Neuron: March 20, 2024 (Volume 112, Issue 6)

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[Cell Symposia: Multifaceted mitochondria](%2F%2Fwww.cell-symposia.com%2Fmitochondria-2024%2Findex.html/1/0100018e5c86ee99-42ca8e49-18ea-4141-b710-ccacb815be12-000000/k6Ykp7ZekbNOkWIsvXeenMOiylnRzgMRjEy8fyhN2KM=345) October 27–29, 2024 | Sitges, Spain. [iScience: i stands for interdisciplinary](%2F%2Fwww.cell.com%2Fiscience%2Fhome/1/0100018e5c86ee99-42ca8e49-18ea-4141-b710-ccacb815be12-000000/g17Ay0E3BcNAAjwgNB_NhD80ymn_gJESrx1XBGyveHA=345) Explore life science research that inspires new thinking. [Cell Symposia: Functional RNAs](%2F%2Fcell-symposia.com%2Frnas-2024%2Findex.html/1/0100018e5c86ee99-42ca8e49-18ea-4141-b710-ccacb815be12-000000/pD2fGwQTHkCRlTIAqw0mTmTX0QzRSPs_2MRdT6in6GI=345) October 20–22, 2024 | Beijing, China. Featured articles --------------------------------------------------------------- [Q&A: Joseph E. LeDoux](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00087-4/1/0100018e5c86ee99-42ca8e49-18ea-4141-b710-ccacb815be12-000000/FrrfD3mS9xblgSVstk9A7NagEIA2KUCKdyA28iEH4D0=345) Joseph E. LeDoux [Neuronal ensembles: Building blocks of neural circuits](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00967-4/1/0100018e5c86ee99-42ca8e49-18ea-4141-b710-ccacb815be12-000000/v46FJue_Sm12xg3gumqeMBX7pRtrbyoVXu1g3oIBU-0=345) Yuste et al. [Sympathetic nerve-enteroendocrine L cell communication modulates GLP-1 release, brain glucose utilization, and cognitive function](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00971-6/1/0100018e5c86ee99-42ca8e49-18ea-4141-b710-ccacb815be12-000000/CoOjCEtg1VMrpFF8esdVju64jMNA3ym7KPtQevP9fsM=345) Ren et al. [Phosphorylation of pyruvate dehydrogenase inversely associates with neuronal activity](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00974-1/1/0100018e5c86ee99-42ca8e49-18ea-4141-b710-ccacb815be12-000000/g5xa3D4yKQbQM75x5qGvNPOuUhDTE2IeZ1LaBIQ7GRk=345) Yang et al. Online now --------------------------------------------------------------- [P-tau217 correlates with neurodegeneration in Alzheimer's disease, and targeting p-tau217 with immunotherapy ameliorates murine tauopathy](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00127-2/1/0100018e5c86ee99-42ca8e49-18ea-4141-b710-ccacb815be12-000000/73yPLm4TEJjPiqBq0UyjQfNjhxvEbstIkdcQFBKQovI=345) Zhang et al. [Simple spike patterns and synaptic mechanisms encoding sensory and motor signals in Purkinje cells and the cerebellar nuclei](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00124-7/1/0100018e5c86ee99-42ca8e49-18ea-4141-b710-ccacb815be12-000000/wSZJGn0WHHG1PJFc3Knjc6uabTEg5DXJzkJtC-G-TBE=345) Brown et al. [TRPV1 analgesics disturb core body temperature via a biased allosteric mechanism involving conformations distinct from that for nociception](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00126-0/1/0100018e5c86ee99-42ca8e49-18ea-4141-b710-ccacb815be12-000000/lbiriouyXGpLypsgntH4OQepi0dZkD6mYq4u1vsAayw=345) Huang et al. [Glial KCNQ K+ channels control neuronal output by regulating GABA release from glia in C. elegans](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00123-5/1/0100018e5c86ee99-42ca8e49-18ea-4141-b710-ccacb815be12-000000/u1OnZWZJyTpbhWcZ5DrKDHb7srqA8ijuHQ3dgfS7VW4=345) Graziano et al. Table of Contents Previews --------------------------------------------------------------- [A sympathetic brake on gut GLP-1 release](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00125-9%3Fdgcid=raven_jbs_etoc_email/1/0100018e5c86ee99-42ca8e49-18ea-4141-b710-ccacb815be12-000000/BE-PX6C76-gwg_K4LfHpA0vlHEhBwxvSspJaqVxZfYk=345) Antonio J. López-Gambero, Victor Jouque, Daniela Cota The brain-gut neurocircuitry is proving to be finely involved in a wide range of physiological functions. In this issue of Neuron, Ren et al. show that adrenergic signaling suppresses postprandial glucagon-like peptide 1 (GLP-1) secretion. This, in turn, raises circulating glucose levels and impairs brain glucose uptake and cognitive function. [Mirrored might: A vision for inhibition](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00128-4%3Fdgcid=raven_jbs_etoc_email/1/0100018e5c86ee99-42ca8e49-18ea-4141-b710-ccacb815be12-000000/UQ39dRe-wKKfKvLy-DErqBRIoF6hoFk3KgVrxcXjdZ4=345) Laura A. Koek, Benjamin Scholl In this issue of Neuron, Znamenskiy et al.1 unveil functional connection specificity between