Neuron: July 11, 2018 (Volume 99, Issue 1)

[Cell press](%2F%2Fwww.cell.com/1/010001648a2d70dc-ef060736-a35f-4dc2-8fa3-90966cfdbd8e-000000/4E8h8tSUxYv0La82hyqpb8-t-Q8=65) [Facebook](%2F%2Ffacebook.com%2Fcellpress/1/010001648a2d70dc-ef060736-a35f-4dc2-8fa3-90966cfdbd8e-000000/igdgfEpW5C3Xoj062gekD27Rblw=65) [Twitter](%2F%2Ftwitter.com%2FNeuroCellPress/1/010001648a2d70dc-ef060736-a35f-4dc2-8fa3-90966cfdbd8e-000000/B9zIwtpO6Hh9F6m4dGMtjTPnLkc=65) [Youtube](%2F%2Fwww.youtube.com%2Fuser%2Fcellvideoabstracts/1/010001648a2d70dc-ef060736-a35f-4dc2-8fa3-90966cfdbd8e-000000/0nwuWaQVfdORFeK7XOt0gDuGT7E=65) [Google Plus](%2F%2Fplus.google.com%2F109244981532428954261%2Fposts/1/010001648a2d70dc-ef060736-a35f-4dc2-8fa3-90966cfdbd8e-000000/vFqmg2Y_SFUVls3bCtcnLI9BkYw=65) [Weibo](%2F%2Fweibo.com%2FCellPress/1/010001648a2d70dc-ef060736-a35f-4dc2-8fa3-90966cfdbd8e-000000/56ZKZgoRn4DQjpVW-NqvvdNNTSY=65) [Issue cover](%2F%2Fwww.cell.com%2Fneuron%2Fissue%3Fpii=S0896627317X00147/1/010001648a2d70dc-ef060736-a35f-4dc2-8fa3-90966cfdbd8e-000000/lu1ADCVXZGqJdWKzNtvZwNmeAm4=65) [Jul 11, 2018](%2F%2Fwww.cell.com%2Fneuron%2Fissue%3Fpii=S0896627317X00147/2/010001648a2d70dc-ef060736-a35f-4dc2-8fa3-90966cfdbd8e-000000/SdCxVXuLpr55sQB4TlSuIvROatg=65) Vol. 99, Iss. 1 [Website](%2F%2Fwww.cell.com%2Fneuron%2Fhome%3Fdgcid=raven_jbs_etoc_email/1/010001648a2d70dc-ef060736-a35f-4dc2-8fa3-90966cfdbd8e-000000/0YFCwWTgDjPfp27swbkocUkuk0Y=65) [Table of Contents](%2F%2Fwww.cell.com%2Fneuron%2Fissue%3Fpii=S0896627317X00147%26dgcid=raven_jbs_etoc_email/1/010001648a2d70dc-ef060736-a35f-4dc2-8fa3-90966cfdbd8e-000000/PnkEgEV-SqzTbj0FWh9mTU8Qacw=65) [Online Now](%2F%2Fwww.cell.com%2Fneuron%2Fnewarticles%3Fdgcid=raven_jbs_etoc_email/1/010001648a2d70dc-ef060736-a35f-4dc2-8fa3-90966cfdbd8e-000000/2c7Ru2Mu_oMSU9VQlBTC17rPFK0=65) [Archive](%2F%2Fwww.cell.com%2Fneuron%2Farchive%3Fdgcid=raven_jbs_etoc_email/1/010001648a2d70dc-ef060736-a35f-4dc2-8fa3-90966cfdbd8e-000000/Use-UTZymPISI1CBPhXiYsNllog=65) Highlights Announcements --------------------------------------------------------------- [Cell-NERF Symposium: Neurotechnologies](%2F%2Fcell-symposia.com%2Fneurotechnologies-2018%2F/1/010001648a2d70dc-ef060736-a35f-4dc2-8fa3-90966cfdbd8e-000000/bxVnqgTR7No_hBrC6Vbc4_kKFhM=65) Leuven, Belgium, Sept 30 – Oct 2, 2018 [Register early](%2F%2Fcell-symposia.com%2Fneurotechnologies-2018%2F/2/010001648a2d70dc-ef060736-a35f-4dc2-8fa3-90966cfdbd8e-000000/qpHKLHf6MzhxZRwZ7h-cDmG9rUg=65) and save €100 deadline July 20, 2018 [Cell Symposia: Metabolites as Signaling Molecules](%2F%2Fwww.cell-symposia.com%2Fmetabolites-2018%2F/1/010001648a2d70dc-ef060736-a35f-4dc2-8fa3-90966cfdbd8e-000000/y9P_AyOPhU_L80iHRdgIkYqpgdM=65) Dec 9 – 11, 2018 Seattle, WA, USA Join the program - [submit your abstract](%2F%2Fwww.cell-symposia.com%2Fmetabolites-2018%2F/2/010001648a2d70dc-ef060736-a35f-4dc2-8fa3-90966cfdbd8e-000000/IB4Wl7i2YgnxwSiJegiZVxGoeLQ=65) before deadline on July 23, 2018. [Listened. Learned. Introducing Sneak Peek 2.0](%2F%2Fssrn.com%2Fcellpress%2Fsneakpeek%3Futm_campaign=STMJ_1528489500_EDITA%26utm_medium=email%26utm_source=Other%26dgcid=STMJ_1528489500_EDITA/1/010001648a2d70dc-ef060736-a35f-4dc2-8fa3-90966cfdbd8e-000000/BZvJMdlYC7GAq4RWaSgbVQsrKXw=65) Now it’s even easier to preview Cell Press papers under review. Improved search and