Neuron: May 1, 2024 (Volume 112, Issue 9)

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[Keystone Symposia: Neuroimmune interactions-Nervous system and immune cell heterogeneity in health and disease](%2F%2Fhubs.la%2FQ026NNyX0/1/0100018f34dd12cd-09b84c0b-24d6-4bda-91fa-e106650cad0b-000000/zpw2Kx85O0mevayOsHMUlESYPHmoJBuOgCHUxGT3E7I=351) Join our editors at this meeting on June 3-6, 2024 | Santa Fe, USA [Call for papers: Joint special issue on brain-body interactions](%2F%2Fwww.cell.com%2Fcp%2Fspecial-issues%2Fcall-for-papers%2Fbrain-body-interactions%3Futm_campaign=STMJ_1712679220_CALLP_OA%26utm_medium=WEB%26utm_source=WEB%26dgcid=STMJ_1712679220_CALLP_OA/1/0100018f34dd12cd-09b84c0b-24d6-4bda-91fa-e106650cad0b-000000/zMwb2LSXle0wgRo2mBfbfql4AFufFSkseKzVbcd5x9M=351) We are interested in studies at the intersection of neuroscience and broader biological systems [Celebrating science that inspires new directions](%2F%2Fwww.cell.com%2Fcell-press-50/1/0100018f34dd12cd-09b84c0b-24d6-4bda-91fa-e106650cad0b-000000/KT4jdavI3S8OtA4rfTajDto2pSJ2jvEv86egNQh3_3A=351) See what we have planned for our 50th anniversary year Featured articles --------------------------------------------------------------- [Speak up & reach out: In defense of biomedical research](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00163-6/1/0100018f34dd12cd-09b84c0b-24d6-4bda-91fa-e106650cad0b-000000/-usYeajj3kbVJf9jbU48nPrT3xB0GP_Wl2IGy7uv2y4=351) Mesler et al. [Cell-type-specific expression of tRNAs in the brain regulates cellular homeostasis](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00054-0/1/0100018f34dd12cd-09b84c0b-24d6-4bda-91fa-e106650cad0b-000000/nK8HH3WJYc5kKq9P5ss3vS13TK5k_wn9LMtaeluFu_8=351) Kapur et al. [Impaired cerebellar plasticity hypersensitizes sensory reflexes in SCN2A-associated ASD](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00055-2/1/0100018f34dd12cd-09b84c0b-24d6-4bda-91fa-e106650cad0b-000000/5Ea0DEKPe6bmgdgjM_MD1al2J_T1EdQOKHs_1n2UxeI=351) Wang et al. [Sexually dimorphic control of affective state processing and empathic behaviors](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00085-0/1/0100018f34dd12cd-09b84c0b-24d6-4bda-91fa-e106650cad0b-000000/GsnU-1n2esY1_veIWHL45vJ2U8JjWr3im9a0k2147tw=351) Fang et al. Online now --------------------------------------------------------------- [A systems biology-based identification and in vivo functional screening of Alzheimer's disease risk genes reveal modulators of memory function](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00247-2/1/0100018f34dd12cd-09b84c0b-24d6-4bda-91fa-e106650cad0b-000000/inph1LSK7Z7sm-fRhur9XTQf_8ioJXZtlFVeqgNBrWU=351) Hudgins et al. [Specialized connectivity of molecular layer interneuron subtypes leads to disinhibition and synchronous inhibition of cerebellar Purkinje cells](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00248-4/1/0100018f34dd12cd-09b84c0b-24d6-4bda-91fa-e106650cad0b-000000/BHUxMhZrJWhqvnLI7g24sc2lDAAmi9TsDZIC04zljS4=351) Lackey et al. [Hypothalamic neuronal activation in non-human primates drives naturalistic goal-directed eating behavior](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00236-8/1/0100018f34dd12cd-09b84c0b-24d6-4bda-91fa-e106650cad0b-000000/P_34lKaYW4Hm-g6-zmvc4oEzuDQuN_LF0wV1ylyeYSE=351) Ha et al. [Growth hormone promotes myelin repair after chronic hypoxia via triggering pericyte-dependent angiogenesis](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00233-2/1/0100018f34dd12cd-09b84c0b-24d6-4bda-91fa-e106650cad0b-000000/CFUIFqmF6Z3QaEcENr4R7MjEcCAVbNuXGnm63G0A2tI=351) Ren et al. Table of Contents Previews --------------------------------------------------------------- [Keep calm and make neurons: The effects of glucocorticoids on human cortical neurogenesis](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00242-3%3Fdgcid=raven_jbs_etoc_email/1/0100018f34dd12cd-09b84c0b-24d6-4bda-91fa-e106650cad0b-000000/Jql7dRTHOqKlIleloJTbdQ48UiYknWhREcY-v5NhJ14=351) Virginia Fernández, Víctor Borrell Maternal well-being is