PV+ inhibitory interneurons and excitatory pyramidal neurons in mouse visual cortex, providing a circuit mechanism for stable amplification of cortical subpopulations. Q&A --------------------------------------------------------------- [Joseph E. LeDoux](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00087-4%3Fdgcid=raven_jbs_etoc_email/1/0100018e5c86ee99-42ca8e49-18ea-4141-b710-ccacb815be12-000000/orehx2qaCrfhgcHkIp-8SSZIrO8zFcE24tKkYQ9C48M=345) Joseph E. LeDoux In an interview with Neuron, Joseph LeDoux outlines his early work on consciousness in split-brain patients, his transition into studying emotional behavior in rodents, and his continued exploration of consciousness in books and other writings. He describes how his research fused with his interest in music, which he pursued though his band, The Amygdaloids, and their unique genre, “heavy mental.” Reviews --------------------------------------------------------------- [Neuronal ensembles: Building blocks of neural circuits](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00967-4%3Fdgcid=raven_jbs_etoc_email/1/0100018e5c86ee99-42ca8e49-18ea-4141-b710-ccacb815be12-000000/qJGlO-bWzH-U5xveTP6i1IzeocCYzbTBfosPhcyYV_w=345) Rafael Yuste, Rosa Cossart, Emre Yaksi [The mediodorsal thalamus in executive control](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00002-3%3Fdgcid=raven_jbs_etoc_email/1/0100018e5c86ee99-42ca8e49-18ea-4141-b710-ccacb815be12-000000/wEfwqVWDiOL7H87fxlsVKZqSZuRVYP-_diqv4sYWnQ0=345) Mathieu Wolff, Michael M. Halassa The review by Wolff and Halassa discusses the role of the mediodorsal (MD) thalamus in executive control. By integrating anatomical, physiological, functional, and computational studies, the authors provide a novel framework on MD function that is of basic and translational relevance. NeuroResource --------------------------------------------------------------- [Targeted micro-fiber arrays for measuring and manipulating localized multi-scale neural dynamics over large, deep brain volumes during behavior](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00970-4%3Fdgcid=raven_jbs_etoc_email/1/0100018e5c86ee99-42ca8e49-18ea-4141-b710-ccacb815be12-000000/_vs3on-vQ3H2C5VBU-9YpKxeGhHCkxHDjY7VIhqSR7U=345) Mai-Anh T. Vu, Eleanor H. Brown, Michelle J. Wen, Christian A. Noggle, Zicheng Zhang, Kevin J. Monk, Safa Bouabid, Lydia Mroz, Benjamin M. Graham, Yizhou Zhuo, Yulong Li, Timothy M. Otchy, Lin Tian, Ian G. Davison, David A. Boas, Mark W. Howe Open Access Vu et al. present a customizable approach using small-diameter optical fibers that enables dense measurements and targeted manipulations of distributed neural activity over large 3D volumes at a spatial resolution and coverage previously inaccessible. They reveal modality-specific spatiotemporal patterns of striatum-wide dopamine release in response to sensory stimuli and precise mapping of a specific behavior onto striatal location. Articles --------------------------------------------------------------- [Selective vulnerability of layer 5a corticostriatal neurons in Huntington’s disease](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00968-6%3Fdgcid=raven_jbs_etoc_email/1/0100018e5c86ee99-42ca8e49-18ea-4141-b710-ccacb815be12-000000/nERKmpogYyNKySKoW3wQMnDvY4RTMIPUV1UK13ngWeI=345) Christina Pressl, Kert Mätlik, Laura Kus, Paul Darnell, Ji-Dung Luo, Matthew R. Paul, Alison R. Weiss, William Liguore, Thomas S. Carroll, David A. Davis, Jodi McBride, Nathaniel Heintz Open Access Vulnerable cell types in the cerebral cortex in Huntington’s disease have not been delineated completely. Pressl et al. employed sFANS and snRNA-seq to reveal that L5a corticostriatal pyramidal cells are lost early in HD progression. Molecular profiling data implicate somatic CAG expansion and altered synaptic function in HD pathogenesis. [Mapping of multiple neurotransmitter receptor subtypes and distinct protein complexes to the connectome](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00973-X%3Fdgcid=raven_jbs_etoc_email/1/0100018e5c86ee99-42ca8e49-18ea-4141-b710-ccacb815be12-000000/LxiHvObEVcU1_i56E6hNF8f4TIXm8u04K1kgRjm7qu4=345) Piero Sanfilippo, Alexander J. Kim, Anuradha Bhukel, Juyoun Yoo, Pegah S. Mirshahidi, Vijaya Pandey, Harry Bevir, Ashley Yuen, Parmis S. Mirshahidi, Peiyi Guo, Hong-Sheng Li, James A. Wohlschlegel, Yoshinori Aso, S. Lawrence Zipursky Open Access