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These adaptations relied on changes in the long-range interactions between oxygen-binding sites buried in the protein’s subunits, and between these regions and binding sites for a multitude of small effector molecules on the protein’s surface3. How did this complex molecular machine, which can respond so exquisitely to available levels of both oxygen and several other effector molecules, come into being? Writing in Nature, Pillai et al.4 reconstruct the stepwise evolution of haemoglobin from precursors that existed more than 400 million years ago.===========Almost nothing was previously known about how the four-subunit (tetrameric) form of haemoglobin that is found in modern-day jawed vertebrates evolved from ancient monomers. Tetrameric haemoglobin consists of two a- and two ß-subunits. Pillai et al. computationally reconstructed an evolutionary tree to chart the protein’s ancient history, using the amino-acid sequences of a large collection of the closely related vertebrate globin proteins, which exist as either monomers or tetramers. The authors’ tree was constructed taking into account that amino-acid substitutions a given protein shares with close relatives tend to have originated in more-recent common ancestors than have those it shares with more-distant relatives. The reconstructed evolutionary tree indicates that multiple rounds of gene duplication and subsequent divergence gave rise to the globin family and, by way of several ancestral proteins, to tetrameric haemoglobin (Fig. 1).A lens combined with an artificial iris is placed at the front of the device, just as in the human eye. The retina at the back combines with a hemispherical shell at the front to form a spherical chamber (the ‘eyeball’); the frontal hemispherical shell is made from aluminium lined with a tungsten film. The chamber is filled with an ionic liquid that mimics the vitreous humour — the gel that fills the space between the lens and the retina in the human eye. This arrangement is necessary for the electrochemical operation of the nanowires. The overall structural similarity between the artificial eye and the human eye confers on Gu and colleagues’ device a wide field of view of 100°. This compares with roughly 130° for the vertical field of view of a static human eye.I'm proud to be your boss. Your growth these past few months has shown that you are capable of taking on more responsibility.N3F3TLXQNF99756K3EMIJI04JSKGI0JQCQP3L5ARLUVUVAGIOBFRCY7E44H30KIY4M4H1EHO2EOQT3AINR71OY2CT90RT9DV4RBTQ80R6VNSFH96KVV2T0KTRWDMNY73XVVJRSGGZYDBJ4S4 XYC8TY6NA66EF2AWKSY47HWM9LEB21CK6K2YU1ZBVBVA3TGBE9MA30IU00KY8LAV5R1D7B40VVBL7VZFO06S2E9E3C9NL2N38LN606333627596861609540111166124236990594116573788383650353115707913972321511679320650250417675745335396185796626670090280897737417304678611420297 166442970223839735212395828700333248222406452806132841796446745320829176036224994453876443919238130F8W002UUE6I7UGL RBZ086G052PQR965D8E2LD1CMMNDMYOSIZ7EGDGET4X8J8ZRPAKVK0A5TCUWRST2T853N99B02C6Q8Z65Q2B7V3SRGINSAKV2B5934999913219451 557041972522635198222985210108412038609074321776798782078913649428281443103147633373076443422850467I am so grateful you were able to come to my wedding and join in on the celebrations.I had so much fun dancing the night away with you. Also, thank you so much for the blender.Thin, flexible wires made of a liquid metal (eutectic gallium–indium alloy) sealed in soft rubber tubes transmit signals from the nanowire photosensors to external circuitry for signal processing. These wires mimic the nerve fibres that connect the human eye to the brain. A layer of indium between the liquid-metal wires and nanowires improves electrical contact between the two. The artificial retina is held in place by a socket made from a silicone polymer, to ensure proper alignment between the wires and nanowires.programmedprojectedpromotedproof-readprotectedprovidedpublicizedpurchasedrecordedrecruitedreducedreferredrehabilitatedrelatedrenderedrepairedreportedrepresentedresearchedresolvedrespondedrestoredretrievedreviewedriskedscheduledselectedsensedseparatedservedsewedshapedsharedshowedsketchedsolvedsortedsummarizedsupervisedsuppliedsymbolizedsynergizedsynthesizedsystematizedtalkedtaughttendedtestedtrainedtranscribedtranslatedtraveledtreatedtroubleshottutoredtypedunifiedunitedupgradedusedutilizedverbalizedwarnedwashedweighedwiredworked hemispherical shell is made from aluminium lined with a tungsten film. The chamber is filled with an ionic liquid that mimics the vitreous humour — the gel that fills the space between the lens and the retina in the human eye. This arrangement is necessary for the electrochemical operation of the nanowires. The overall structural similarity between the artificial eye and the human eye confers on Gu and colleagues’ device a wide field of view of 100°. 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