Neuron: July 17, 2024 (Volume 112, Issue 14)

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[Celebrating science that inspires new directions](%2F%2Fwww.cell.com%2Fcell-press-50/1/01000190c159471a-3262fe45-244f-4512-8e66-d4f2f09fd51c-000000/COkzX0Tqpecp5xUHCY89PnmeaScpe9o0KMpXFlsi7Sk=362) See what we have planned for our 50th anniversary year Featured articles --------------------------------------------------------------- [Cryo-EM structures of pathogenic fibrils and their impact on neurodegenerative disease research](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00359-3/1/01000190c159471a-3262fe45-244f-4512-8e66-d4f2f09fd51c-000000/BiMXP2n6_cDyy6f97No6M6c0SIAo2UIZYB8X-KKew24=362) Todd et al. [Mixed selectivity: Cellular computations for complexity](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00278-2/1/01000190c159471a-3262fe45-244f-4512-8e66-d4f2f09fd51c-000000/_pn_DKo_Jm3E8ISS4OFgmE8uJoZafk-dT_bAck7N2mE=362) Tye et al. [A pupillary contrast response in mice and humans: Neural mechanisms and visual functions](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00273-3/1/01000190c159471a-3262fe45-244f-4512-8e66-d4f2f09fd51c-000000/n-H3RRTjHUCQrFMlmX1kmcmlVjYffRDF-fd5_nfk0O4=362) Fitzpatrick et al. [A unifying framework for functional organization in early and higher ventral visual cortex](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00279-4/1/01000190c159471a-3262fe45-244f-4512-8e66-d4f2f09fd51c-000000/u0vooo6MxNBQRc9u_S5leY7_3oyo-KBSSt0CmH4dLro=362) Margalit et al. Online now --------------------------------------------------------------- [Mature enteric neurons have the capacity to reinnervate the intestine with glial cells as their guide](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00453-7/1/01000190c159471a-3262fe45-244f-4512-8e66-d4f2f09fd51c-000000/lMHJijadWo8niV9D2IbJqqItKWQZ2Oz1rgJSqzCXrN0=362) Stavely et al. [Astrocytes modulate brain phosphate homeostasis via polarized distribution of phosphate uptake transporter PiT2 and exporter XPR1](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00455-0/1/01000190c159471a-3262fe45-244f-4512-8e66-d4f2f09fd51c-000000/XbBikXhs6l1f3wGFRPg3VSz0xud87YJbgYhiCL37Py4=362) Cheng et al. [A single-cell atlas deconstructs heterogeneity across multiple models in murine traumatic brain injury and identifies novel cell-specific targets](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00456-2/1/01000190c159471a-3262fe45-244f-4512-8e66-d4f2f09fd51c-000000/77EhS5NqDXBPT17FiqW_z7X16j-okPW-GxfrTCzUuJs=362) Jha et al. [A hypothalamic-amygdala circuit underlying sexually dimorphic aggression](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00457-4/1/01000190c159471a-3262fe45-244f-4512-8e66-d4f2f09fd51c-000000/O1ZORzTejLoKxxfyQaWRGOtS0LDrkt9s8ttLrDeJx4s=362) Zhu et al. Table of Contents Previews --------------------------------------------------------------- [Thalamic cells and pathway for social memory processing and storage](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00458-6%3Fdgcid=raven_jbs_etoc_email/1/01000190c159471a-3262fe45-244f-4512-8e66-d4f2f09fd51c-000000/mQjkV9-slTlA_7ncoNj1lrFUIiJt9LgBFUfRGbu-3dk=362) Wen-Jun Gao In this issue of Neuron, Wang et al. demonstrate that parvalbumin interneurons in the sensory thalamic reticular nucleus are necessary and sufficient for regulating social memory in mice, identify a novel cortico-reticular thalamic-parafascicular pathway for social cognition, and highlight an essential role of GABAergic inhibitory neurons in social memory engrams. [Pupil constriction by contrast for contrast](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00415-X%3Fdgcid=raven_jbs_etoc_email/1/01000190c159471a-3262fe45-244f-4512-8e66-d4f2f09fd51c-000000/LY0E3j-F5JZOE6Am6cFrLA2pvM-k6NJwLhD6ONrbHSI=362) Michael Tri H. Do The pupil is the eye’s adjustable aperture. Fitzpatrick et al. find that visual contrast constricts the pupil, increasing contrast. This