access to abstracts without registration makes browsing content fast and seamless. DOI registration and single article links means papers posted to Sneak Peek can be cited earlier in the publication process—so authors can surface their research quickly and readers can build on their work. Go on, satisfy your curiosity! [Check out Sneak Peek 2.0 today.](%2F%2Fssrn.com%2Fcellpress%2Fsneakpeek%3Futm_campaign=STMJ_1528489500_EDITA%26utm_medium=email%26utm_source=Other%26dgcid=STMJ_1528489500_EDITA/2/010001648a2d70dc-ef060736-a35f-4dc2-8fa3-90966cfdbd8e-000000/y9kn5syPl_glLkpihlgnASyA2xw=65) Featured Articles --------------------------------------------------------------- [Alzheimer’s Disease-Associated β-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30526-9/1/010001648a2d70dc-ef060736-a35f-4dc2-8fa3-90966cfdbd8e-000000/w4N4WxyPnhoPAPaGRi49Lv_aXGQ=65) Eimer et al. [Multiscale Analysis of Independent Alzheimer’s Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30421-5/1/010001648a2d70dc-ef060736-a35f-4dc2-8fa3-90966cfdbd8e-000000/4G7mKno3kzm2MSxqTey2w1z-8Tk=65) Readhead et al. Featured Review --------------------------------------------------------------- [Dendritic Tau in Alzheimer’s Disease](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30471-9/1/010001648a2d70dc-ef060736-a35f-4dc2-8fa3-90966cfdbd8e-000000/9lrP59qEmLlv51NqgyGGlklFzJc=65) Arne Ittner, Lars M. Ittner Online Now --------------------------------------------------------------- [OLMα2 Cells Bidirectionally Modulate Learning](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30490-2/1/010001648a2d70dc-ef060736-a35f-4dc2-8fa3-90966cfdbd8e-000000/Kvtc3FSrNncQroQUcb_o9h7aSGY=65) Siwani et al. [Luminance Changes Drive Directional Startle through a Thalamic Pathway](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30481-1/1/010001648a2d70dc-ef060736-a35f-4dc2-8fa3-90966cfdbd8e-000000/dNHn6lKYeQg1XBs017e6-MGG8Ok=65) Heap et al. Video Abstracts --------------------------------------------------------------- %2F%2Fyoutu.be%2FNoU9gGfgWRA/1/010001648a2d70dc-ef060736-a35f-4dc2-8fa3-90966cfdbd8e-000000/SwW7DToHJXl_84ARewqYrCp_4E0=65 [Role of L1 Interneurons in Sensory Map Formation](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30470-7/1/010001648a2d70dc-ef060736-a35f-4dc2-8fa3-90966cfdbd8e-000000/FrPl1aLYkf9hVi8UpHDrpbZDTYg=65) [Che et al.](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30470-7/2/010001648a2d70dc-ef060736-a35f-4dc2-8fa3-90966cfdbd8e-000000/a_qjjNv5zu7exOyoTn0A2ptifys=65) combine genetic tools and longitudinal in vivo calcium imaging in young mouse pups to show that superficial interneurons participate in a transient thalamocortical circuit. The recruitment of superficial networks is critical for the emergence of sensory maps and tactile discrimination. %2F%2Fyoutu.be%2FCp4bL1iKJlg/1/010001648a2d70dc-ef060736-a35f-4dc2-8fa3-90966cfdbd8e-000000/uSGMz883NzK4fzfCm3QgQluwmLk=65 [A Unique Ligand Limiting Neuronal Adaptations Necessary to Extinguish Fear](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30422-7/1/010001648a2d70dc-ef060736-a35f-4dc2-8fa3-90966cfdbd8e-000000/SmOyRXMLBx6VNhIwkvm5c-JzY2o=65) [Dr. Giza and co-authors](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30422-7/2/010001648a2d70dc-ef060736-a35f-4dc2-8fa3-90966cfdbd8e-000000/8gpE5WrWUIis_ZJu9e-ZcF7DFGQ=65) reveal