important for the development of the fetus, with a key influence on its nervous system. In this issue of Neuron, Krontira et al. implicate glucocorticoids, the stress hormones, in the regulation of neural stem cell identity and proliferation, with long-lasting consequences on brain architecture and educational attainment. [More than meets the eye: A conserved sensorimotor reflex helps unravel the circuit mechanisms of ASD](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00241-1%3Fdgcid=raven_jbs_etoc_email/1/0100018f34dd12cd-09b84c0b-24d6-4bda-91fa-e106650cad0b-000000/VTUNTns_1pFHbLhnvnRis76dz26jkvhLG1RbvnePrpA=351) Romana J. Hyde, Stephanie Rudolph Animal models are instrumental to understanding the mechanisms underlying autism spectrum disorder, yet translating human behavioral phenotypes remains challenging. Wang et al. leverage a conserved sensorimotor reflex to elucidate synaptic deficits in S cn2a haploinsufficiency and pilot novel rescue strategies. [Collaterals and stroke reperfusion: Too few leads to too much](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00202-2%3Fdgcid=raven_jbs_etoc_email/1/0100018f34dd12cd-09b84c0b-24d6-4bda-91fa-e106650cad0b-000000/KIu4tZeRXQ8M-6M8LR4I4AaT7OiK5IAYDOpVQp72IpM=351) Patrick L. Reeson, Craig E. Brown Adequate reperfusion after ischemic stroke is a major determinant of functional outcome yet remains unpredictable and insufficient for most survivors. In this issue of Neuron, Binder et al. identify leptomeningeal collaterals (LMCs) in mice and human patients as a key factor in regulating reperfusion and hemorrhagic transformation following stroke. Spotlights --------------------------------------------------------------- [Hide-and-sick: How bacteria manipulate a neural circuit that makes you sick](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00243-5%3Fdgcid=raven_jbs_etoc_email/1/0100018f34dd12cd-09b84c0b-24d6-4bda-91fa-e106650cad0b-000000/F_tqoEdk3m0niUZ8_YuP2tT_xcp6dVEQgE_37rpif-s=351) Felipe A. Pinho-Ribeiro Infections frequently cause behavioral changes, known as sickness behavior. In a recent study, Yipp and collaborators discovered a sensory circuit that is activated by a bacterial lipopolysaccharide during lung infection and drives sickness behaviors independent of inflammation. Biofilm-producing bacteria, however, avoid activating this lung-brain circuit, resulting in infection without sickness behavior. [Modeling proprioception with task-driven neural network models](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00199-5%3Fdgcid=raven_jbs_etoc_email/1/0100018f34dd12cd-09b84c0b-24d6-4bda-91fa-e106650cad0b-000000/z5TQ9kv73233NCZqyP6TUwPYtFxgMkDJsXDJHi6-wr8=351) Hansjörg Scherberger In a recent issue of Cell, Vargas and colleagues demonstrate that task-driven neural network models are superior at predicting proprioceptive activity in the primate cuneate nucleus and sensorimotor cortex compared with other models. This provides valuable insights for better understanding the proprioceptive pathway. Obituary --------------------------------------------------------------- [Vivien Chevaleyre (1973–2024)](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00237-X%3Fdgcid=raven_jbs_etoc_email/1/0100018f34dd12cd-09b84c0b-24d6-4bda-91fa-e106650cad0b-000000/w-rKFY0I4cz8iHaLqRKj3ub7NfEkQQNn7fz0YEdofLs=351) Pablo E. Castillo, Michel G. Desarménien, Steven A. Siegelbaum NeuroViews --------------------------------------------------------------- [Speak up & reach out: In defense of biomedical research](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00163-6%3Fdgcid=raven_jbs_etoc_email/1/0100018f34dd12cd-09b84c0b-24d6-4bda-91fa-e106650cad0b-000000/bNU-KWMgeJ0FA1iLymmL5B62ve-nOTT-IVZKyoMNero=351) Degan Mesler, Vicki Campbell Scientists face challenges in communicating about their careers in biomedical research to the public, despite the importance of doing so. Here, we discuss tools and resources for outreach, such as posters, videos, and presentations that can be leveraged by scientists to help educate