Is this curcumin’s most amazing benefit yet?

Top regenerative medicine pioneer reveals how mainstream medicine got curcumin ALL WRONG [Click here](2931e/ct0_0/1/ms?sid=TV2%3AqjFEIpiix) to view this message in your browser | [Click here](2931e/g-0be0/zout?sid=TV2%3AqjFEIpiix) to stop receiving our messages [] [] Al Sears, MD 11905 Southern Blvd. Royal Palm Beach, FL 33411 [] October 27, 2022 [] Top regenerative medicine pioneer reveals how mainstream medicine got curcumin ALL WRONG! Unlock ALL 7 Natural Healing Wonders of the Curcumin Root - Promote healthy inflammatory responses1… — Clinical Nutrition - Support normal blood glucose ranges2… — Drug Research - Protect working memory and focus3… — Pharmaceuticals (Basel) - Boost everyday moods4… — Journal of Affective Disorders - Support normal cholesterol levels and weight5… — Clinical Nutrition ESPEN - Maintain vascular health6… — Current Pharmaceutical Design - Protect normal liver function7…— Complementary Therapies In a recent report published in the Journal of Medicinal Chemistry, pharma scientists claimed the buzz about curcumin was “much ado about nothing.”8 According to them, it’s “unstable” … “non-bioavailable” … and “highly improbable” as a therapeutic agent—at least from a drug discovery standpoint. Inspired by Big Pharma’s Failure You see, they weren’t looking for natural health answers. They were on the hunt for the next big prescription drug. A pill that could make billions for Big Pharma. Something they could patent, market, and take to the bank. But their approach couldn’t unlock curcumin’s true powers So they dismissed it out of hand. How did they put it? “A missile that continually blows up on the launch pad.” And with that, I had to shake my head. Talk about not seeing the forest for the trees. Curcumin has been a mainstay of Ayurvedic traditions for thousands of years, and for good reason— Its incredible effects can change your life! But leave it to Big Pharma to dismiss a natural solution when it won’t conform to their business plan. Their report is totally wrong, and… It’s time to set the record straight I’ve treated over 25,000 patients from around the world with my advanced natural therapies and have conducted extensive clinical research of my own. And I can tell you exactly where these mainstream researchers went wrong. Driven only by profit, drug makers crippled curcumin’s true potential You see, drug companies like to isolate molecules and enzymes and use them as stand-alone compounds. This is how they make their drugs unique and get their coveted patents. It’s their golden ticket to billions in profits. So they only considered a single component of the curcumin root. They isolated one phytochemical family, the curcuminoids, and then administered it virtually alone—as if it was a drug. But curcumin is not a drug. And that’s not how the curcumin root works! In that isolated form, your body struggles to absorb it. Very little of the curcuminoids make it into your bloodstream. That’s why Big Pharma thinks it’s a “failure.” And truth be told, most curcumin supplements really are a failure. They ignore how traditional medicine systems have used curcumin successfully for thousands of years. But I’ve done my research. And once I share the three secrets of curcumin bioavailability, you’ll finally… Unlock the natural wonders of the curcumin root for yourself Indeed, new science from top journals confirms how you can tap into the curcumin root’s life-giving ability to support… - Healthy inflammatory processes9 - Stable blood sugar metabolism10 - Memory and mental focus11 - Healthy moods12 - - Vascular health function13 - - Healthy liver function14 - - Normal cholesterol metabolism15 I’ll explain everything just ahead — and introduce you to… The unique time-tested formula that makes the most of it And that’s why I’m writing to you today. You see, most curcumin supplements don’t deliver on curcumin root’s promise. They squander its potential. Their formulators make the very same mistake the pharma researchers made…and then they brag about it. They advertise how their curcumin is standardized to 95% curcuminoids in the mistaken belief that they’re doing good. Fact is, herbs are routinely processed to isolate and concentrate the beneficial components. For most of them, it works. But not with curcumin. And that’s why so many people are surprised to learn… Bio-Activation Secret #1: The whole root holds the key to bioavailability Of course, ancient herbalists always used curcumin in its whole-root