how they arrived at the discovery that the BDNF Met prodomain is the first ligand eliminating mature spines and synapses in hippocampal neurons. They also describe that the neurons developing in the presence of the Met prodomain are unable to grow the proper connections needed to adapt and eliminate unnecessary fears. Table of Contents Previews --------------------------------------------------------------- [Axon Guidance: Gained in Translation](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30536-1%3Fdgcid=raven_jbs_etoc_email/1/010001648a2d70dc-ef060736-a35f-4dc2-8fa3-90966cfdbd8e-000000/mKlpzER9wtl6iY5zvRj6rR4F_ms=65) Frédéric Charron In this issue of Neuron, Cagnetta et al. (2018) describe a novel method to identify, in an unbiased manner, newly synthesized axonal proteins in response to axon guidance cues. They find that axons stimulated by different guidance cues (Netrin-1, BDNF, and Sema3A) show distinct and common signatures. [mTOR’ing across the Cortex by Chopping the Cilia](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30538-5%3Fdgcid=raven_jbs_etoc_email/1/010001648a2d70dc-ef060736-a35f-4dc2-8fa3-90966cfdbd8e-000000/BXuFlw9nhoQjUBfc2f434ZH1t_E=65) Alessia Di Nardo, Mustafa Sahin Somatic mutation of the MTOR gene is a genetic etiology of focal malformations of cortical development. In this issue of Neuron, Park et al. (2018) identify defective autophagy-dependent ciliogenesis/Wnt signaling as an underlying mechanism affecting neuronal migration and cortical lamination. [Parallel Processing of Negative Feedback: E Unum Pluribus](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30537-3%3Fdgcid=raven_jbs_etoc_email/1/010001648a2d70dc-ef060736-a35f-4dc2-8fa3-90966cfdbd8e-000000/MvTPEE9_3a0SSFAmOC8DvGk4VNM=65) Jen-Chun Hsiang, Daniel Kerschensteiner How do canonical computational elements interact to shape neural circuit function? In this issue of Neuron, Drinnenberg et al. (2018) show that parallel processing converts unitary negative feedback at the first synapse of the retina into diverse output signals to the brain. [Are We There Yet? Identification of Reward-Selective Cells in the Hippocampus](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30533-6%3Fdgcid=raven_jbs_etoc_email/1/010001648a2d70dc-ef060736-a35f-4dc2-8fa3-90966cfdbd8e-000000/xCsPC4jcvlaNO1pR3DV3Qf5U9H0=65) Marielena Sosa, Loren M. Frank Navigation to a previously visited reward site requires a reliable and accurate spatial memory. In this issue of Neuron, Gauthier and Tank (2018) use two-photon calcium imaging to uncover a discrete hippocampal subpopulation specialized for encoding reward location. Voices --------------------------------------------------------------- [Setting the Stage for the Next Generation of Neuroscience](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30539-7%3Fdgcid=raven_jbs_etoc_email/1/010001648a2d70dc-ef060736-a35f-4dc2-8fa3-90966cfdbd8e-000000/zcnKh1YkKdCfcUn2e93IKIGATYM=65) Neuroscientists share their vision—spanning from the nanoscale to complex social behavior—for what is needed to take on the big challenges of the field. Review --------------------------------------------------------------- [Dendritic Tau in Alzheimer’s