communities about the pivotal role of animals in medical progress. [Building a science of human pleasure, meaning making, and flourishing](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00200-9%3Fdgcid=raven_jbs_etoc_email/1/0100018f34dd12cd-09b84c0b-24d6-4bda-91fa-e106650cad0b-000000/6kL2gwggkZYmRDt8tJiwAKHk_0_0AQ4fZa0QYZphGFM=351) Morten L. Kringelbach, Peter Vuust, Gustavo Deco “Supporting human flourishing” is a goal of governments and societies, yet the construct may appear hard to define. We discuss the emerging science of pleasure and flourishing, insights into the brain mechanisms of meaning making and thriving, and the potential for interdisciplinary studies to advance this promising scientific field. NeuroResource --------------------------------------------------------------- [Cell-type-specific expression of tRNAs in the brain regulates cellular homeostasis](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00054-0%3Fdgcid=raven_jbs_etoc_email/1/0100018f34dd12cd-09b84c0b-24d6-4bda-91fa-e106650cad0b-000000/ImYoaxV4HL2HkYTSqvipbAKCcXxpzeBElKA01mM27A0=351) Mridu Kapur, Michael J. Molumby, Carlos Guzman, Sven Heinz, Susan L. Ackerman Open Access Kapur et al. develop a conditional epitope-tagged Pol III mouse, allowing them to profile tRNA expression in individual nervous system cell populations in vivo. Their results highlight the heterogeneity of tRNA gene expression across the nervous system and provide a platform to investigate tRNA biology in the brain. Report --------------------------------------------------------------- [Transient cAMP production drives rapid and sustained spiking in brainstem parabrachial neurons to suppress feeding](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00086-2%3Fdgcid=raven_jbs_etoc_email/1/0100018f34dd12cd-09b84c0b-24d6-4bda-91fa-e106650cad0b-000000/fAnH0fLzzMI_Djp3FHlt-syv_2XWMkaiE1_egqIDZyA=351) Jonnathan Singh Alvarado, Andrew Lutas, Joseph C. Madara, Jeremiah Isaac, Caroline Lommer, Crystian Massengill, Mark L. Andermann Singh Alvarado, Lutas, and colleagues use optical tools to demonstrate that persistent cAMP signaling directly couples to neuronal activity in the parabrachial nucleus to drive sustained suppression of feeding. The results suggest that cAMP produced by transient GPCR activation can extend the timescale of neuronal activity from seconds to minutes. Articles --------------------------------------------------------------- [Human cortical neurogenesis is altered via glucocorticoid-mediated regulation of ZBTB16 expression](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00089-8%3Fdgcid=raven_jbs_etoc_email/1/0100018f34dd12cd-09b84c0b-24d6-4bda-91fa-e106650cad0b-000000/gAFDRDI1sPeieQ-rS5Y5wrYIQ84nG98UY81ASE1aXZ4=351) Anthi C. Krontira, Cristiana Cruceanu, Leander Dony, Christina Kyrousi, Marie-Helen Link, Nils Rek, Dorothee Pöhlchen, Catarina Raimundo, Signe Penner-Goeke, Alicia Schowe, Darina Czamara, Marius Lahti-Pulkkinen, Sara Sammallahti, Elina Wolford, Kati Heinonen, Simone Roeh, Vincenza Sportelli, Barbara Wölfel, Maik Ködel, Susann Sauer, Monika Rex-Haffner, Katri Räikkönen, Marta Labeur, Silvia Cappello, Elisabeth B. Binder Open Access Krontira et al. study the effects of glucocorticoids on neurogenesis in human cerebral organoids and mice. They find that glucocorticoids, via ZBTB16, increase PAX6+EOMES+ basal progenitors, a cell type enriched in species with a gyrified brain, and upper-layer neurons. This is associated with beneficial postnatal outcomes such as enhanced cognitive performance. [Impaired cerebellar plasticity hypersensitizes sensory reflexes in SCN2A-associated ASD](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00055-2%3Fdgcid=raven_jbs_etoc_email/1/0100018f34dd12cd-09b84c0b-24d6-4bda-91fa-e106650cad0b-000000/TlOpugt3AKMsThOBeMdNyFZK23U6RqGi5emjjbqzzhA=351) Chenyu Wang, Kimberly D. Derderian, Elizabeth Hamada, Xujia Zhou, Andrew D. Nelson, Henry Kyoung, Nadav Ahituv, Guy Bouvier, Kevin J. Bender Impaired function in the sodium channel gene SCN2A is a major