powder form. They didn’t have the technology to extract certain components and concentrate them, as we do today. And as it turns out, they didn’t need it. Traditional experts I’ve studied with still recommend the whole root powder for curcumin’s powerful effects. And it took an international team of researchers to confirm: They’re absolutely right! Scientists from the U.S. and India found that compared with two typical curcumin products they tested… A full-spectrum curcumin powder produced 6x greater absorption!16 The full-spectrum curcumin included all curcumin root components—and it produced the highest uptake of curcuminoids into the bloodstream. This news must shock the curcuminoids-only crowd. It shows that curcumin root includes critical co-factors that help your body digest and absorb all of its components—especially the curcuminoids. This is what will help you unleash its full health support and benefits for your joints… brain… metabolism… and more. And it shouldn’t be such a surprise: We’ve known about absorption “co-factors” for decades I’ve told patients since the 1990s how phytonutrient co-factors in whole foods and herbs help maximize digestive breakdown and bioavailability. Curcumin is one of the biggest examples. Down through the ages, the human body evolved to recognize the “whole root” as food and digest it accordingly. And as I tell my patients— Taking curcumin without these co-factors is like buying a car without wheels — it won’t get you anywhere! This result was confirmed even more spectacularly in a second study—this one at a leading New Zealand university. Scientists again tested a full-spectrum curcumin powder with its complete “food matrix” against a standardized curcumin product and freshly shredded turmeric. The full-spectrum powder produced “significantly higher amounts” of plasma curcuminoids — more than 40x greater than the typical curcumin and even 79% greater than freshly grated turmeric!17 You almost have to feel sorry for the pharma researchers testing isolated curcuminoids over and over again. They just don’t get it! And neither does the supplement industry. And here’s something else. When supplement makers concentrate curcuminoids and throw out the rest, they make another embarrassing mistake. You see, there’s a second powerful benefit to whole-root curcumin: The other root compounds read like a “who’s who” of healthy super-nutrients! Curcumin is a nutritional powerhouse, according to a recent analysis from the National Root Crops Research Institute. It contains “considerable amounts” of anthocyanins, alkaloids, flavonoids, and phenolics that “largely contribute to the antioxidant activities” of curcumin.18 Fact is, anthocyanins are among the most famous super-antioxidants of all, known for their brain, eye, and immune system benefits. They’re why blueberries are considered the world’s best “super-food!” And according to top experts, the root also contains phytosterols that support cholesterol and prostate health, as well as omega-3s and alpha-linolenic acid.19 Why would supplement makers process them out? All that nutrient power is curcumin root at its best! I say take it all! And I’m not alone. Curcumin’s amazing profile of phytonutrients piqued the interest of one research team. They asked the question: what happens when you take the curcuminoids out of curcumin? So they tested a curcumin extract that excluded the curcuminoids in a randomized placebo-controlled clinical trial for joint-health support. And it still works wonders. It worked significantly better than placebo to keep joints comfortable20 This confirmed to me how truly remarkable curcumin is. It’s not just about the curcuminoids. It’s an army of bioactive nutrients — and a formidable one! And that brings me to the next key to curcumin bioavailability: Bio-Activation Secret #2: The ancient practice that boosts absorption by 2,000%21 The use of black pepper dates back to the Charaka Samhita, one of the foundational texts from ancient India. And the use of black pepper with curcumin can be traced back just as far. The ancients knew through observation that the two worked together to bring about better results: Joints stayed comfortable longer. Declinine memory felt sharper. Energy bounced back stronger. Moods lifted higher. This nutrient team was so widely used Ayurvedic traditions that a modern-day pharmacologist decided to put it to the test. In 1998, a university team in India tested curcumin absorption rates when taken with — and without — a black