Disease](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30471-9%3Fdgcid=raven_jbs_etoc_email/1/010001648a2d70dc-ef060736-a35f-4dc2-8fa3-90966cfdbd8e-000000/Wxaf-FXessInMjR-iuJnlJ1Z63E=65) Arne Ittner, Lars M. Ittner The microtubule-associated protein tau is critically involved in Alzheimer’s disease. Ittner and Ittner review recent advances on the localized functions of tau in dendrites and post-synapses under physiological conditions and in the context of Alzheimer’s pathogenesis. NeuroResource --------------------------------------------------------------- [Rapid Cue-Specific Remodeling of the Nascent Axonal Proteome](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30472-0%3Fdgcid=raven_jbs_etoc_email/1/010001648a2d70dc-ef060736-a35f-4dc2-8fa3-90966cfdbd8e-000000/I0PY9vYkEUmo0b_qT4UqWySKyic=65) Roberta Cagnetta, Christian K. Frese, Toshiaki Shigeoka, Jeroen Krijgsveld, Christine E. Holt Open Access Cagnetta et al. establish a highly sensitive proteomics approach to characterize the nascent proteome of a subcellular compartment (axon) on a rapid timescale (minutes). Remarkably, different extrinsic cues trigger distinct signatures of up- and downregulated nascent protein changes within 5 min. Reports --------------------------------------------------------------- [A Visual-Cue-Dependent Memory Circuit for Place Navigation](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30419-7%3Fdgcid=raven_jbs_etoc_email/1/010001648a2d70dc-ef060736-a35f-4dc2-8fa3-90966cfdbd8e-000000/BAninllU9r513YbXDPZElT1nYAE=65) Han Qin, Ling Fu, Bo Hu, Xiang Liao, Jian Lu, Wenjing He, Shanshan Liang, Kuan Zhang, Ruijie Li, Jiwei Yao, Junan Yan, Hao Chen, Hongbo Jia, Benedikt Zott, Arthur Konnerth, Xiaowei Chen Open Access Qin et al. identify a persistent-task-associated activity selectively in the medial entorhinal cortex layer II-hippocampal dentate gyrus pathway in freely moving mice after place learning. They find that this activity is required for navigation to the learned place. [Alzheimer’s Disease-Associated β-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30526-9%3Fdgcid=raven_jbs_etoc_email/1/010001648a2d70dc-ef060736-a35f-4dc2-8fa3-90966cfdbd8e-000000/jOH9SJGcQXcuDnGDEDvn4lO3zms=65) William A. Eimer, Deepak Kumar Vijaya Kumar, Nanda Kumar Navalpur Shanmugam, Alex S. Rodriguez, Teryn Mitchell, Kevin J. Washicosky, Bence György, Xandra O. Breakefield, Rudolph E. Tanzi, Robert D. Moir Eimer et al. report that Aβ traps herpes viruses in insoluble deposits called amyloid. High amyloid accumulation is known to drive Alzheimer’s disease pathology. Hence, this study suggests that active herpes infections in brain may accelerate amyloid deposition and the progression of Alzheimer’s disease. Articles --------------------------------------------------------------- [Multiscale Analysis of Independent Alzheimer’s Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30421-5%3Fdgcid=raven_jbs_etoc_email/1/010001648a2d70dc-ef060736-a35f-4dc2-8fa3-90966cfdbd8e-000000/UioO7jGYz1IuqPQyxMHs8Jzro3Y=65) Ben Readhead, Jean-Vianney Haure-Mirande, Cory C. Funk, Matthew A. Richards, Paul Shannon, Vahram Haroutunian, Mary Sano, Winnie S. Liang, Noam D. Beckmann, Nathan D. Price, Eric M. Reiman, Eric E. Schadt, Michelle E. Ehrlich, Sam Gandy, Joel T. Dudley Readhead et al. construct multiscale networks of the late-onset Alzheimer’s disease (AD)-associated virome