risk factor for autism spectrum disorder. Here, Wang and colleagues show that heterozygous loss of SCN2A in the cerebellum alters reflexive eye movements in both mouse and man and that a translatable gene therapy rescues such movements in mouse. [Leptomeningeal collaterals regulate reperfusion in ischemic stroke and rescue the brain from futile recanalization](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00057-6%3Fdgcid=raven_jbs_etoc_email/1/0100018f34dd12cd-09b84c0b-24d6-4bda-91fa-e106650cad0b-000000/rDqak31r9GMXKYPzBLbEdXfAh8AZXQRBJXWSoSAkgno=351) Nadine Felizitas Binder, Mohamad El Amki, Chaim Glück, William Middleham, Anna Maria Reuss, Adrien Bertolo, Patrick Thurner, Thomas Deffieux, Chryso Lambride, Robert Epp, Hannah-Lea Handelsmann, Philipp Baumgartner, Cyrille Orset, Philipp Bethge, Zsolt Kulcsar, Adriano Aguzzi, Mickael Tanter, Franca Schmid, Denis Vivien, Matthias Tasso Wyss, Andreas Luft, Michael Weller, Bruno Weber, Susanne Wegener Open Access Futile recanalization is a serious problem for stroke treatments. Binder and El Amki et al. demonstrate that leptomeningeal collaterals (LMCs) regulate reperfusion after stroke. Mice with poor LMCs developed rapid, uncontrolled hyperperfusion. In stroke patients, they found a similar deleterious reperfusion. Collateral function should be target of novel stroke treatments. [Phasic/tonic glial GABA differentially transduce for olfactory adaptation and neuronal aging](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00090-4%3Fdgcid=raven_jbs_etoc_email/1/0100018f34dd12cd-09b84c0b-24d6-4bda-91fa-e106650cad0b-000000/n9oPu160MFfbFr7RmujcDQtQkpJLNSOJOv7r-W-Bbz0=351) Hankui Cheng, Du Chen, Xiao Li, Umar Al-Sheikh, Duo Duan, Yuedan Fan, Linhui Zhu, Wanxin Zeng, Zhitao Hu, Xiajing Tong, Guohua Zhao, Yongming Zhang, Wenjuan Zou, Shumin Duan, Lijun Kang Cheng et al. report two modes, phasic and tonic, of GABA transductions that alternatively regulate short-term sensory adaptation and long-term neuronal aging in a Caenorhabditis elegans glia-neuron circuit. They propose that targeting glia-neuronal GABAergic transductions could serve as a lifelong strategy for promoting healthy aging and preserving neuronal stability. [Excitability mediates allocation of pre-configured ensembles to a hippocampal engram supporting contextual conditioned threat in mice](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00091-6%3Fdgcid=raven_jbs_etoc_email/1/0100018f34dd12cd-09b84c0b-24d6-4bda-91fa-e106650cad0b-000000/-sTYTrJByqVAqn3UvUI0UOEktCKptFIB_wb5G2S_kGY=351) Andrew J. Mocle, Adam I. Ramsaran, Alexander D. Jacob, Asim J. Rashid, Alessandro Luchetti, Lina M. Tran, Blake A. Richards, Paul W. Frankland, Sheena A. Josselyn Neurons are allocated to an engram ensemble during an event. Mocle et al. found that engram neurons showed endogenously elevated activity hours before an event, but pre-existing functional connectivity days before an event, suggesting that small sub-ensembles of active neurons are allocated as groups and that their functional connectivity is modified by learning. [Sexually dimorphic control of affective state processing and empathic behaviors](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00085-0%3Fdgcid=raven_jbs_etoc_email/1/0100018f34dd12cd-09b84c0b-24d6-4bda-91fa-e106650cad0b-000000/CwcMJ-_2qCe4M_LRTxefjf_OuCl6WosxxdO5p3ad14M=351) Shunchang Fang, Zhengyi Luo, Zicheng Wei, Yuxin Qin, Jieyan Zheng, Hongyang Zhang, Jianhua Jin, Jiali Li, Chenjian Miao, Shana Yang, Yonglin Li, Zirui Liang, Xiao-Dan Yu, Xiao Min Zhang, Wei Xiong, Hongying Zhu, Wen-Biao Gan, Lianyan Huang, Boxing Li Fang et al. discovered that male and female mice display different empathic behaviors in response to others’ pain. Specifically, males engage in self-grooming, whereas females demonstrate social approaching. Processing information about others’ pain involves distinct neural circuits for each sex. Importantly, these circuits inherently differ in gene expression patterns. 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