pepper extract called piperine. The results were stunning: taken with piperine, curcumin bioavailability increased a remarkable 2000%. Once again, the ancients were proven right. Since then, this piperine-curcumin research has been cited by more than 400 studies around the world. It may not be on Big Pharma’s radar, but it will definitely help you experience everything the remarkable curcumin root can offer. And here’s another breakthrough drawn from the ancient teachings—one that’s not nearly as well known: Bio-Activation Secret #3 Team “synergy” is the best route to success Big Pharma and the supplement industry are both stuck on curcuminoids alone. But as I’ve explained, that approach will get you nowhere. And I’ll go one step further. Because the truth is—as we learned from piperine— Even curcumin itself doesn’t work best alone. And that’s the third secret to unlocking curcumin’s full bioactivity: it works best in a team. But not just any team. I learned this first-hand from traditional herbalists in India and on the island nation of Bali, both worlds long steeped in the health-supporting powers of curcumin. In India, Ayurvedic practitioners described how curcumin works best combined with its close relative in the Zingiberaceae plant family: the ginger root. Indeed… Since ancient times, curcumin and ginger are mentioned together in revered Indian texts22 It explains why this team is used so often and for so many reasons in Ayurvedic traditions. Modern science tells us ginger is rich in phenolic compounds called gingerols noted for their support of healthy inflammatory processes in the body.23 And even mainstream institutions like the famous Cleveland Clinic agree: Ginger works like curcumin to help you maintain comfortable joints…support healthy blood sugar and cholesterol… and promote normal digestive processes.24 And yet again, the ancients were right: the natural synergy between the two is real! Next is another pungent Zingiberaceae root famous in Bali’s herbal traditions: The rainforest secret to a comfortable body My journey to Bali took me deep into the interior to the foot of Bali’s volcano, far away from the beaches where most tourists flock. There I met Lelir, a sixth-generation healer, and her husband Westi, a fourth generation farmer who cultivates Bali’s famous herbs using traditional methods. Between them, they may know more about cultivating, preparing, and using Bali’s healing herbs than anyone else on Earth. So when my new friends introduced me to galangal root, I knew I was on the right track to the curcumin support I was seeking. As it turns out, this little-known relative of curcumin and ginger has greater nutrient power than both of these nutrient root superstars!25 Galangal root is packed to the brim with free radical-scrubbing polyphenols that support healthy inflammatory processes in joints, muscles, and organs—everywhere in the body. And there you have it—the three secrets that help you make the most of the curcumin root. Simple, right? Big Pharma missed the boat, but you won’t. With whole-root powder…black pepper extract…and a constellation of synergistic nutrients that bring out its best… …you can unleash the full powers of the curcumin root inside your body. But here’s where I’m left shaking my head. These three bio-activation secrets are so natural…time-tested…and easy, too: You’d think that supplement makers would be leading the charge. But they’re not! Good luck finding any curcumin supplement that embraces everything I’ve just shared with you. Everywhere I looked, I found the same mistakes that led pharma researchers down the wrong path. So I took matters into my own hands. With my team of formulators, I brought together… 1.A “full matrix” curcumin root powder packed with essential co-factors and co-nutrients… 2. The absorption-boosting wonder of piperine black pepper extract… 3. The synergy of three “super roots” from the incredible life-giving Zingiberaceae family… …and combined them based on the levels and balance recommended to me by traditional Ayurvedic and Balinese healers. You’ll find this formidable force of nature in a one-of-a-kind formula: Curcumin Triple Burn from Primal Force Each daily serving of Curcumin Triple Burn delivers a full 1,000 mg of the finest quality whole curcumin (turmeric) root powder I could find. It’s nestled with premium-grade ginger root (100 mg), galangal root (100 mg), and BioPerine® piperine (5 mg). I call it the world’s first triple-activated curcumin. And mark my words: with