and observe pathogenic regulation of molecular, clinical, and neuropathological networks by several common viruses, particularly human herpesvirus 6A and human herpesvirus 7. [Brain Somatic Mutations in MTOR Disrupt Neuronal Ciliogenesis, Leading to Focal Cortical Dyslamination](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30437-9%3Fdgcid=raven_jbs_etoc_email/1/010001648a2d70dc-ef060736-a35f-4dc2-8fa3-90966cfdbd8e-000000/NS8TowYzeiLBfhjh3fzCqY5QKJ4=65) Sang Min Park, Jae Seok Lim, Suresh Ramakrishina, Se Hoon Kim, Woo Kyeong Kim, Junehawk Lee, Hoon-Chul Kang, Jeremy F. Reiter, Dong Seok Kim, Hyongbum (Henry) Kim, Jeong Ho Lee Park et al. demonstrate that brain somatic mutations in MTOR result in defective neuronal ciliogenesis in FMCDs. The aberrant accumulation of OFD1 by impaired autophagy is responsible for defective ciliogenesis. Moreover, defective ciliogenesis accounts for cortical dyslamination in FMCDs by compromising Wnt signals. [Layer I Interneurons Sharpen Sensory Maps during Neonatal Development](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30470-7%3Fdgcid=raven_jbs_etoc_email/1/010001648a2d70dc-ef060736-a35f-4dc2-8fa3-90966cfdbd8e-000000/V_zDfWGlPQTNKYAWkI_YL5y0QGY=65) Alicia Che, Rachel Babij, Andrew F. Iannone, Robert N. Fetcho, Monica Ferrer, Conor Liston, Gord Fishell, Natalia V. De Marco García Che et al. combine genetic tools and longitudinal in vivo calcium imaging in young mouse pups to show that superficial interneurons participate in a transient thalamocortical circuit. Their recruitment is critical for the emergence of sensory maps and sensory discrimination. [How Diverse Retinal Functions Arise from Feedback at the First Visual Synapse](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30469-0%3Fdgcid=raven_jbs_etoc_email/1/010001648a2d70dc-ef060736-a35f-4dc2-8fa3-90966cfdbd8e-000000/MxvVdnYyxkt3lxRiETuDS4-K3PI=65) Antonia Drinnenberg, Felix Franke, Rei K. Morikawa, Josephine Jüttner, Daniel Hillier, Peter Hantz, Andreas Hierlemann, Rava Azeredo da Silveira, Botond Roska Interneurons are key actors in the input-output transformations of many brain regions. Combining experiment and theory, Drinnenberg and Franke et al. show how a single interneuron type in the retina shapes the functional diversity of the retinal output. [Internally Generated Predictions Enhance Neural and Behavioral Detection of Sensory Stimuli in an Electric Fish](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30474-4%3Fdgcid=raven_jbs_etoc_email/1/010001648a2d70dc-ef060736-a35f-4dc2-8fa3-90966cfdbd8e-000000/GCoDRPnHirI7r3SfooYezA1pJG8=65) Armen G. Enikolopov, L.F. Abbott, Nathaniel B. Sawtell Stable and accurate perception requires combining sensory input with predictions based on past experience. Using electric fish as a model system, Enikolopov et al. demonstrate improvements in neural coding and behavioral detection of external stimuli due to internally generated predictions. [Persistent Sodium Current Mediates the Steep Voltage Dependence of Spatial Coding in Hippocampal Pyramidal Neurons](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30423-9%3Fdgcid=raven_jbs_etoc_email/1/010001648a2d70dc-ef060736-a35f-4dc2-8fa3-90966cfdbd8e-000000/cUaa-hIppo5YJGcantchE6XfhCo=65) Ching-Lung Hsu, Xinyu Zhao, Aaron D. Milstein, Nelson Spruston