Neuron: September 4, 2024 (Volume 112, Issue 17)

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Featured articles --------------------------------------------------------------- [Mentoring to propagate racial inclusivity in neuroscience](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00577-4/1/01000191bdabbf2b-0ae41c0b-0d7d-48a5-9671-1d5995c33d68-000000/JdMKEaANYJHnAOAoR9goDkZeTkgvoWo9BP4SAyPFoHQ=369) Rodriguez-Romaguera et al. [Principles of cortical areas and their implications for neuroimaging](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00355-6/1/01000191bdabbf2b-0ae41c0b-0d7d-48a5-9671-1d5995c33d68-000000/Uftrz0C8wV_VKj2nyw0P4rD6MiVyaEtBPz_PnJIW4A4=369) Petersen et al. [Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of a-synuclein inclusions](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00409-4/1/01000191bdabbf2b-0ae41c0b-0d7d-48a5-9671-1d5995c33d68-000000/DC5yqFkpHv2VFUjb-6UZkoVMxtVncazlfNc_P4JvUys=369) Lam et al. [Microglia are not necessary for maintenance of blood-brain barrier properties in health, but PLX5622 alters brain endothelial cholesterol metabolism](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00537-3/1/01000191bdabbf2b-0ae41c0b-0d7d-48a5-9671-1d5995c33d68-000000/uWJAv09TSv82RJbNKhLwNjey4jBJNELNkTno8Ew3s3g=369) Profaci et al. Online now --------------------------------------------------------------- [Network-wide risk convergence in gene co-expression identifies reproducible genetic hubs of schizophrenia risk](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00575-0/1/01000191bdabbf2b-0ae41c0b-0d7d-48a5-9671-1d5995c33d68-000000/1a0PbG7KB7tAsCJHL69-wLa1sIcS0BEUmUgXhpobuuc=369) Borcuk et al. [Neuronal enhancers fine-tune adaptive circuit plasticity](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00574-9/1/01000191bdabbf2b-0ae41c0b-0d7d-48a5-9671-1d5995c33d68-000000/dDtM-R1hSTDOGSUdojO2vOe1MIEo0A2kmxR3_SXtVmI=369) Griffith et al. [Single-cell dissection of the human blood-brain barrier and glioma blood-tumor barrier](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00571-3/1/01000191bdabbf2b-0ae41c0b-0d7d-48a5-9671-1d5995c33d68-000000/CoNxHyixxznfCA7eBV92pavF74ORtfWo30I6KSTqMmU=369) Xie et al. [Disruption of nuclear speckle integrity dysregulates RNA splicing in C9ORF72-FTD/ALS](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00570-1/1/01000191bdabbf2b-0ae41c0b-0d7d-48a5-9671-1d5995c33d68-000000/SwiOBClcn2l2vGOpGr0HwuRfkFHuJAassLgff2MzmDE=369) Wu et al. Table of Contents Previews --------------------------------------------------------------- [Plaudits for logits in sensory neuroscience](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00580-4%3Fdgcid=raven_jbs_etoc_email/1/01000191bdabbf2b-0ae41c0b-0d7d-48a5-9671-1d5995c33d68-000000/VgGD0DYTd5oX6JQdGOS-eDa9pI1GRfB28FtIddT9sas=369) Joshua J.H. Ryu, Justin L. Gardner A workhorse tool of economic decision-making has long sought to get inside people’s heads through careful examination of their choices. In this issue of Neuron, Carandini flips the script, showing how it can model how the brain makes sensory choices. [Impacts beyond the brain: Unraveling molecular mechanisms linking psychiatric, metabolic, and inflammatory conditions](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00573-7%3Fdgcid=raven_jbs_etoc_email/1/01000191bdabbf2b-0ae41c0b-0d7d-48a5-9671-1d5995c33d68-000000/p4BSrbThF4dYNIM4rA05etJXCO7RvBcAJYeMXlIF2_k=369) Nathaniel Napoli, Quenten Schwarz By establishing semaphorin 6D expression in the amygdala