Curcumin Triple Burn… …the wheels are on... …the fuel tank is filled… …the engine is primed… …And the amazing power of curcumin is at your command. And wait until I tell you what else we just discovered about curcumin… Remarkably, new research reveals what may actually be curcumin’s most powerful mechanism of action in the body. Big Pharma’s scientists didn’t explore it. They never gave it more than a passing thought. They focused on blood levels of curcuminoids as the measure of bioactivity. But we now know that’s just part of the overall picture. New studies show… Curcumin remains in high concentrations in your gut26 Why does that matter? Because that’s the very core of your body’s microbiome—the vast universe of living microbes in your body that affect so many aspects of health. And according to scientists at a major European university, the two-way interplay between curcumin and gut microbiota is stunning. In a 2021 study,27 they explain how gut microbes activate curcumin by transforming it into curcumin metabolites… …and these highly bioactive metabolites support a wide range of normal antioxidant, anti-inflammatory, and neuro-protective processes in the body.28 Curcumin, in turn, works wonders for your microbiome by: - Promoting beneficial bacterial strains - Supporting healthy intestinal barrier function - Sustaining microbial biodiversity and composition - Easing gut concerns with end-to-end digestive support Big-time support for a stronger microbiome? Count me in. As we now know... Our microbiome is the gateway to vibrant health! It plays a major role in immune health29 It also supports healthy cognition and moods, thanks to what scientists call the “gut-brain axis.”30 It impacts your enteric nervous system (ENS)—the network of neurons in your gut that control all aspects of digestion and gastrointestinal health.31 And a new study from a top Dutch university shows how a healthy microbiome even supports vascular health and arterial function!32 That just scratches the surface. The human microbiome is among the hottest areas of health research today. And that, by the way, is another reason I recommend the whole-root curcumin you get in Curcumin Triple Burn: It’s a curcumin your microbiome recognizes… …one with all the co-factors and co-nutrients that do your body good! The curcumin-microbiome interaction helps explains curcumin’s unique ability to promote great health all over.33 It offers new clues about the action of curcumin root, which has earned so much respect through the ages. Imagine explaining all this to ancient healers who passed down the secrets of the curcumin root from generation to generation. They knew it was special. They saw how it was safe, gentle, and effective — and never hesitated to recommend it as part of one’s daily diet. Today, of course, we have the advantage of clinical testing to see what works and what doesn’t. And the more research I review, the more my admiration for curcumin grows because… I see many of today’s biggest age-related worries getting cut down to size! The latest gold-standard research shows how curcumin can help ease … …Your Joint-Health Worries… In a double-blind, placebo-controlled trial, the curcumin group was given 1,000 mg curcumin with piperine daily for eight weeks. Scientists found a significant reduction in C-reactive protein (CRP), a well-known joint-health risk factor, among the curcumin group.34 …Your Blood Sugar Worries… In a three-month clinical trial, 50 adults were given 500 mg daily of curcumin with piperine and 50 patients received a placebo. The results left no one doubting curcumin’s ability to help sustain healthy glucose levels within the normal range!35 …Your Memory Worries… A 2021 meta-analysis of 8 randomized controlled trials (RCTs) determined that curcumin intake supported healthy working memory significantly better than placebo—and helped support healthy brain cells, too.36 …Your Cholesterol Worries… In a 2020 study of curcumin’s effects on lipids and glycemic control, 60 women were given either 500 mg of curcumin daily or placebo for 12 weeks. Before-and-after testing revealed curcumin’s superior support for both cholesterol and glucose levels.37 …Your Circulation Worries … A 2019 meta-analysis of 11 randomized controlled trials concluded that curcumin supplementation helped maintain vascular endothelial function and healthy blood flow.38 What’s more, double-blind, placebo-controlled studies also show curcumin’s ability to… …Help Keep You On an Even Keel … Fifty-six participants