The hippocampus encodes experience using “place cells.” Hsu et al. show that their firing is rapidly and reversibly regulated by small changes in membrane potential through persistent sodium current, providing a biophysical mechanism by which behavior can influence place cell firing. [The BDNF Val66Met Prodomain Disassembles Dendritic Spines Altering Fear Extinction Circuitry and Behavior](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30422-7%3Fdgcid=raven_jbs_etoc_email/1/010001648a2d70dc-ef060736-a35f-4dc2-8fa3-90966cfdbd8e-000000/ZjgB1k89uECmFSyd5w5m9PlHL8k=65) Joanna I. Giza, Jihye Kim, Heidi C. Meyer, Agustin Anastasia, Iva Dincheva, Crystal I. Zheng, Katherine Lopez, Henrietta Bains, Jianmin Yang, Clay Bracken, Conor Liston, Deqiang Jing, Barbara L. Hempstead, Francis S. Lee The BDNF Val66Met prodomain is associated with reduced ability to extinguish fear memories. Giza et al. show that the BDNF Met prodomain eliminates spines in vCA1 neurons projecting to the PL, diminishing their capacity to adapt during extinction. [A Dedicated Population for Reward Coding in the Hippocampus](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30476-8%3Fdgcid=raven_jbs_etoc_email/1/010001648a2d70dc-ef060736-a35f-4dc2-8fa3-90966cfdbd8e-000000/DqszIJM3q15uvQicPX_p37zg-_E=65) Jeffrey L. Gauthier, David W. Tank Gauthier and Tank use in vivo imaging to identify a small population of CA1 and subiculum neurons specialized for encoding reward location. The same cells are active near multiple reward sites in one environment and even across environments during global remapping. [A Dynamic Bayesian Observer Model Reveals Origins of Bias in Visual Path Integration](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30467-7%3Fdgcid=raven_jbs_etoc_email/1/010001648a2d70dc-ef060736-a35f-4dc2-8fa3-90966cfdbd8e-000000/N7HwUGaD4WStHzp8kNXwIjusgmY=65) Kaushik J. Lakshminarasimhan, Marina Petsalis, Hyeshin Park, Gregory C. DeAngelis, Xaq Pitkow, Dora E. Angelaki Humans are typically biased while navigating by integrating their self-motion. Using virtual reality and probabilistic modeling, Lakshminarasimhan et al. demonstrate that systematic errors in visual path integration originate from the combined influence of a slow-velocity prior and growing position uncertainty. [Enhanced Neural Processing by Covert Attention only during Microsaccades Directed toward the Attended Stimulus](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30468-9%3Fdgcid=raven_jbs_etoc_email/1/010001648a2d70dc-ef060736-a35f-4dc2-8fa3-90966cfdbd8e-000000/MNOJOT9iGfdUfR7491ik4IlC1cA=65) Eric Lowet, Bruno Gomes, Karthik Srinivasan, Huihui Zhou, Robert John Schafer, Robert Desimone Attention can be “covertly” directed without eye movements; yet, even during fixation, there are microsaccades. We found that neural activity was enhanced by attention, but only following a microsaccade toward the stimulus, revealing a major link between covert attention and the oculomotor system. [Feature-Based Visual Short-Term Memory Is Widely Distributed and Hierarchically Organized](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30424-0%3Fdgcid=raven_jbs_etoc_email/1/010001648a2d70dc-ef060736-a35f-4dc2-8fa3-90966cfdbd8e-000000/Fqub69Iqb8dBDHaQXOp45j9kjfI=65) Nicholas M. Dotson, Steven J. Hoffman, {NAME} Goodell, Charles