as a central coordinator of brain, metabolic, and immunologic function, the Neuron publication by Nakanishi et al. provides new insight to how primary brain deficiency impacts physiological systems beyond the brain. [Keep calm and carry H3K27me1 off](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00536-1%3Fdgcid=raven_jbs_etoc_email/1/01000191bdabbf2b-0ae41c0b-0d7d-48a5-9671-1d5995c33d68-000000/aJAqaTzFvJc40rSAUWrspEbyd3ayf8Goonu2ZvS0PSc=369) Rafael Alcalá-Vida, Angel Barco In this issue of Neuron, Torres-Berrío et al. show that stress-susceptible mice exhibit elevated H3K27me1 levels in nucleus accumbens neurons due to the action of the SUZ12 VEFS domain, strengthening the link between specific epigenetic changes and long-lasting stress-induced social, emotional, and cognitive alterations. NeuroView --------------------------------------------------------------- [Mentoring to propagate racial inclusivity in neuroscience](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00577-4%3Fdgcid=raven_jbs_etoc_email/1/01000191bdabbf2b-0ae41c0b-0d7d-48a5-9671-1d5995c33d68-000000/zqvY7aHE8nR24V6KHwKabfCndasaPfbpYTKoNa-mdIk=369) Jose Rodriguez-Romaguera, Gregory J. Quirk Mentoring the next generation of neuroscientists from historically excluded backgrounds brings several challenges. Successful mentor-mentee relationships are critical for addressing these challenges. Rodriguez-Romaguera and Quirk reflect on lessons learned from their cross-racial mentor-mentee relationship that could apply to many mentors. Perspective --------------------------------------------------------------- [Principles of cortical areas and their implications for neuroimaging](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00355-6%3Fdgcid=raven_jbs_etoc_email/1/01000191bdabbf2b-0ae41c0b-0d7d-48a5-9671-1d5995c33d68-000000/mPsbLIQqg6uES6B6dfdnmNwHTAd_h1i7W40qWM-3Rlg=369) Steven E. Petersen, Benjamin A. Seitzman, Steven M. Nelson, Gagan S. Wig, Evan M. Gordon Open Access Petersen et al. review fundamental principles of the areal organization of the cerebral cortex. They discuss the definition, formation, interactions, and functions of cortical areas, and they identify ways in which the principles of arealization should guide human neuroimaging research. Viewpoint --------------------------------------------------------------- [Sensory choices as logistic classification](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00451-3%3Fdgcid=raven_jbs_etoc_email/1/01000191bdabbf2b-0ae41c0b-0d7d-48a5-9671-1d5995c33d68-000000/bE6TBKvEVoNFzty02Kc3HJ2TKfL4lOe1MuRRHA7j1dk=369) Matteo Carandini Open Access Logistic classification describes human and animal choices based on factors such as expected value, sensory inputs of multiple modalities, prior probabilities, overall motivation, recent actions, and brain manipulations. It bridges two established models: signal detection theory and drift diffusion. The brain uses it widely, even when it is not optimal. NeuroResources --------------------------------------------------------------- [SHIELD: Skull-shaped hemispheric implants enabling large-scale electrophysiology datasets in the mouse brain](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00450-1%3Fdgcid=raven_jbs_etoc_email/1/01000191bdabbf2b-0ae41c0b-0d7d-48a5-9671-1d5995c33d68-000000/698_JT0cUYVAGokAlF2q4rgufetislWb-2OhSv3RSSA=369) Corbett Bennett, Ben Ouellette, Tamina K. Ramirez, Alex Cahoon, Hannah Cabasco, Yoni Browning, Anna Lakunina, Galen F. Lynch, Ethan G. McBride, Hannah