process improves behavioral performance. Its retinal origin has unorthodox elements, like interneurons that make connections in unusual locales and photoreceptive ganglion cells. [Dissecting attention: Rate modulation vs. phase locking](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00489-6%3Fdgcid=raven_jbs_etoc_email/1/01000190c159471a-3262fe45-244f-4512-8e66-d4f2f09fd51c-000000/o-cy4WrxMWCVy9PbkbLTcxJl3vaClfQDiPnriWoStJ4=362) Moein Esghaei, Julio Martinez-Trujillo, Stefan Treue In this issue of Neuron, Spyropoulos et al. report direct top-down modulation of neuronal firing rates underlying selective visual attentional modulation. Meeting report --------------------------------------------------------------- [Internal world models in humans, animals, and AI](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00454-9%3Fdgcid=raven_jbs_etoc_email/1/01000190c159471a-3262fe45-244f-4512-8e66-d4f2f09fd51c-000000/ioAGtpbupwAB0VNAy3jLUxvAEVHU8Mvf591hy2hiBwg=362) Ilka Diester, Marlene Bartos, Joschka Bödecker, Adam Kortylewski, Christian Leibold, Johannes Letzkus, Mathew M. Nour, Monika Schönauer, Andrew Straw, Abhinav Valada, Andreas Vlachos, Thomas Brox How do brains—biological or artificial—respond and adapt to an ever-changing environment? In a recent meeting, experts from various fields of neuroscience and artificial intelligence met to discuss internal world models in brains and machines, arguing for an interdisciplinary approach to gain deeper insights into the underlying mechanisms. Review --------------------------------------------------------------- [Cryo-EM structures of pathogenic fibrils and their impact on neurodegenerative disease research](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00359-3%3Fdgcid=raven_jbs_etoc_email/1/01000190c159471a-3262fe45-244f-4512-8e66-d4f2f09fd51c-000000/q_xrQzPvwUOT8p0SEvwW7Z7rgQMZbmW3gnWqtgkOlGo=362) Tiffany W. Todd, Naeyma N. Islam, Casey N. Cook, Thomas R. Caulfield, Leonard Petrucelli Neurodegenerative diseases are often characterized by the deposition of amyloidogenic proteins in the brain. Todd et al. review the structures of disease-associated fibrils as determined by cryoelectron microscopy and discuss how these structures provide mechanistic and translational insight. Perspective --------------------------------------------------------------- [Mixed selectivity: Cellular computations for complexity](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00278-2%3Fdgcid=raven_jbs_etoc_email/1/01000190c159471a-3262fe45-244f-4512-8e66-d4f2f09fd51c-000000/jAb4fPoIAvllxmxRygF3aC1qYTlqdqZwQs8GKKh8XHU=362) Kay M. Tye, Earl K. Miller, Felix H. Taschbach, Marcus K. Benna, Mattia Rigotti, Stefano Fusi Open Access Neurons capable of mixed selectivity enhance the brain’s computational capabilities by responding to various inputs in complex ways, beyond simple combinations. Here, we describe possible neural mechanisms underlying mixed selectivity and discuss how they contribute to the brain’s dynamic flexibility in processing diverse information with efficiency. Report --------------------------------------------------------------- [Threat-dependent scaling of prelimbic dynamics to enhance fear representation](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00317-9%3Fdgcid=raven_jbs_etoc_email/1/01000190c159471a-3262fe45-244f-4512-8e66-d4f2f09fd51c-000000/Vr8rZt1l8sbxbv9i_hnANXufAPznJmWkqm-M3a-O7CU=362) José Patricio Casanova, Clément Pouget, Nadja Treiber, Ishaant Agarwal, Mark Allen Brimble, Gisella Vetere Through a comparative analysis across brain regions and risk situations, Casanova et al. demonstrate the distinctive role of the prelimbic cortex (PL) in fear-related behavior representation: the PL promptly detects threat stimuli and adjusts its neuronal configuration accordingly, resulting in a change in freezing representation, which is necessary for memory-associated fear expression. Articles --------------------------------------------------------------- [Compensatory enhancement of input maintains aversive dopaminergic reinforcement in hungry Drosophila](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00325-8%3Fdgcid=raven_jbs_etoc_email/1/01000190c159471a-3262fe45-244f-4512-8e66-d4f2f09fd51c-000000/9wZ6x4K4uPXW7yX2lvGmDUod_BiaiGfNwccixUAp-fg=362) Eleonora Meschi, Lucille Duquenoy, Nils Otto, Georgia Dempsey, Scott Waddell Open Access Meschi et al. discover a detailed neuronal mechanism through which a hormonal signal of nutrient deficit modulates aversive learning. Hormone-responsive neurons in the base of the fly brain enhance the gain of ascending input pathways that transduce punishing shock and bitter taste to dopaminergic neurons that write aversive memories. [Specialized connectivity of molecular layer interneuron subtypes leads to disinhibition and synchronous inhibition of cerebellar Purkinje cells](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00248-4%3Fdgcid=raven_jbs_etoc_email/1/01000190c159471a-3262fe45-244f-4512-8e66-d4f2f09fd51c-000000/UZ2i0apGum1aj6ST4sG7S3jt7Tt8U2lvT_I76G2UaY0=362) Elizabeth P. Lackey, Luis Moreira, Aliya Norton, Marie E. Hemelt, Tomas Osorno, Tri M. Nguyen, Evan Z. Macosko, Wei-Chung Allen Lee, Court A. Hull, Wade G. Regehr Lackey et al. show that molecular layer interneurons comprise two subtypes with distinct connectivity that are suited to serve different roles. MLI1s are electrically coupled, tend to fire synchronously, and preferentially inhibit Purkinje cells, whereas MLI2s are not electrically coupled, primarily inhibit MLI1s, and disinhibit Purkinje cells. [Long-wavelength traveling waves of vasomotion modulate the perfusion of cortex](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00324-6%3Fdgcid=raven_jbs_etoc_email/1/01000190c159471a-3262fe45-244f-4512-8e66-d4f2f09fd51c-000000/T3g_xzu0gGXUl5j1X3yXKQ9bR0AaB_McAAgcoGrHOK0=362) Thomas Broggini, Jacob Duckworth, Xiang Ji, Rui Liu, Xinyue Xia, Philipp Mächler, Iftach Shaked, Leon Paul Munting, Satish Iyengar, Michael Kotlikoff, Susanne J. van Veluw, Massimo Vergassola, Gal Mishne, David Kleinfeld Broggini, Duckworth, et al. assessed the physiological impact and spatiotemporal dynamics of the ∼0.1 Hz oscillations in the diameter of neocortical arterioles in the awake mouse. They found that the oscillations within penetrating arterioles, which source blood from pial arterioles to the capillary bed, profoundly modulate resting-state perfusion throughout neocortex. [The thalamic reticular nucleus orchestrates social memory](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00274-5%3Fdgcid=raven_jbs_etoc_email/1/01000190c159471a-3262fe45-244f-4512-8e66-d4f2f09fd51c-000000/MKrGqmEN_0C6E7kNwfsVZYGcn9uJKnxBsDnNhrQCXGM=362) Feidi Wang, Huan Sun, Mingyue Chen, Ban Feng, Yu Lu, Mi Lyu, Dongqi Cui, Yifang Zhai, Ying Zhang, Yaomin Zhu, Changhe Wang, Haitao Wu, Xiancang Ma, Feng Zhu, Qiang Wang, Yan Li Open Access The establishment and refinement of higher brain functions during evolution require various core brain regions to accurately and efficiently control specific types of memories. Wang et al. demonstrate that the sensory reticular thalamus specifically mediates social memory, making it an ideal target for treating social amnesia. [A latent pool of neurons silenced by sensory-evoked inhibition can be recruited to enhance perception](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00276-9%3Fdgcid=raven_jbs_etoc_email/1/01000190c159471a-3262fe45-244f-4512-8e66-d4f2f09fd51c-000000/Z75MIv8yqJZz-X_e9yrKlANcl1MPwleaD_2pd8hfFs4=362) Oliver M. Gauld, Adam M. Packer, Lloyd E. Russell, Henry W.P. Dalgleish, Maya Iuga, Francisco Sacadura, Arnd Roth, Beverley A. Clark, Michael Häusser Open Access Gauld et al. use all-optical interrogation to probe sparse coding in the barrel cortex. They find that targeted photostimulation of task-silent neurons evokes perceptual choice bias