M. Gray Dotson et al. recorded from 42 cortical areas in monkeys performing a feature-based memory task. They find that task-dependent differences in firing rates are widely distributed, while stimulus-specific changes in firing rates are more restricted and hierarchically organized. [Attractor Dynamics in Networks with Learning Rules Inferred from In Vivo Data](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30436-7%3Fdgcid=raven_jbs_etoc_email/1/010001648a2d70dc-ef060736-a35f-4dc2-8fa3-90966cfdbd8e-000000/dE3TCs_NNphHOaJ46uko8BrNZQ4=65) Ulises Pereira, Nicolas Brunel A network model with a learning rule inferred from data recorded in the primate cortex exhibits attractor dynamics with nearly optimal storage capacity. A transition to chaotic dynamics is found at strong coupling, leading to highly irregular activity but stable memory. Corrections --------------------------------------------------------------- [Parvalbumin Interneurons Modulate Striatal Output and Enhance Performance during Associative Learning](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30530-0%3Fdgcid=raven_jbs_etoc_email/1/010001648a2d70dc-ef060736-a35f-4dc2-8fa3-90966cfdbd8e-000000/yX4eBDo5udJiyhHEwCGO2R7inhE=65) Kwang Lee, Sandra M. Holley, Justin L. Shobe, Natalie C. Chong, Carlos Cepeda, Michael S. Levine, Sotiris C. Masmanidis [The Epigenetic State of PRDM16-Regulated Enhancers in Radial Glia Controls Cortical Neuron Position](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(18)30527-0%3Fdgcid=raven_jbs_etoc_email/1/010001648a2d70dc-ef060736-a35f-4dc2-8fa3-90966cfdbd8e-000000/sCn590q0lbAPbnnLJLKkGzckatE=65) José-Manuel Baizabal, Meeta Mistry, Miguel Turrero García, Nicolás Gómez, Olubusola Olukoya, Diana Tran, Matthew B. Johnson, Christopher A. Walsh, Corey C. Harwell [Update Your Profile](%2F%2Fwww.cell.com%2Faction%2FshowPreferences%3FmenuTab=Alerts%26code=cell-site/1/010001648a2d70dc-ef060736-a35f-4dc2-8fa3-90966cfdbd8e-000000/Ruo2molu1erLGN6x2jNnwRR3cjQ=65) [Terms and Conditions](%2F%2Fwww.elsevier.com%2Flegal%2Felsevier-website-terms-and-conditions/1/010001648a2d70dc-ef060736-a35f-4dc2-8fa3-90966cfdbd8e-000000/M8zL40TvZMPiXBdquo1kbM6sJkc=65) [Privacy Policy](%2F%2Fwww.elsevier.com%2Flegal%2Fprivacy-policy/1/010001648a2d70dc-ef060736-a35f-4dc2-8fa3-90966cfdbd8e-000000/KIYsTZ8RkvS8MfThukUCzg3eeCw=65) [Follow this link to unsubscribe.](%2F%2Fwww.cell.com%2Falerts%2Funsubscribe%3FsubscriptionID=c1bedb93-d933-486c-b094-8eaf812d893b%26hash=eeca2f294f987df4d4ae56abbd699bf6e686193b/1/010001648a2d70dc-ef060736-a35f-4dc2-8fa3-90966cfdbd8e-000000/bCtxh6NrrLsIYkhts5tGrqwBGN4=65) This email has been sent from Cell Press, a division of Elsevier Inc., 50 Hampshire Street, 5th Floor, Cambridge, MA 02139, USA. You are receiving this email because you signed up for email alerts for new issues of this journal. For all inquiries, problems or suggestions regarding this service, please contact [our support group.](%2F%2Fservice.elsevier.com%2Fapp%2Foverview%2Fcell-press%2F/1/010001648a2d70dc-ef060736-a35f-4dc2-8fa3-90966cfdbd8e-000000/Y67Zw8SOgUc3KLZ1KlV7DNQR9Q4=65) Copyright © 2018 Elsevier Inc. All rights reserved. Subscription ID: c1bedb93-d933-486c-b094-8eaf812d893b Webuser ID: a55d53f7ab892786bd7dece67e5041dc06f264ea Results Event ID: f1945dba-139c-42f3-bd90-35b05b159399