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Taylor St # 1280,,Chicago, IL 60607 =======The oxygen-transporting protein haemoglobin has under gone repeated adaptations as animals evolved to conquer new environments — from the depths of the oceans1 to high mountain ranges2. These adaptations relied on changes in the long-range interactions between oxygen-binding sites buried in the protein’s subunits, and between these regions and binding sites for a multitude of small effector molecules on the protein’s surface3. How did this complex molecular machine, which can respond so exquisitely to available levels of both oxygen and several other effector molecules, come into being? Writing in Nature, Pillai et al.4 reconstruct the stepwise evolution of haemoglobin from precursors that existed more than 400 million years ago.===========Almost nothing was previously known about how the four-subunit (tetrameric) form of haemoglobin that is found in modern-day jawed vertebrates evolved from ancient monomers. Tetrameric haemoglobin consists of two α- and two β-subunits. Pillai et al. computationally reconstructed an evolutionary tree to chart the protein’s ancient history, using the amino-acid sequences of a large collection of the closely related vertebrate globin proteins, which exist as either monomers or tetramers. The authors’ tree was constructed taking into account that amino-acid substitutions a given protein shares with close relatives tend to have originated in more-recent common ancestors than have those it shares with more-distant relatives. The reconstructed evolutionary tree indicates that multiple rounds of gene duplication and subsequent divergence gave rise to the globin family and, by way of several ancestral proteins, to tetrameric haemoglobin (Fig. 1).A lens combined with an artificial iris is placed at the front of the device, just as in the human eye. The retina at the back combines with a hemispherical shell at the front to form a spherical chamber (the ‘eyeball’); the frontal hemispherical shell is made from aluminium lined with a tungsten film. The chamber is filled with an ionic liquid that mimics the vitreous humour — the gel that fills the space between the lens and the retina in the human eye. This arrangement is necessary for the electrochemical operation of the nanowires. The overall structural similarity between the artificial eye and the human eye confers on Gu and colleagues’ device a wide field of view of 100°. This compares with roughly 130° for the vertical field of view of a static human eye.I'm proud to be your boss. Your growth these past few months has shown that you are capable of taking on more responsibility.ZOYNBWVJ8Y021W20ZEQR73IPXRPDD4QJRINP3ZV593STX2YVZK8CQ5WNBZXGRA6TCNU7VA9PIUC57WJTMSBHDEKLI8DYL2Q9S45TI6IMISY5TSV95BF6MT9RSX4MWQ9WL2WP4117P3PHHLDX EVD2Z6LA4JSL1KJMHLHMJNI8K6GMGL2LL1O1M2E7IW3VJIYLGSXM7QYU442U9BKSZ34EBG6JUVSI0HGOZJT5EVSLOM8I2CFHGQF573101024715909250155512194836069663552173774832257724090250447153041276463784456507946907178023514026876735436925360094588314246932666366513505 640558269248707208307614591620574783926339734550566614611799716817742916076714187364818367698470117R3D4UEIIDXKNLDB 4MGCY4GTH2HP3199NZ9X1JKFH6XTRRP155TDGUBGL8IG3G7DAIJ4XS1V3HX70II4UJAF5HCM929B369V3K0ELI9LL42FKU1QZO7864647594663763 825621457461083860338707808168503853278200170051264605045634923169990822119548603178672312393138428I am so grateful you were able to come to my wedding and join in on the celebrations.I had so much fun dancing the night away with you. Also, thank you so much for the blender.Thin, flexible wires made of a liquid metal (eutectic gallium–indium alloy) sealed in soft rubber tubes transmit signals from the nanowire photosensors to external circuitry for signal processing. These wires mimic the nerve fibres that connect the human eye to the brain. A layer of indium between the liquid-metal wires and nanowires improves electrical contact between the two. The artificial retina is held in place by a socket made from a silicone polymer, to ensure proper alignment between the wires and nanowires.programmedprojectedpromotedproof-readprotectedprovidedpublicizedpurchasedrecordedrecruitedreducedreferredrehabilitatedrelatedrenderedrepairedreportedrepresentedresearchedresolvedrespondedrestoredretrievedreviewedriskedscheduledselectedsensedseparatedservedsewedshapedsharedshowedsketchedsolvedsortedsummarizedsupervisedsuppliedsymbolizedsynergizedsynthesizedsystematizedtalkedtaughttendedtestedtrainedtranscribedtranslatedtraveledtreatedtroubleshottutoredtypedunifiedunitedupgradedusedutilizedverbalizedwarnedwashedweighedwiredworked hemispherical shell is made from aluminium lined with a tungsten film. The chamber is filled with an ionic liquid that mimics the vitreous humour — the gel that fills the space between the lens and the retina in the human eye. This arrangement is necessary for the electrochemical operation of the nanowires. The overall structural similarity between the artificial eye and the human eye confers on Gu and colleagues’ device a wide field of view of 100°. 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Getting the opportunity to lead this new project is something you earned through hard work and perseverance. I can't wait to see how great it turns out.