Sanfilippo et al. conditionally tag neurotransmitter receptor subunits using CRISPR-based modification of endogenous loci, expansion light-sheet microscopy, immunopurification of associated proteins, and EM connectomics to map the diversity of synapses in the Drosophila brain. These studies reveal the complex molecular cartography of dendrites at the level of singly identified neuron types. [Phosphorylation of pyruvate dehydrogenase inversely associates with neuronal activity](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00974-1%3Fdgcid=raven_jbs_etoc_email/1/0100018e5c86ee99-42ca8e49-18ea-4141-b710-ccacb815be12-000000/ssaf5asuQXiTkZ9iDftYNDfG9Am8UQv6vJzdTnQ630g=345) Dong Yang, Yu Wang, Tianbo Qi, Xi Zhang, Leyao Shen, Jingrui Ma, Zhengyuan Pang, Neeraj K. Lal, Daniel B. McClatchy, Saba Heydari Seradj, Verina H. Leung, Kristina Wang, Yi Xie, Filip S. Polli, Anton Maximov, Oscar Christian Gonzalez, Luis de Lecea, Hollis T. Cline, Vineet Augustine, John R. Yates III, Li Ye Open Access Yang et al. applied an in vitro optogenetics-based proteomic screening platform to identify that the phosphorylation of pyruvate dehydrogenase (pPDH) inversely correlates with neuronal activity both in vitro and in vivo. pPDH can serve as a trackable endogenous inverse activity marker (IAM) for post hoc identification of inhibited neurons. [Sympathetic nerve-enteroendocrine L cell communication modulates GLP-1 release, brain glucose utilization, and cognitive function](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00971-6%3Fdgcid=raven_jbs_etoc_email/1/0100018e5c86ee99-42ca8e49-18ea-4141-b710-ccacb815be12-000000/vDWZVPMYMoG5knzfoe9KSSZCLMo00wkyv6q5huuwpcM=345) Wenran Ren, Jianhui Chen, Wenjing Wang, Qingqing Li, Xia Yin, Guanglei Zhuang, Hong Zhou, Wenwen Zeng Ren et al. characterize a neuro-enteroendocrine cell unit operating at the brain-gut neuronal axis, which restrains GLP-1 release upon glucose ingestion and compromises brain function by reducing glucose utilization in the brain. [Functional specificity of recurrent inhibition in visual cortex](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00972-8%3Fdgcid=raven_jbs_etoc_email/1/0100018e5c86ee99-42ca8e49-18ea-4141-b710-ccacb815be12-000000/KQPdAAoE9r9pvYruvgHKBUeHKUy8jZb2A4cN2VF-Xuk=345) Petr Znamenskiy, Mean-Hwan Kim, Dylan R. Muir, M. Florencia Iacaruso, Sonja B. Hofer, Thomas D. Mrsic-Flogel Open Access Znamenskiy et al. reveal unexpected precision of synaptic strength of parvalbumin-positive inhibitory neurons in the mouse visual cortex. By measuring their visual responses and synaptic connectivity, they show that PV+ cells preferentially inhibit those pyramidal cells that provide them with strong excitation and have similar patterns of responses in vivo. [Glutamate inputs send prediction error of reward, but not negative value of aversive stimuli, to dopamine neurons](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00979-0%3Fdgcid=raven_jbs_etoc_email/1/0100018e5c86ee99-42ca8e49-18ea-4141-b710-ccacb815be12-000000/cJqvftfrHixgr0yYVs84cVFCQVUFuzkxUx2sFFrHDzE=345) Ryunosuke Amo, Naoshige Uchida, Mitsuko Watabe-Uchida Open Access Dopamine neurons receive glutamate and GABA and send reward and punishment information to downstream areas. Amo et al. recorded glutamate inputs to dopamine neurons with a glutamate sensor. Glutamate inputs convey reward prediction error, but not punishment information, to dopamine neurons, suggesting a division of labor between glutamate and GABA inputs. [A septal-ventral tegmental area circuit drives exploratory behavior](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00975-3%3Fdgcid=raven_jbs_etoc_email/1/0100018e5c86ee99-42ca8e49-18ea-4141-b710-ccacb815be12-000000/B8sIhm2VviSVANCQWjFqDc_OIeayX0w5cc3mYbsoHUc=345) Petra Mocellin, Oliver Barnstedt, Kevin Luxem, Hiroshi Kaneko, Silvia Vieweg, Julia U. Henschke, Dennis Dalügge, Falko Fuhrmann, Anna Karpova, Janelle M.P. Pakan, Michael R. Kreutz, Sanja Mikulovic, Stefan Remy Open Access Mocellin et al. investigate the functional role of the MSDBglu inputs to the VTA. Combining in vivo circuit manipulation and in vitro electrophysiology, they show that the MSDBglu-VTA pathway bidirectionally controls locomotion, increases environmental exploratory actions, and relies on septal inputs to VTADA, VTAglu, and VTADA/glu neurons. 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