the ones during the same movement without perturbation. [The Locus Coeruleus Is a Complex and Differentiated Neuromodulatory System](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30635-4%3Fdgcid=raven_jbs_etoc_email/1/01000165aa751490-38b5d426-6107-4317-aa7e-fbc1935dc1b9-000000/TgndO8Wm7fc9352yyma6lRqHMYg=73) Nelson K. Totah, Ricardo M. Neves, Stefano Panzeri, Nikos K. Logothetis, Oxana Eschenko Totah et al. record spiking from populations of noradrenaline neurons in the brainstem nucleus, locus coeruleus, which affects brain-wide functions. Instead of en masse activity typical of global neuromodulation, these recordings reveal spatially and temporally diverse ensembles providing targeted neuromodulation. [Prospection, Perseverance, and Insight in Sequential Behavior](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30721-9%3Fdgcid=raven_jbs_etoc_email/1/01000165aa751490-38b5d426-6107-4317-aa7e-fbc1935dc1b9-000000/4NGe2Xw_iPEfwgzSSnX8bwjUjLY=73) Nils Kolling, Jacqueline Scholl, Adam Chekroud, Hailey A. Trier, Matthew F.S. Rushworth Open Access Kolling and Scholl et al. examined extended sequential decision-making problems. Participants used prospective information to inform even initial decision planning several steps ahead. Dorsal cingulate activity signaled prospective value while perigenual cingulate activity motivated decision sequence performance. [Counterfactual Reasoning Underlies the Learning of Priors in Decision Making](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30633-0%3Fdgcid=raven_jbs_etoc_email/1/01000165aa751490-38b5d426-6107-4317-aa7e-fbc1935dc1b9-000000/lrAFxCvHFeLnLH2qpUcinVDNgAI=73) Ariel Zylberberg, Daniel M. Wolpert, Michael N. Shadlen Open Access Zylberberg et al. show that human decision makers can learn environmental biases from sequences of difficult decisions, without feedback about accuracy, by calculating the belief that the decisions would have been correct in an unbiased environment—a form of counterfactual confidence. Correction --------------------------------------------------------------- [Common Variant Burden Contributes to the Familial Aggregation of Migraine in 1,589 Families](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30734-7%3Fdgcid=raven_jbs_etoc_email/1/01000165aa751490-38b5d426-6107-4317-aa7e-fbc1935dc1b9-000000/UKgSAUjooem_zhOpJhMAxYJspH8=73) Padhraig Gormley, Mitja I. Kurki, Marjo Eveliina Hiekkala, Kumar Veerapen, Paavo Häppölä, Adele A. Mitchell, Dennis Lal, Priit Palta, Ida Surakka, Mari Anneli Kaunisto, Eija Hämäläinen, Salli Vepsäläinen, Hannele Havanka, Hanna Harno, Matti Ilmavirta, Markku Nissilä, Erkki Säkö, Marja-Liisa Sumelahti, Jarmo Liukkonen, Matti Sillanpää, Liisa Metsähonkala, Seppo Koskinen, Terho Lehtimäki, Olli Raitakari, Minna Männikkö, Caroline Ran, Andrea Carmine Belin, Pekka Jousilahti, Verneri Anttila, Veikko Salomaa, Ville Artto, Markus Färkkilä 23andMe Research Team International Headache Genetics Consortium (IHGC), Heiko Runz, Mark J. 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