took either 1000 mg of curcumin daily or placebo in an eight-week Australian study. The result? Better daily moods for the curcumin group, according the report published in a leading health journal.39 … Support Your Healthy Liver Function… According to a 2019 clinical trial, curcumin outperformed placebo in supporting your body’s main detoxification organ—and this was a study where half the participants took 500 mg of curcumin with 5 mg piperine daily for 12 weeks.40 Frankly, I’m amazed me that so many “experts” still get curcumin wrong. Evidence shows when handled the right way… It produces a cascade of results from head to toe! That’s why I made sure each daily serving of Curcumin Triple Burn includes a full 1,000 mg of whole-root curcumin powder supported by a powerful co-nutrient team. I can think of no better nutritional solution to support your overall health…at any age. And Curcumin Triple Burn has one more trick up its sleeve—one I’ve truly grown to appreciate myself over the years… It’s called “the elixir of life” for its rejuvenating effects In India, it’s used to support mental focus and memory.41 In Bali, it’s used to promote a stronger immune system.42 Around the world, it’s used to maintain emotional balance and stand strong against stress.43 It’s called Holy Basil. And with all its qualities, it’s no surprise that this amazing plant is the most studied herb on the entire Indian subcontinent.44 It’s rich in powerful antioxidants like rosmarinic acid and ursolic acid as well as anti-stress compounds called ocimumosides.45 I call it the “feel your best” herb—and as I see it… What better to add to a formula that already does so much to promote your well-being So if you want genuine support to help maintain… …Comfortable joints… …Great moods and sharp memory… …Healthy blood sugar and cholesterol… Those goals are closer than you think with Curcumin Triple Burn. And I’ll be completely honest with you. Too many people have been let down by poorly formulated curcumin. Perhaps you’ve tried curcumin that “failed to launch” because the formulator didn’t understand the unique nature of curcumin bioavailability. If so, I hope you try again because… Curcumin Triple Burn is in a class by itself As both a doctor and as an expert in traditional systems, I’m doing my best to bring you the truth about curcumin root. Where others have failed, Curcumin Triple Burn will succeed. Its three secrets of bioavailability and the triple-root synergy packed into every capsule ensure you will enjoy the results I’ve described in this letter. I’m convinced you’ll feel the difference with Curcumin Triple Burn beginning within a few short weeks, and I stand behind it 100%. But results speak louder than words… …so the next step is up to you. When the day comes when you feel as if you turned back the clock by years and can… …Walk, stretch, bend, get up and reach with so much comfort and ease… …Feel mental clarity and focus all day as you go about your business… …Enjoy calmness and upbeat emotions even on stressful days… …Experience digestive comfort day in and day out… …Feel “fresh within” with energy surging through your body… You’ll know you discovered the “right” curcumin Not the ineffective limited-spectrum form tested by Big Pharma and sold in most dietary supplements… …But the full-spectrum whole-root curcumin surrounded by a team of synergistic ingredients that bring out its best. I’d love to put Curcumin Triple Burn in your hands for your own clinical test. And I’ll meet you in the middle. For right now…in this small window of time…you can get your supply for as little as $29.95 per bottle…and get free shipping too. The special price in this offer will never be lower. And with our BEST OFFER, your price will never go up for as long as you take Curcumin Triple Burn. It’s an annual savings of over $263.00! On top of that, I take all the risk myself. My 90-Day Money-Back Guarantee states that either your 100% satisfied or I’ll send your money back. Nothing can go wrong — there’s nothing to lose! Here’s how easy it is. Order Curcumin Triple Burn today at a special price that won’t last long, and use as directed. By the time you finish your first bottle, you’ll feel the results coursing through your body and mind. That’s my promise to you. But if you’re not 100% satisfied for any reason, then simply let me know. Contact us within 90 days and we’ll refund you the purchase price right away. No hassle whatsoever. Believe me, I’m not worried about that. The fact that you’ve