and that these neurons are selectively suppressed by inhibition during whisker processing. Their findings show that silent neurons can be recruited to enhance behavior. [A pupillary contrast response in mice and humans: Neural mechanisms and visual functions](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00273-3%3Fdgcid=raven_jbs_etoc_email/1/01000190c159471a-3262fe45-244f-4512-8e66-d4f2f09fd51c-000000/jroX8G5wA9BQ50EoJkwoJG5-sbvN7oTWO4-pPL9HP2k=362) Michael J. Fitzpatrick, Jenna Krizan, Jen-Chun Hsiang, Ning Shen, Daniel Kerschensteiner The pupil is well known to constrict in response to increases in luminance. Here, Fitzpatrick et al. show that temporal contrast also drives pupil construction via a cell-type-specific retinal circuit in mice and humans. The pupillary contrast response enhances high spatial frequency contrast in the retinal image and improves visual acuity. [Distinct feedforward and feedback pathways for cell-type specific attention effects](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00281-2%3Fdgcid=raven_jbs_etoc_email/1/01000190c159471a-3262fe45-244f-4512-8e66-d4f2f09fd51c-000000/4N3KcLUuLxX-1RMry3qifsEWnv6CVK7P1jq1IGTLP38=362) Georgios Spyropoulos, Marius Schneider, Jochem van Kempen, Marc Alwin Gieselmann, Alexander Thiele, Martin Vinck Open Access Spyropoulos et al. show that attention modulates V1-V4 firing rates and gamma phase-locking via distinct feedforward and feedback pathways. Firing-rate modulation is strongest and earliest in Layers II/III of V4, consistent with feedback. Gamma phase-locking to feedforward V1 gamma is confined to fast-spiking interneurons in Layer IV of V4. [A unifying framework for functional organization in early and higher ventral visual cortex](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00279-4%3Fdgcid=raven_jbs_etoc_email/1/01000190c159471a-3262fe45-244f-4512-8e66-d4f2f09fd51c-000000/yu0iAlvWSHyZdJP9R_FmggMcHlHyTA6Djmk0IDqAMIw=362) Eshed Margalit, Hyodong Lee, Dawn Finzi, James J. DiCarlo, Kalanit Grill-Spector, Daniel L.K. Yamins Margalit et al. develop a topographic artificial neural network that predicts both functional responses and spatial organization of multiple cortical areas of the primate visual system. In turn, the model minimizes between-area wiring length and produces more brain-like responses to visual stimuli than spatially unconstrained alternative models. Editorial note --------------------------------------------------------------- [Core transcription programs controlling injury-induced neurodegeneration of retinal ganglion cells](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00445-8%3Fdgcid=raven_jbs_etoc_email/1/01000190c159471a-3262fe45-244f-4512-8e66-d4f2f09fd51c-000000/5VoHaxpnmXhGLMOstsnL4TXDE2nrfad9Oe23YwpOCjQ=362) Feng Tian, Yuyan Cheng, Songlin Zhou, Qianbin Wang, Aboozar Monavarfeshani, Kun Gao, Weiqian Jiang, Riki Kawaguchi, Qing Wang, Mingjun Tang, Ryan Donahue, Huyan Meng, Yu Zhang, Anne Jacobi, Wenjun Yan, Jiani Yin, Xinyi Cai, Zhiyun Yang, Shane Hegarty, Joanna Stanicka, Phillip Dmitriev, Daniel Taub, Junjie Zhu, Clifford J. Woolf, Joshua R. Sanes, Daniel H. Geschwind, Zhigang He Correction --------------------------------------------------------------- [Core transcription programs controlling injury-induced neurodegeneration of retinal ganglion cells](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00444-6%3Fdgcid=raven_jbs_etoc_email/1/01000190c159471a-3262fe45-244f-4512-8e66-d4f2f09fd51c-000000/hKcdxTtXxEcaMU0m3LbZ6XIzAb16WbRTqsuh7Sns-eU=362) Feng Tian, Yuyan Cheng, Songlin Zhou, Qianbin Wang, Aboozar Monavarfeshani, Kun Gao, Weiqian Jiang, Riki Kawaguchi, Qing Wang, Mingjun Tang, Ryan Donahue, Huyan Meng, Yu Zhang, Anne Jacobi, Wenjun Yan, Jiani Yin, Xinyi Cai, Zhiyun Yang, Shane Hegarty, Joanna Stanicka, Phillip Dmitriev, Daniel Taub, Junjie Zhu, Clifford J. Woolf, Joshua R. Sanes, Daniel H. 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