Belski, Ryan Gillis, Conor Grasso, Robert Howard, Tye Johnson, Henry Loeffler, Heston Smith, David Sullivan, Allison Williford, Shiella Caldejon, Severine Durand, Samuel Gale, Alan Guthrie, Vivian Ha, Warren Han, Ben Hardcastle, Chris Mochizuki, Arjun Sridhar, Lucas Suarez, Jackie Swapp, Joshua Wilkes, Joshua H. Siegle, Colin Farrell, Peter A. Groblewski, Shawn R. Olsen High-density electrode arrays such as Neuropixels are transformative for neuroscience research, but optimized surgical and experimental methodologies are necessary to fully harness the power of these devices. Here, Bennett et al. describe customizable cranial implants and workflows for multi-probe recordings of neuronal spiking across the mouse brain. [Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of α-synuclein inclusions](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00409-4%3Fdgcid=raven_jbs_etoc_email/1/01000191bdabbf2b-0ae41c0b-0d7d-48a5-9671-1d5995c33d68-000000/kTomvaKArIgWU1PPA2FNP2-WYXwNQBa7FXVGPIWRxMI=369) Isabel Lam, Alain Ndayisaba, Amanda J. Lewis, YuHong Fu, Giselle T. Sagredo, Anastasia Kuzkina, Ludovica Zaccagnini, Meral Celikag, Jackson Sandoe, Ricardo L. Sanz, Aazam Vahdatshoar, Timothy D. Martin, Nader Morshed, Toru Ichihashi, Arati Tripathi, Nagendran Ramalingam, Charlotte Oettgen-Suazo, Theresa Bartels, Manel Boussouf, Max Schäbinger, Erinc Hallacli, Xin Jiang, Amrita Verma, Challana Tea, Zichen Wang, Hiroyuki Hakozaki, Xiao Yu, Kelly Hyles, Chansaem Park, Xinyuan Wang, Thorold W. Theunissen, Haoyi Wang, Rudolf Jaenisch, Susan Lindquist, Beth Stevens, Nadia Stefanova, Gregor Wenning, Wilma D.J. van de Berg, Kelvin C. Luk, Rosario Sanchez-Pernaute, Juan Carlos Gómez-Esteban, Daniel Felsky, Yasujiro Kiyota, Nidhi Sahni, S. Stephen Yi, Chee Yeun Chung, Henning Stahlberg, Isidro Ferrer, Johannes Schöneberg, Stephen J. Elledge, Ulf Dettmer, Glenda M. Halliday, Tim Bartels, Vikram Khurana Open Access Intracellular proteinaceous inclusions in neurodegeneration are heterogeneous. Lam, Ndayisaba, et al. developed an iPSC toolbox to rapidly induce CNS cells with inclusions. α-Synuclein “inclusionopathy” models, with gene- and protein-interaction screens, uncover novel inclusion subtypes, their molecular markers, and their effects on neuronal survival. Biological relevance was established in Parkinson’s postmortem brains. Report --------------------------------------------------------------- [Microglia are not necessary for maintenance of blood-brain barrier properties in health, but PLX5622 alters brain endothelial cholesterol metabolism](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00537-3%3Fdgcid=raven_jbs_etoc_email/1/01000191bdabbf2b-0ae41c0b-0d7d-48a5-9671-1d5995c33d68-000000/NFH-i-tcoj1nxE6fUcbxDZxDQeuhKtQHzo--lhzX02c=369) Caterina P. Profaci, Sean S. Harvey, Kaja Bajc, Tony Z. Zhang, Danielle A. Jeffrey, Alexander Z. Zhang, Kelsey M. Nemec, Hayk Davtyan, Carleigh A. O’Brien, Gabriel L. McKinsey, Aaron Longworth, Timothy P. McMullen, Joia K. Capocchi, Jessica G. Gonzalez, Devon A. Lawson, Thomas D. Arnold, Dimitrios Davalos, Mathew Blurton-Jones, Fabrice Dabertrand, F. Chris Bennett, Richard Daneman Open Access Profaci et al. show that microglia are not required for BBB maintenance in young, healthy adult mice. Surprisingly, PLX5622, a drug widely used for microglial depletion, alters CNS endothelial cholesterol independently from microglial depletion. These findings augment the understanding of microglial-endothelial interaction and