read this far… Tells me you’re committed to building a healthier, happier life for yourself …and that’s all I need to know. Here at the Sears Institute for Anti-Aging Medicine, it’s my mission to help people like you live your best life. One filled with health and vitality. And I’m a firm believer in the saying “success breeds success.” So that’s why I’ll also send you, absolutely free, two Special e-Reports filled with even more ways to lift your health to new heights. The first is developed from an incredible Nobel Prize-winning discovery: AGELESS MIND: The 21 Secrets to Restore, Revive and Strengthen Your Brain Now for the first time in history, we can restore the brain’s youthful vigor and avoid the painful and debilitating loss of cognitive function. And in this breakthrough guide, you’ll discover how. You’ll learn about the three real culprits behind cognitive loss and memory problems—and how to neutralize them with solutions that include: √ The #1 nutrient for growing limitless new brain cells and new neural networks that ramp up your brainpower at any age √ The little-known supplement that restores Nerve Growth Factor (NGF)—a powerful protein that controls the growth and maintenance of your brain’s neurons √ The top 6 sources of “brain fuel” your doctor never told you about—six of the most effective brain boosters available! √ And much more The price of Ageless Mind is normally $39.95 if bought alone, but it’s yours absolutely FREE. And your second free e-Report is: The 7 Pillars of a Long and Healthy Life Imagine living a long, full life without giving up one ounce of youthful vitality…a life of purpose, characterized by wisdom and longevity. If that sounds like a plan, then The 7 Pillars are for you. This step-by-step guide shows you how to take control of your own aging process, with guidelines that include: - Why you should rediscover the foods you really love—and enjoy them without guilt - The 11 physical and chemical biomarkers that reveal specifically what you need to do to enhance your vitality and slow the aging process - The age-slowing super-nutrients that really work to protect your body from oxidative stress and the stresses of life - How to activate your anti-aging gene and slow down aging by a factor of three while reducing your risk of deadly age-related problems - And much more You’d have to pay $39.95 if you bought The 7 Pillars by itself. But I’m giving it to you free of charge once you order Curcumin Triple Burn. Already you’re looking at savings of up to $263.00 and FREE e-Reports worth $79.90 by ordering today. The e-Reports are yours to keep no matter what you decide to do. As you may have guessed by now, I take Curcumin Triple Burn daily myself. I consider it an “essential” formula. But the choice, of course, is yours to make You could choose to do nothing at all. You can continue worrying about your joints…your memory and your moods… your blood sugar and cholesterol—and simply do your best to “put up” with these issues even as they grow worse. Or you could try other curcumin products. But if you do, please remember everything I’ve said about curcumin here. I don’t want you to waste money on a curcumin product your body will struggle to absorb. And in my experience, that’s the vast majority of them. Or you can try Curcumin Triple Burn without risk. Use it for a full month. Take just two capsules daily—with meals that contain dietary fats for optimal absorption. That will help you experience more results much faster. I’m convinced its full, bio-activated 1000 mg dosage will deliver what you expect—and what you hope for—and outperform even the most expensive curcumin formulations on the market today. Before long, you’ll appreciate all the research and care that went into its formulation. But most of all, you’ll appreciate how it makes you feel, because … This triple-activated curcumin will lead to a stronger, better, and happier you So please take this moment to place your order. Choose the option that best fits your needs. Then download your two Bonus e-Reports worth $79.90 and begin your own transformation. You have nothing to lose by trying Curcumin Triple Burn. There’s no risk. Not with my 90-day money-back guaranteed. Even if you use an entire bottle and send it back…I’ll still process your full refund, no questions asked. But when it works, as it will, you’ll want to order more Curcumin Triple Burn…and you won’t ever settle for anything less. Order today. You’ll be glad you did! Choose your order below NOW BEST DEAL: Become a Curcumin Triple Burn VIP! Huge VIP Savings, Plus FREE Shipping for LIFE Save 30% by joining the Curcumin Triple Burn 3-month VIP Auto Delivery Program, which includes a locked-in discount and FREE Shipping for Life. You’ll get [3 bottles of Curcumin Triple Burn](2931e/ct1_0/1/lu?sid=TV2%3AqjFEIpiix) shipped right to your door every 3 months for just $29.95 per bottle. And you will get this discounted price along with FREE shipping for as long as you take Curcumin Triple Burn. That’s an annual savings of over $263 — and this price will never go up! You’ll never have to worry about reordering and you can cancel anytime. For your convenience, your credit card will be automatically charged $89.85 with each shipment. You can cancel at least one day before my next shipment to avoid being billed for the next shipment by calling 1-866-895-8555. 2931e/ct1_1/1/lu?sid=TV2%3AqjFEIpiix GREAT VALUE: You’ll get [3 bottles](2931e/ct2_0/1/lu?sid=TV2%3AqjFEIpiix) of Curcumin Triple Burn shipped right to my door for only $38.65 each plus shipping and handling. Your credit card will be charged a one-time payment of $115.95 plus shipping. That’s a saving of 10%! 2931e/ct2_1/1/lu?sid=TV2%3AqjFEIpiix TRIAL OFFER: I’ll get 1 bottle of Curcumin Triple Burn for a one-time payment of $42.95 plus shipping and handling. [ORDER OUR TRIAL OFFER](2931e/ct3_0/1/lu?sid=TV2%3AqjFEIpiix) [Guarantee] --------------------------------------------------------------- REFERENCES 1. Panahi Y, Hosseini MS, Khalili N, Naimi E, Majeed M, Sahebkar A. Antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome: A randomized controlled trial and an updated meta-analysis. Clinical Nutrition. 2015;34(6):1101-1108. doi:10.1016/j.clnu.2014.12.019 2. Panahi Y, Khalili N, Sahebi E, et al. Effects of Curcuminoids Plus Piperine on Glycemic, Hepatic and Inflammatory Biomarkers in Patients with Type 2 Diabetes Mellitus: A Randomized Double-Blind Placebo-Controlled Trial. Drug Research. 2018;68(07):403-409. doi:10.1055/s-0044-101752 3. Tsai I-C, Hsu C-W, Chang C-H, Tseng P-T, Chang K-V. The Effect of Curcumin Differs on Individual Cognitive Domains across Different Patient Populations: A Systematic Review and Meta-Analysis. Pharmaceuticals. 2021;14(12). doi:10.3390/ph14121235 4. Lopresti AL, Maes M, Maker GL, Hood SD, Drummond PD. Curcumin for the treatment of major depression: A randomised, double-blind, placebo controlled study. Journal of Affective Disorders. 2014;167:368-375. doi:10.1016/j.jad.2014.06.001 5. Karimian MS, Pirro M, Johnston TP, Majeed M, Sahebkar A. Curcumin and Endothelial Function: Evidence and Mechanisms of Protective Effects. Current Pharmaceutical Design. 2017;23(17). doi:10.2174/1381612823666170222122822 6. Saberi-Karimian M, Keshvari M, Ghayour-Mobarhan M, et al. Effects of curcuminoids on inflammatory status in patients with non-alcoholic fatty liver disease: A randomized controlled trial. Complementary Therapies in Medicine. 2020;49:102322. doi:10.1016/j.ctim.2020.102322 7. Jamilian M, Foroozanfard F, Kavossian E, et al. Effects of curcumin on body weight, glycemic control and serum lipids in women with polycystic ovary syndrome: A randomized, double-blind, placebo-controlled trial. Clinical nutrition ESPEN. 2020;36:128-133. doi:10.1016/j.clnesp.2020.01.005 8. Karimian MS, Pirro M, Johnston TP, Majeed M, Sahebkar A. Curcumin and Endothelial Function: Evidence and Mechanisms of Protective Effects. Current Pharmaceutical Design. 2017;23(17). doi:10.2174/1381612823666170222122822 9.Saberi-Karimian M, Keshvari M, Ghayour-Mobarhan M, et al. Effects of curcuminoids on inflammatory status in patients with non-alcoholic fatty liver disease: A randomized controlled trial. Complementary Therapies in Medicine. 2020;49:102322. doi:10.1016/j.ctim.2020.102322 10. Nelson KM, Dahlin JL, Bisson J, Graham J, Pauli GF, Walters MA. The Essential Medicinal Chemistry of Curcumin. Journal of medicinal chemistry. 2017;60(5):1620-1637. doi:10.1021/acs.jmedchem.6b00975 11. Panahi Y, Hosseini MS, Khalili N, Naimi E, Majeed M, Sahebkar A. Antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome: A randomized controlled trial and an updated meta-analysis. Clinical Nutrition. 2015;34(6):1101-1108. doi:10.1016/j.clnu.2014.12.019 12. Panahi Y, Khalili N, Sahebi E, et al. Effects of Curcuminoids Plus Piperine on Glycemic, Hepatic and Inflammatory Biomarkers in Patients with Type 2 Diabetes Mellitus: A Randomized Double-Blind Placebo-Controlled Trial. 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