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Learn about this prescription medicine for patients with moderate Alzheimerâs
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[Prescribing Information]( [Important Risk Information](
Dear Caregiver,
There are treatments for moderate to severe Alzheimer's disease (AD) that are currently available. Ask the healthcare provider about all available treatment options that may benefit your loved one.
Did you know:
EVERY 66 SECONDS someone in the U.S. develops Alzheimerâs disease1
According to a U.S.-based survey, nearly 50% OF AD
PATIENTS are already in the MODERATE TO SEVERE
STAGE AT THE TIME OF DIAGNOSIS2
NAMZARIC® (memantine and donepezil hydrochlorides) extended release is the FIRST AND ONLY once-a-day capsule that works on two pathways in the brain to fight the symptoms of moderate to severe AD.
NAMZARIC may:
⢠Improve cognition, also known as mental function
⢠Improve overall function
⢠Slow down the worsening of symptoms for a while
There is no evidence that NAMZARIC prevents or slows the underlying disease process in patients with AD.
Keep in mind, it takes time for any treatment to begin working. If your loved one is being treated for moderate to severe Alzheimerâs disease, symptoms may progress more slowly, remain the same for a period of time, or show some improvements for a period of time.
INDICATION AND USAGE
NAMZARIC is a prescription medicine approved to treat moderate to severe Alzheimer's disease in patients who are taking donepezil hydrochloride 10 mg.
IMPORTANT RISK INFORMATION
NAMZARIC should not be taken by anyone who: has an allergy to memantine HCl, donepezil HCl, medicines that contain piperidines, or any of the ingredients in NAMZARIC.
Please see additional Important Risk Information below.
PATHWAY 1
Acetylcholinesterase
(aâ¢ceâ¢tylâ¢choâ¢linâ¢esâ¢terâ¢ase) inhibitors (AChEIs), such as donepezil HCl, are thought to work by slowing the breakdown of a chemical in the brain called acetylcholine. This chemical is involved in learning and memory.
PATHWAY 2
Glutamate
(gluâ¢taâ¢mate) receptor blockers, such as memantine HCI, may help regulate the abnormal activity of glutamateâanother chemical in the brain that is important for learning and memory.
IMPORTANT RISK INFORMATION (continued)
Before taking NAMZARIC, tell the doctor about all of the patientâs medical conditions, including:
⢠heart problems including an irregular, slow, or fast heartbeat
⢠asthma or lung problems
⢠seizures
⢠stomach ulcers
⢠bladder, kidney, or liver problems
⢠any surgical, dental, or other medical procedures scheduled when anesthesia may be used
Tell the doctor about all the medicines the patient takes, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
What are the possible side effects of NAMZARIC?
NAMZARIC may cause serious side effects, including:
⢠muscle problems in patients given anesthesia
⢠slow heartbeat and fainting. This happens more often in people with heart problems. Call the doctor right away if the patient faints while taking NAMZARIC.
⢠more stomach acid. This raises the chance of ulcers and bleeding especially when taking NAMZARIC. The risk is higher for patients who have had ulcers, or take aspirin or other NSAIDs.
⢠nausea and vomiting
⢠difficulty passing urine
⢠seizures
⢠worsening of lung problems in people with asthma or other lung disease
The most common side effects of memantine HCl include: headache, diarrhea, and dizziness.
The most common side effects of donepezil HCl include: diarrhea, not wanting to eat (anorexia), and bruising.
These are not all the possible side effects of NAMZARIC.
Please see full [Prescribing Information]( including Patient Information.
References: 1. Alzheimer's Association. Alzheimer's disease facts and figures. Alzheimers Dement. 2016;12(4):459-509. 2. Alzheimer's Disease Physician Study ©2013 GfK Healthcare.
For more information about NAMZARIC, please visit [Namzaric.com]( or call Allergan Customer Relations and Medical Affairs toll-free at 1.800.678.1605.
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Allergan® and its design are trademarks of Allergan, Inc.
NAMZARIC® and its design are trademarks of Merz Pharma GmbH & Co. KGaA.
© 2017 Allergan. All rights reserved.
NMZ107058-b 07/17
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