illuminate an off-target effect of a common research tool. Articles --------------------------------------------------------------- [Sequence variations and accessory proteins adapt TMC functions to distinct sensory modalities](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00448-3%3Fdgcid=raven_jbs_etoc_email/1/01000191bdabbf2b-0ae41c0b-0d7d-48a5-9671-1d5995c33d68-000000/SToS2NvQgmmrhP_8Ottx3h1yervHewQ5Jzt23kzeQU0=369) Qiang Jiang, Wenjuan Zou, Shitian Li, Xufeng Qiu, Linhui Zhu, Lijun Kang, Ulrich Müller Jiang et al. demonstrate that combinations of different accessory proteins tune nematode TMC-1 to different sensory functions. In addition, distinct structural domains of nematode TMC-1 mediate mechanosensation and alkaline sensing. These domains are segregated between mammalian mTMC1 and mTMC3, and mTMC1 supports mechanosensation in nematodes, while mTMC3 supports alkaline sensing. [Embryonically active piriform cortex neurons promote intracortical recurrent connectivity during development](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00414-8%3Fdgcid=raven_jbs_etoc_email/1/01000191bdabbf2b-0ae41c0b-0d7d-48a5-9671-1d5995c33d68-000000/zSKcGeHspoo_om0BpAhBq7tJ39IxD4MhQsZsDJ-O56Q=369) David C. Wang, Fernando Santos-Valencia, Jun H. Song, Kevin M. Franks, Liqun Luo Open Access Using TRAP to perform a brain-wide screen for embryonically active neurons, Wang et al. identify and demonstrate the transient developmental role of activity in a hub-like neuronal population in promoting recurrent connectivity in the piriform cortex. These findings suggest a mechanism of activity-dependent maturation of intracortical circuits. [Semaphorin 6D tunes amygdalar circuits for emotional, metabolic, and inflammatory outputs](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00452-5%3Fdgcid=raven_jbs_etoc_email/1/01000191bdabbf2b-0ae41c0b-0d7d-48a5-9671-1d5995c33d68-000000/ZaZPz4jtmMOFrWThmndDHegjwSnf8dYkyQKxqQiAWRM=369) Yoshimitsu Nakanishi, Mayuko Izumi, Hiroaki Matsushita, Yoshihisa Koyama, Diego Diez, Hyota Takamatsu, Shohei Koyama, Masayuki Nishide, Maiko Naito, Yumiko Mizuno, Yuta Yamaguchi, Tomoki Mae, Yu Noda, Kamon Nakaya, Satoshi Nojima, Fuminori Sugihara, Daisuke Okuzaki, Masahito Ikawa, Shoichi Shimada, Sujin Kang, Atsushi Kumanogoh Open Access Nakanishi et al. reveal that semaphorin 6D signaling maintains synaptic homeostasis and regulates GABAergic transmission in the amygdala, thereby coordinating emotional, metabolic, and inflammatory responses under stress conditions. [Mono-methylation of lysine 27 at histone 3 confers lifelong susceptibility to stress](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00413-6%3Fdgcid=raven_jbs_etoc_email/1/01000191bdabbf2b-0ae41c0b-0d7d-48a5-9671-1d5995c33d68-000000/9nE9CyXcVquFGyzXMdrYl5-2yonygcFCstPze1IsAgs=369) Angélica Torres-Berrío, Molly Estill, Vishwendra Patel, Aarthi Ramakrishnan, Hope Kronman, Angélica Minier-Toribio, Orna Issler, Caleb J. Browne, Eric M. Parise, Yentl Y. van der Zee, Deena M. Walker, Freddyson J. Martínez-Rivera, Casey K. Lardner, Romain Durand-de Cuttoli, Scott J. Russo, Li Shen, Simone Sidoli, Eric J. Nestler Torres-Berrío et al. establish a novel function of a form of histone methylation—H3K27me1—in the nucleus accumbens, part of the brain’s reward circuitry, and demonstrate its role as a “chromatin scar” that mediates lifelong behavioral, physiological, and transcriptional signatures of stress susceptibility in mice. 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